Browsing by Title
Now showing items 2292-2311 of 10605
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Dehiscence and embolization of CorMatrix tricuspid valve replacement in the setting of infective endocarditis: a case report
(2018-01-31)Background: Due to increased morbidity and mortality, prosthetic valve infective endocarditis (IE) with dehiscence requires urgent intervention. Early identification and therapy may prevent embolization. Case summary: A ... -
DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis
(East Carolina University, 2010-04-15)Public concerns on phthalates distributions in the environment have been increasing since they can cause liver cancer, structural abnormalities and reduce sperm counts in male reproductive system. However, few data are ... -
Delayed Self-Fertilization in Triodanis perfoliata
(2014)Self-fertilization is a reproductive technique that allows a plant to produce offspring even when pollinators may be scarce. Utilizing the process of delayed selfing, a species is with the benefits of both cross-pollination ... -
Deletion of BmoR affects the expression of genes related to thiol/disulfide balance in Bacteroides fragilis
(2018-09-26)Bacteroides fragilis, an opportunistic pathogen and commensal bacterium in the gut, is one the most aerotolerant species among strict anaerobes. However, the mechanisms that control gene regulation in response to oxidative ... -
Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ... -
Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice
(2015)Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
(2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
(East Carolina University, 2008-04-25)In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ... -
Delination of Coastal Shark Habitat within North Carolina Waters Using Acoustic Telemetry, Fisher-Independent Surveys, and Local Ecological Knowledge
(East Carolina University, 2016-07-20)Knowledge of shark habitat preferences and use patterns is important to effectively manage shark fisheries and account for interactions between sharks and species targeted by other fishery management or conservation efforts. ... -
DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ... -
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ... -
Delineating Wastewater Contaminant Plumes from On-Site Wastewater Treatment Systems in the North Carolina Coastal Plain using Electromagnetic Induction
(East Carolina University, 2016-08-18)In North Carolina, wastewater-derived nutrients and harmful bacteria threaten public health and reduce water quality for many surface water bodies. North Carolina uses ~ 2 million on-site wastewater treatment systems, yet ... -
Delineation and mapping of coastal shark habitat within a shallow lagoonal estuary
(2018-04-12)Estuaries function as important nursery and foraging habitats for many coastal species, including highly migratory sharks. Pamlico Sound, North Carolina, is one of the largest estuaries in the continental United States and ... -
The delta-14 Mutation of Human Cardiac Troponin T Enhances ATPase Activity and Alters the Cooperative Binding of S1-ADP to Regulated Actin
(East Carolina University, 2004-12-07)The complex of tropomyosin and troponin binds to actin and inhibits activation of myosin ATPase activity and force production of striated muscles at low free Ca2+ concentrations. Ca2+ stimulates ATP activity, and at ... -
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
(East Carolina University, 2008-01-11)delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ... -
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
(East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ...