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Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
(2013)Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood ... -
Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8
(2013-10)Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein ... -
Acquiring Articles through Unmediated, User-Initiated Pay-Per-View Transactions: An Assessment of Current Practices
(East Carolina University, 2009-12)Depressed economic times often lead libraries to consider new practices, including alternatives to the traditional subscription model. This column discusses a pay-per-view (PPV) model for acquiring journal articles whereby ... -
The Acquisition of a Plastid by Haptophytes, Cryptophytes, and Photosynthetic Heterokonts
(East Carolina University, 2014)Red algae and green plants are known to have obtained their photosynthetic organelles, or plastids, through the endosymbiotic adoption of cyanobacteria. It is still widely debated as to how other eukaryotic alga such as ... -
Acquisition of Financial Education Among College Students: How Attitudes and Future Expectations Shape Desire for Personal Finance Educatio
(East Carolina University, 2018-05-24)This study used a sample of undergraduate students at a public university to determine students’ interest in and views of personal finance. Students who were surveyed responded that personal finance topics are important, ... -
THE ACQUISITION OF NEW STUDENT AFFAIRS PROFESSIONALS' BELIEFS AND PERCEPTIONS ABOUT FACULTY
(East Carolina University, 2013)The purpose of this study is to better understand how new student affairs professionals acquire their beliefs and perceptions about faculty. This study originates from a conceptual framework that includes: (1) a call for ... -
The Actin Binding Protein, Fesselin, is a Member of the Synaptopodin Family
(East Carolina University, 2008-07)Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and α-actinin. Fesselin ... -
ACTING "WHITE": THE UNSPOKEN, UNDERSTOOD HIERARCHY OF BLACKNESS
(East Carolina University, 2020-01-09)This thesis will examine how a variety of extenuating factors serve to complicate a black person's self-identity, as well as determine acceptance or exclusion from the black community in the United States. The introductory ... -
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
(2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
Activation of GPR4 by acidosis inhibits tumor cell migration, invasion and metastasis.
(East Carolina University, 2011)Melanoma and Prostate Cancer are two of the most diagnosed forms of cancer in the United States. The ability to metastasize and colonize in a distant location is one of the most devastating hallmarks of cancer as modes ...