Browsing by Author "Dohm, G. Lynis"
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Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans
Hortobágyi, Tibor; Dempsey, G. Lynis; Fraser, D. D.; Zheng, D.; Hamilton, G.; Lambert, J.; Dohm, G. Lynis (East Carolina University, 2000-01)1. Changes in muscle strength, vastus lateralis fibre characteristics and myosin heavychain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
Bikman, Benjamin Thomas (East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Regulation of GLUT4 expression in denervated skeletal muscle
Jensen, Ellis B.; Zheng, Donghai; Russell, Robert A.; Bassel-Duby, Rhonda; Williams, R. Sanders; Olsen, Ann Louise; Dohm, G. Lynis (East Carolina University, 2009-03)Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known about the signaling events that cause this decrease. Experiments were designed to test the ... -
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor.
Burguera, Bartolome; Elton, Charles W.; Tapscott, Edward B.; Pories, Walter J.; Dimarchi, Richard; Sakano, Katsu-ichi; Dohm, G. Lynis (East Carolina University, 1994-06-15)Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated, especially in skeletal ... -
Transcriptional regulation of muscle fatty acid-binding protein.
Carey, Julie O.; Neufer, P. Darrell; Farrar, Roger P.; Veerkamp, Jacques H.; Dohm, G. Lynis (East Carolina University, 1994-03-15)Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates ... -
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.
Pories, Walter J.; Swanson, Melvin S.; MacDonald, Kenneth G. Jr.; Long, Stuart B.; Morris, Patricia G.; Brown, Brenda M.; Barakat, Hisham A.; deRamon, Richard A.; Israel, R. Gay; Dolezal, Jeanette M.; Dohm, G. Lynis (East Carolina University, 1995-09)OBJECTIVE: This report documents that the gastric bypass operation provides long-term control for obesity and diabetes. SUMMARY BACKGROUND DATA: Obesity and diabetes, both notoriously resistant to medical therapy, continue ...