Browsing by Author "Ishiguro, Naoki"
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Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Osteosarcoma Cell Lines MG-63 and LM-8 in Vitro and in Vivo via Perturbation of Hyaluronan-Rich Pericellular Matrix of the Cells
Hosono, Kozo; Nishida, Yoshihiro; Knudson, Warren; Knudson, Cheryl B.; Naruse, Takahiro; Suzuki, Yoshitaka; Ishiguro, Naoki (East Carolina University, 2007-07)Numerous studies have demonstrated a correlation between hyaluronan expression and the malignant properties of various kinds of cancer , and inhibition of hyaluronan production causes decreased tumor growth. Hyaluronan ... -
Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading
Sobue, Yasumori; Takahashi, Nobunori; Ohashi, Yoshifumi; Suzuki, Mochihito; Nishiume, Tsuyoshi; Kobayakawa, Tomonori; Terabe, Kenya; Knudson, Warren; Knudson, Cheryl; Ishiguro, Naoki; Kojima, Toshihisa (2019-10-17)CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. We hypothesized that mechanical stress-induced enhancement of CD44-intracellular domain (CD44-ICD) production plays an important role in the ... -
SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES
HAMADA, TAKASHI; SAKAI, TADAHIRO; HIRAIWA, HIDEKI; NAKASHIMA, MOTOSHIGE; Ono, Yohei; MITSUYAMA, HIROHITO; Ishiguro, Naoki (2013-02)