Browsing by Author "Justus, Calvin R."
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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, Calvin R.; Dong, Lixue; Yang, Li V (2013-12-05)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, Calvin R.; Dong, Lixue; Yang, Li V. (2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Justus, Calvin R.; Sanderlin, Edward J.; Dong, Lixue; Sun, Tianai; Chi, Jen-Tsan; Lertpiriyapong, Kvin; Yang, Li V. (2017-12)Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ... -
Emerging roles for the pH-sensing G protein-coupled receptors in response to acidotic stress
Sanderlin, Edward J; Justus, Calvin R.; Krewson, Elizabeth A.; Yang, Li V. (2015)Protons (hydrogen ions) are the simplest form of ions universally produced by cellular metabolism including aerobic respiration and glycolysis. Export of protons out of cells by a number of acid transporters is essential ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Justus, Calvin R.; Sanderlin, Edward J.; Yang, Li V. (2015-05)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ...