Browsing by Author "Nyce, Jonathan W."
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Attenuated viruses and method of making the same
Nyce, Jonathan W. (1996-04-18)Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites ... -
Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents
Nyce, Jonathan W. (2000-07-13)Composition and formulations comprising a first agent such as folinic acid, pharmaceutically acceptable salts thereof or mixtures thereof, and a second agent(s) such as analgesics, muscle relaxants, mood disorder agents, ... -
Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
Nyce, Jonathan W. (2004-11-30)A pharmaceutical composition effective for preventing and alleviating bronchoconstriction, lung allergy(ies) and inflammation comprises a surfactant and an oligonucleotide anti-sense to an adenosine receptor gene, flanking ... -
Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease
Nyce, Jonathan W. (2002-10-31)A composition comprises as the active agent a Non-glucocorticoid steroid, analogue thereof, a ubiquinone, or their salts, in an amount effective for reducing levels of, or hypersensitivity to, adenosine, increasing levels ... -
Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.
Nyce, Jonathan W.; Leonard, Sherry Ann; Canupp, Dawn; Schulz, Stefan; Wong, So (East Carolina University, 1993-04-01)In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'- deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine ... -
Low adenosine agent, composition, kit and method for treatment of airway disease
Nyce, Jonathan W.; Metzger, James (1999-11-30)An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such ... -
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
Nyce, Jonathan W. (2000-02-24)A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, ... -
Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion
Nyce, Jonathan W. (2000-10-26)An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA comprises the topical admistration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide that is ... -
Method of treating adenosine depletion
Nyce, Jonathan W. (1997-08-26)A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective ... -
Multiple target hybridizing nucleic acids, their preparation, compositions, formulation, kits and applications
Nyce, Jonathan W. (1999-03-25)Antisense oligonucleotides which bind to two or more RNA targets are disclosed. -
Neuropeptide Y analogues, compositions and methods of lowering blood pressure
Nyce, Jonathan W.; Leonard, Sherry Ann (2000-06-13)Neuropeptide Y analogues, and their compositions are effective for lower blood pressure. -
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
Nyce, Jonathan W. (2000-03-21)A DNA comprises an oligonucleotide antisense to mRNA encoding an adenosine A.sub.1 or A.sub.3 receptor. The oligo is provided as a composition, various formulations, a capsule, and cartridge and in the form of a kit. The ...