Browsing by Subject "Caenorhabditis elegans"
Now showing items 1-20 of 26
-
Assessing cellular and genomic damage from environmental nickel using a GFP containing strain of Caenorhabditis elegans
(East Carolina University, 2013)Nickel is a naturally found mineral that has become widely used for many electronic devices. As use and subsequent discarding of nickel containing products continues exposure to nickel increases. Nickel can cause external ... -
Comparison of ZnO nanoparticles and ZnCl₂ induced germ cell apoptosis in Caenorhabditis elegans
(East Carolina University, 2014)There is inadequate research data available on manufactured ZnO nanoparticles. Manufactured nanoparticles are widely used in various products and production of manufactured nanoparticles is becoming increasingly abundant. ... -
Effects of Nicotine on Caenorhabditis elegans survival, reproduction, and gene expressions : Development of an Invertebrate Animal Model for Drugs of Abuse
(East Carolina University, 2011)Although much is known about the addictive effects of nicotine, the molecular mechanisms of nicotine-induced effects remain largely unclear. Specifically, little is known about the effects of nicotine on gene expression, ... -
EFFECTS OF SODIUM BENOZATE ON FAT DEPOSITION AND GROWTH IN CAENORHABDITIS ELEGANS
(East Carolina University, 2019-07-11)Clinical observation has proposed the linkage between the occurrence of obesity and slow weight loss with daily exposure to common food additives such as sodium benzoate. However, well-controlled laboratory experiments on ... -
Effects of Zinc Oxide Nanoparticles on the Pharyngeal Pumping and Neurological Behavior of C. elegans
(East Carolina University, 2018-08-02)Cogent data regarding the effects of manufactured zinc oxide nanoparticles (ZnO-NPs) on human health and other organisms is limited. With the prominence of manufactured ZnO - NPs increasing rapidly in recent years, the ... -
The Evolution of Organ Shape : Distal Tip Cell Migration and Gonadogenesis in Nematodes
(East Carolina University, 2013)Animals display a variety of shapes in nature. The different shape of homologous organs allows them to adopt different functions and therefore, allows animals to live in different ecological niches. However, little is ... -
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ... -
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
(East Carolina University, 2013)The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ... -
Genetic control of cell fate specification in Caenorhabditis elegans germline.
(East Carolina University, 2015)The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development ... -
Impacts of environmentally relevant levels of the perfluorooctanoic acid (PFOA) replacement compound GenX (Hexafluoropropylene Oxide Dimer Acid) on feeding behavior, mitochondrial ROS, and gene expression in Caenorhabditis elegans
(East Carolina University, 2023-08-03)Per- and polyfluoroalkyl substances (PFAS) are commercially manufactured chemicals known for widespread usage in different industries. Past research indicating negative health impacts and bioaccumulation in humans and the ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ... -
Nickel as a mutagen and as an enabler of EMS genotoxicity in Caenorhabditis elegans
(East Carolina University, 2016-01-15)Nickel is found naturally and vital for survival of some organisms. Nickel occurs as a metal as insoluble compounds and soluble compounds. Nickel exposure has increased due to urbanization from various sources including ... -
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
(2015-05)Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
(East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
PUF-8 and MPK-1: Genetic and Chemical Control of Spermatocyte Dedifferentiation in Caenorhabditis elegans
(East Carolina University, 2021-05-03)Stem cells face a number of major fate decision during their development: the decision to self-renew or differentiate, and then whether to remain differentiated or dedifferentiate, as occurs in some oncogenesis. A regulatory ... -
Reproductive Toxicity of Crude oil-Dispersant Mixture in Caenorhabditis elegans
(East Carolina University, 2016-05-05)As crude oil remains a vital natural resource for the energy need of the world, environmental crude oil spills continue to be a health risk to human beings and ecological systems. During clean-up efforts, surfactant-like ... -
Reproductive Toxicity of Diazinon on Caenorhabditis elegans
(East Carolina University, 2017-07-17)Worldwide, pesticide usage is on the rise. From 2006-2007, the global market saw a 1% increase in overall pesticide usage (Environmental Protection Agency 2012), a small percentage until you consider that one percent ... -
Sub-lethal toxic effect of Bisphenol A on Caenorhabditis elegans : the role of stress resistance genes in BPA-induced growth inhibition
(East Carolina University, 2014)Endocrine disrupting chemicals (EDCs) have become of concern for a variety of health issues. Bisphenol-A (BPA) is a widely studied EDC and has been characterized by its estrogen-like effects. BPA is a prevalent component ...