Browsing by Subject "AMPK"
Now showing items 1-9 of 9
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Advances in Targeting Signal Transduction Pathways
(2012-12)Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those ... -
AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
(East Carolina University, 2017-06-02)Skeletal muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and ... -
AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
(East Carolina University, 2009-05-01)One characteristic of aging skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK)occurs in response to an increased AMP/ATP ratio,which is one potential result of ... -
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
(East Carolina UniversityEast Carolina University, 2008-12-15)5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ... -
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ... -
Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
(East Carolina University, 2016-07-25)The prevalence of obesity is exponentially increasing worldwide. Although strategies such as exercise, nutritional intervention, and pharmaceutical therapies including resveratrol have been extensively studied in lean or ... -
ENHANCED INSULIN SIGNALING FOLLOWING CONTRACTILE ACTIVITY IS BLUNTED IN MYOTUBES FROM SEVERELY OBESE INDIVIDUALS WITH OR WITHOUT TYPE 2 DIABETES
(East Carolina University, 2018-06-11)Introduction: Regular exercise has been known to improve insulin sensitivity in obese/ Type 2 Diabetic (T2D) individuals. However, some obese and T2D individuals do not respond well to regular exercise in their metabolic ... -
Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase
(2012-10)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...