Browsing by Subject "Chemistry"
Now showing items 1-20 of 30
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Assessing Methodological Contamination in Organic Residue Analysis using FT-IR Spectroscopy
(East Carolina University, 2012)Organic residue analysis (ORA) has become a mainstay in modern archaeological and conservation research. Organic residues recovered from archaeological and conservation contexts represent an accumulation of materials by ... -
Benzoate: The Quantitation of Soft Drinks Implicated in Obesity
(East Carolina University, 2019-04-26)Research has shown that childhood obesity is a leading cause of diseases such as coronary artery disease, hypertension, type 2 diabetes, cancer, osteoarthritis, and many more. With approximately 17 percent of the United ... -
A Calorimetric and Spectroscopic Study of the Interactions Between Model Lipid Membrane Bilayers and Simple Sugars
(East Carolina University, 2015)It is well known that various organisms, such as the tardigrade, naturally use carbohydrates, particularly disaccharides, to help preserve their cell structural and functional integrity during freezing or dehydration. There ... -
Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
(East Carolina University, 2012)Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ... -
Determining the Chemical Structure of Brucebactin: The Sole Complex Siderophore Utilized by the Pathogenic Bacterium Brucella Abortus
(East Carolina University, 1/13/16)Brucellosis is a zoonotic bacterial disease that affects many around the world. There are over half a million new cases each year and prevalence rates in some areas of the world exceed 10 new cases per 100,000 in the ... -
The Duff Reaction: Researching A Modification
(2014)Formylation reactions are used to synthesize aldehydes. The Duff reaction is a formylation reaction that uses phenol derivatives, hexamethylenetetramine, acetic acid, and acid to synthesis ortho substituted aromatic ... -
Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
(East Carolina University, 2015)Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ... -
ELECTROCHEMICAL DETECTION OF BENZO[A]PYRENE METABOLITE DNA DAMAGE : IMPLICATIONS OF NUCLEOBASE SEQUENCE AND ADDUCT STEREOCHEMISTRY
(East Carolina University, 2011)Xenobiotics are chemical compounds introduced to living organisms that originate outside the body. A well-studied xenobiotic is benzo[a]pyrene (BP), a polyaromatic hydrocarbon (PAH) primarily introduced into the body via ... -
Electrochemical Detection of Benzo[a]Pyrene-Induced DNA Damage at TP53 Oligomers : Impact of 5'-Methyl Cytosine and Bioactivation on the Genotoxicity Process
(East Carolina University, 2014)DNA houses the blueprint that dictates how an organism will develop. However, DNA features numerous reactive sites that can be attacked by chemicals and radiation, resulting in DNA damage and possibly mutations. Chemical ... -
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ... -
Extraction of Salvia miltiorrhiza Using Subcritical Water
(2014)Salvia miltiorrhiza, also known as Danshen, is an herb commonly used in Chinese medicine to treat cardiovascular and other diseases. As it has recently gained more recognition, this herb is currently being investigated for ... -
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
(East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
KINETIC MODELING OF DISSOLUTION AND CRYSTALLIZATION OF BATCH REACTIONS WITH IN SITU SPECTROSCOPIC MEASUREMENTS
(East Carolina University, 2012)The use of Process Analytical Technology (PAT) recommended by the Food and Drug Administration (FDA) has significantly increased during the past years in the design, control and monitoring of pharmaceutical or chemical ... -
Molecular Dynamics Studies of Point Mutations of Cardiac Troponin C and Annexin
(East Carolina University, 2015)Calcium binding proteins are biologically important for their ability to convert changes in calcium ion concentration to functional changes in proteins. All calcium binding proteins use a calcium sensing motif that changes ... -
Oxidation of Isoprene to Methyl vinyl ketone and Methacrolein via Hydroxyl Radical : A Regenerative Mechanism for the Hydroxyl Radical
(East Carolina University, 2013)Isoprene is an important molecule in atmospheric chemistry. Belonging to a class of molecules known as volatile organic compounds, it undergoes reactions with several different oxidizers in the atmosphere, including ... -
SEPARATION AND ANALYSIS OF PRESERVATIVES IN SKINCARE CREAMS BY HIGH TEMPERATURE LIQUID CHROMATOGRAPHY AND SUBCRITICAL WATER CHROMATOGRAPHY
(East Carolina University, 2011)Preservatives are chemicals with antimicrobial activity commonly added to foods, pharmaceuticals and cosmetics in order to prolong products' shelf life and to protect the consumer from potential infection. Parabens, the ... -
Solvent and Solubility Effects on Quinone Ratios
(East Carolina University, 2012)Monoquinones and diquinones are a biologically and chemically important class of compounds that can be found in numerous natural products such as: thymoquinone, oosporein, coenzyme Q, embelin and the respective dimer, ...