Browsing by Subject "Epigenetics"
Now showing items 1-10 of 10
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A metabolomics approach to understanding recurrent stroke risk in African Americans
(East Carolina University, 2019-07-02)Stroke is a significant health burden, as the fifth leading cause of death and the number one cause of serious, long term disability in the United States. Each year 795,000 individuals suffer a stroke; of which 185,000 ... -
Epigenetic Effect of Modified Diet and Exercise on Drosophila Metabolic Phenotype and Cardiovascular Health
(2015-04)Obesity is a growing world-wide epidemic. Overweight populations are prone to a variety of morbid conditions including diabetes type 2, cardiovascular diseases, and cancers. The catastrophic increase in obesity rates, which ... -
EXERCISE AND DIET PROGRAMS DROSOPHILA SIMULANS OFFSPRING METABOLIC PHENOTYPE
(East Carolina University, 2021-04-23)Obesity in pediatric patients has increased significantly in recent decades, along with susceptibility to Type 2 Diabetes (T2D), cardiovascular disease, cancer, and mortality. The relative contribution of genetic and ... -
Integrative multi-omic analyses identify novel biomarkers for recurrent stroke in participants from the Vitamin Intervention for Stroke Prevention (VISP) clinical trial
(East Carolina University, 2019-05-01)Background: Recurrent strokes are deadlier and more disabling than primary strokes and over 185,000 individuals in the US suffer a recurrent event each year. Current diagnostic and at-risk identification tools are inadequate ... -
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
(2015-07)Background Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter ... -
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ... -
Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs
(2014-12-17)Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
The Effects of Nicotine on Histone Modifications in Carnorhabditis Elegans
(2017-07-13)Early development stages have been known to be very susceptible to certain types of stress. Tobacco smoke is one of these major stresses that will affect them during this stage and can increase how likely they are to become ... -
Vectors of transmission: An early nicotine puff triggers a long-lasting microRNA molecular “memory” in C. elegans.
(East Carolina University, 2016-06-16)The prevalence of passive and active nicotine exposure among neonates, children and adolescents remains relatively high and varies among cultures and countries. Currently, there is ample evidence that a safe nicotine dose ...