Browsing by Subject "Metabolism"
Now showing items 1-9 of 9
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Central α-Klotho is a Novel Regulator of Arcuate Neurons and Peripheral Metabolism
(East Carolina University, 2021-04-20)The arcuate nucleus of the hypothalamus (ARC) is a critical nexus of neuron populations that interpret peripheral signals of energy status and deliver diverse efferent outputs to metabolically active tissues. These neurons ... -
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
(East Carolina University, 2017-06-22)Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system (CNS). In this study, we characterized and examined the early metabolic changes of the triple transgenic Alzheimer's disease ... -
Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
(East Carolina University, 2009)The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ... -
Epigenetic Effect of Modified Diet and Exercise on Drosophila Metabolic Phenotype and Cardiovascular Health
(2015-04)Obesity is a growing world-wide epidemic. Overweight populations are prone to a variety of morbid conditions including diabetes type 2, cardiovascular diseases, and cancers. The catastrophic increase in obesity rates, which ... -
Intramuscular lipid oxidation and obesity
(East Carolina University, 2008-04)There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging ... -
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
(2014-06)MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...