Browsing by Subject "Oogenesis"
Now showing items 1-11 of 11
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Adamts9 is critical for the development of primary ovarian follicles
(East Carolina University, 2022-07-19)Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. ... -
DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis
(East Carolina University, 2010-04-15)Public concerns on phthalates distributions in the environment have been increasing since they can cause liver cancer, structural abnormalities and reduce sperm counts in male reproductive system. However, few data are ... -
Determining the role of the steroid hormone ecdysone in critical stages of Drosophila melanogaster early oogenesis
(East Carolina University, 2019-11-27)Reproductive function in many organisms, including Drosophila melanogaster, is controlled by steroid hormones. The main steroid hormone in Drosophila is ecdysone, which is structurally and functionally similar to estrogen. ... -
Evaluating The Essential Functions Of The Replication Factor Mcm10 In Drosophila Melanogaster
(East Carolina University, 2015)Often referred to as miraculous, life as we know depends not upon miracles but on a series of highly orchestrated and regulated biochemical processes collectively known as the cell cycle. It is through these series of ... -
A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm
(East Carolina University, 2009-05-15)Fertility and embryonic viability are measures of efficient germ cell growth and development. During oogenesis and spermatogenesis, new proteins are required for both mitotic expansion and differentiation. Qualitative and ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the role of transcription factor, Trl, during germline development in the Drosophila ovary
(East Carolina University, 2019-07-22)Oogenesis is the process by which an egg develops from undifferentiated cells in the ovary. The Drosophila melanogaster ovary is an assembly line for egg production, making it a great system to investigate initial oocyte ... -
Mechanisms of germ cell development in Drosophila oogenesis.
(East Carolina University, 2018-07-17)Germ cell development requires interplay between factors that control cell fate and division. Early in their development, germ cells are an interconnected group of mitotically dividing cells. Key regulatory events then ... -
Novel roles for ecdysone receptor in the Drosophila germline
(East Carolina University, 2022-07-01)Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for ... -
Somatic steroid hormone signaling promotes early oocyte polarization in Drosophila
(East Carolina University, 2021-07-28)In the ovary, oogenesis depends on intercellular communication between somatic and germ cell populations for proper oocyte production. Steroid hormone signaling, well-described for its diverse roles throughout oogenesis, ... -
The small GTPase Ran and β-importins Tnpo-SR and Cadmus promote ovarian cyst formation in Drosophila
(East Carolina University, 2021-06-14)Germ cells follow a precise and coordinated molecular timeline to produce a viable oocyte. While undergoing mitotic expansion via incomplete cytokinesis, cysts of undifferentiated cells form and remain interconnected prior ...