Browsing by Subject "Osteoarthritis"
Now showing items 1-11 of 11
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CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
Domain Specific Self-Efficacy Mediates the Impact of Pain Catastrophizing on Pain and Disability in Overweight and Obese Osteoarthritis Patients
(East Carolina University, 2008-10)This study examined whether self-efficacy mediated the relationship between pain catastrophizing and pain and disability. Participants were 192 individuals diagnosed with osteoarthritis (OA) of the knees who were overweight ... -
The Effects of Quadriceps Strengthening Exercise on Quadriceps Muscle Biomechanics During Locomotion in Adults with Knee Osteoarthritis
(East Carolina University, 2013)Knee Osteoarthritis (OA) is a disease characterized by knee joint deterioration and pain, while also being associated with altered knee joint mechanics and quadriceps strength deficits. Research investigating the effects ... -
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ... -
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
(East Carolina University, 2009-07-28)Background: Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently ... -
KNEE JOINT LOADING MAGNITUDE, DISTRIBUTION, AND ASYMMETRY WITH VEST-BORNE LOADS
(East Carolina University, 2022-06-03)INTRODUCTION: Chronic exposure to high tibiofemoral joint (TFJ) loads can be detrimental to knee joint health and lead to the onset of osteoarthritis (OA). Soldiers who carry heavy loads have greater risk for onset of OA. ... -
Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial
(2016-08-23)Background: African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has been ... -
SHORT STEP KNEE OSTEOARTHRITIS: A BEGINNERS GUIDE TO RUNNING POST ACLR
(East Carolina University, 2016-06-01)Introduction: Post anterior cruciate ligament reconstruction (ACLR), individuals are 3-4x more likely to develop knee osteoarthritis (OA). Increased knee joint loads, and knee joint loading characteristics have been ...