Browsing by Subject "inflammation"
Now showing items 1-8 of 8
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Breaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune Perspectives
(2010-08)Diseases rarely, if ever, occur in isolation. Instead, most represent part of a more complex web or “pattern” of conditions that are connected via underlying biological mechanisms and processes, emerge across a lifetime, ... -
Can GPR4 Be a Potential Therapeutic Target for COVID-19?
(2021-01-21) -
Can GPR4 be a potential therapeutic target for COVID-19?
(2021-01-21)Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in late 2019 and has since rapidly become a global pandemic. SARS-CoV-2 infection causes damages to ... -
Effects of Weight Loss and Exercise on GlycA Levels in Middle-Aged Adults
(East Carolina University, 2021-05-03)GlycA is a novel inflammatory biomarker that measures systemic inflammation. Inflammation accompanies atherosclerosis, leading to cardiovascular disease (CVD). The effects of a combined exercise-plus-diet intervention on ... -
Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium
(2013-05)Background: Engineered nanomaterials (ENMs) have potential benefits, but they also present safety concerns for human health. Interlaboratory studies in rodents using standardized protocols are needed to assess ENM ... -
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
Prohibitin: A novel regulator of inflammatory cell dynamics
(East Carolina University, 2020-02-04)Inflammation is a complex mechanism primarily driven by the immune system to eradicate pathogens/foreign substances and restore tissue homeostasis. Despite the beneficial effects that inflammation employs, signaling can ... -
The M2a macrophage phenotype accompanies pulmonary granuloma resolution in Mmp12 knock-out mice instilled with multiwall carbon nanotubes
(MDPI, 2021-10-13)Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, ...