Browsing Physiology by Title
Now showing items 1-20 of 151
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
(East Carolina University, 2020-12-17)Cardiovascular disease (CVD) is the primary cause of death in the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains ... -
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ... -
Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model
(East Carolina University, 1995-07)The ability of allopurinol to protect against reperfusion injury in the heart has usually been attributed to its xanthine oxidase (XO)- inhibiting properties. Human myocardium how- ever, has exhibited low levels of XO ... -
Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
(East Carolina University, 1997-03)Intravenous (i.v.) administration of phagocytosable chitin particles (1 to 10 mm) in C57BL/6 mice and SCID mice primed alveolar macrophages (Mf) within 3 days to yield up to a 50-fold increase in their oxidative burst when ... -
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides Aβp3-42 and Aβp11-42. The ... -
Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging
(2018-01-05)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells
(East Carolina University, 2009-02)Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has ... -
Apparatus and method for measuring physiological characteristics of an intact trachea in vitro
(2011-03-15)Apparatus and methods for measuring smooth muscles responses (relaxation and contraction), transepithelial potential difference, and/or transepithelial impedance of an intact trachea in vitro. In particular embodiments, ... -
Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries
(East Carolina University, 2009-04)Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ... -
Augmented coronary vascular smooth muscle response to endothelin-1 exacerbates cardiac injury following pulmonary exposure to engineered nanomaterials
(East Carolina University, 2014)Multi-walled carbon nanotubes (MWCNT) and 60-carbon fullerenes (C60) are important engineered nanoparticles (ENP) used across industry. Exposure to ENP potentially promotes cardiovascular detriments. The hypotheses that ... -
The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
(2014-09)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ...