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THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
(East Carolina University, 2019-07-26)Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
(East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ... -
Targeting Psychological Flexibility in Youth to Enhance Health-Related Behaviors
(East Carolina University, 2019-07-22)Background: Adolescents are uniquely vulnerable to a wide range of psychological issues and often, concerns inadequately addressed. When addressed, mental health concerns are commonly handled in schools, which are uniquely ... -
Examination of Nutrition Monitoring through Ecological Momentary Assessment during an Internet-based, Self-directed Weight Loss Intervention
(East Carolina University, 2019-07-09)Internet and mobile health (mHealth) based interventions are promising potential options for increasing access to weight loss treatment for the general public (Payne et al., 2015). Many health-related internet and mobile ... -
Interim Assessments as a Predictive Tool and Driver of Formative Assessment Practices to Improve Student Performance on State Assessments
(East Carolina University, 2019-07-08)The problem of practice on which this study focused was the establishment of interim assessments as a predictive tool and driver of formative assessment practices to improve student performance. The initial phase of the ... -
On Edge: A Techné of Marginality
(East Carolina University, 2019-07-24)Technical and professional communication has traditionally been rooted in the white, Western, hetero-patriarchal rhetorical tradition and bound by rigid notions of objectivity and neutrality that exclude historically ... -
THE EFFECTIVENESS OF JOB CARD GROUNDING IN AN INTERMEDIATE CARE FACILITY FOR INDIVIDUALS WITH INTELLECTUAL DISABILITY
(East Carolina University, 2019-08-05)Despite limited research, Job Card Grounding (JCG) remains a highly recommended clinical intervention for defiant adolescents, with many medical and parenting websites advocating for its use. The purpose of the current ... -
The effects of stress on avian gene expression and microbiomes
(East Carolina University, 2019-07-24)Organisms must cope with stressors throughout their lifetime. Stressors are broad and come from both intrinsic and extrinsic sources. In this era of rapid global change, exposure to stressors will become more unpredictable ... -
Nontraditional Pathways to the University Presidency: The Lived Experiences of Contemporary Chancellors in the University of North Carolina System
(East Carolina University, 2019-07-16)ABSTRACT Glen Gordon Burnette III, NONTRADITIONAL PATHWAYS TO THE UNIVERSITY PRESIDENCY: THE LIVED EXPERIENCES OF CONTEMPORARY CHANCELLORS IN THE UNIVERSITY OF NORTH CAROLINA SYSTEM (Under the direction of Dr. Crystal ... -
Novice Teachers’ Preparedness Towards Successfully Interacting with Culturally Diverse Student Populations
(East Carolina University, 2019-07-15)Teacher effectiveness is the most influential factor to student achievement. Systems of public education in the United States have traditionally centered on White, middle class norms, as suggested by the founding arguments ... -
Editorial Peer Review as a Content-Shaping Mechanism in Technical Communication Journal Scholarship
(East Carolina University, 2019-07-19)Editorial peer review serves multiple functions in academic journal publishing including gatekeeping, quality control, and mentoring. As representatives of a discipline and its body of knowledge, peer reviewers evaluate ... -
The Impact of Comorbid Anxiety on College Student Response to an ADHD Coaching Treatment
(East Carolina University, 2019-07-09)Attention-deficit/hyperactivity disorder (ADHD) creates profound impairments. Even when K-12 school-based interventions are successful and students with ADHD matriculate to college, there is a high likelihood of college ... -
MINORITY STRESS, RISKY BEHAVIORS, AND SEXUAL SCRIPTING AMONG TRANSGENDER COLLEGE STUDENTS: A MIXED METHODS STUDY
(East Carolina University, 2019-07-11)Despite more transgender and gender nonconforming students entering college, little is known about their minority stress and resilience experiences or about how minority stress and resilience factors influence their sexual ... -
Investigation of the Anatomical and Physiological Changes Following the Use of a Pedicled Buccal Fat Pad Graft During Primary Palatoplasty
(East Carolina University, 2019-07-19)Children with cleft palate typically undergo primary surgery between 6-12 months of age to close the cleft in the palate and create proper muscle function for elevation and retraction of the velum for speech. About one ... -
EFFECTS OF CANNABIDIOL ON VOCAL LEARNING AND RECOVERY FROM CNS DAMAGE
(East Carolina University, 2019-06-19)Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and was recently effective for the treatment of childhood seizures caused by Dravet and ... -
Generation of Pseudo-CT using Two Sets of MRI Scans for MRI-only Radiation Therapy
(East Carolina University, 2019-07-16)WWith increasing interests in magnetic resonance imaging (MRI)-only radiation therapy (RT) and the emergence of MRI system integrated with the linear accelerator, a method substituting the computed tomography (CT) in ... -
FETUS PHANTOM CONSTRUCTIONS FOR OVERWEIGHT AND OBESE PREGNANT FEMALES FOR RADIOLOGICAL APPLICATIONS
(East Carolina University, 2019-06-07)Radiation exposure and associated radiation risks are major concerns for fetal development for pregnant patients in general, and in particular for overweight and obese pregnant patients who undergo diagnostic imaging or ... -
Y’all Call it Technical and Professional Communication, We Call it #ForTheCulture: The Use of Amplification Rhetorics in Black Communities and their Implications for Technical and Professional Communication Studies
(East Carolina University, 2019-07-23)This project seeks to define and identify the use of Amplification Rhetorics (AR) in the social movement organization TRAP Karaoke and at three Historically Black Colleges and Universities (HBCUs). In highlighting the ...