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Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)Skeletal muscle-specific ERα appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ERα is critical ... -
Human T-Cell Leukemia Virus Type I Basic Leucine Zipper Factor (HBZ) Modulates Cellular DNA Damage Repair and Antioxidant Responses to Promote Host Cell Survival and Leukemogenesis
(East Carolina University, 2018-04-19)Approximately twenty million people worldwide are infected with Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 establishes a life-long, chronic infection which can result in the development of severe HTLV-1 associated ... -
Adaptations of the Hypothalamic Arcuate Nucleus in Response to Exercise and Hunger
(East Carolina University, 2018-05-02)The arcuate nucleus of the hypothalamus serves as a critical node for regulation of mammalian energy balance with the ability to sense the status of many organ systems and exert control over effector arms that potently ... -
Adverse Childhood Experiences and Disordered Eating in the Military
(East Carolina University, 2018-05-01)Over the last two decades, researchers, clinicians, and policy makers have increasingly acknowledged the impact of adverse childhood experiences (ACEs; Felitti et al., 1998) on adult health outcomes. Although the prevalence ... -
AMINO ACID BINDING TO AFLATOXIN B1 DURING A NOVEL FOOD TREATMENT PROCESS PROTECTS AGAINST GENOTOXICITY
(East Carolina University, 2018-04-19)Access to clean food is a crucial factor in maintaining public health. Contamination of food supplies with toxic substances can lead to a myriad of health issues. As a mycotoxin, aflatoxin B1 (AFB1) is a naturally occurring ... -
Health and Well-Being of Physical Trauma Survivors: Who Follows Up?
(East Carolina University, 2018-04-23)Given the growing number of physical trauma survivors, it is imperative that mental health clinicians, medical providers, researchers, and policy makers are aware of their unique biological, psychological, and social health ... -
INCREASING AFRICAN AMERICAN ADVANCED STEM PROFESSIONALS: A CASE STUDY OF TWO PREDOMINANTLY WHITE FLAGSHIP UNIVERSITIES IN THE SOUTH
(East Carolina University, 2018-04-23)This qualitative multiple-case study explores how two select predominantly white institutions (PWIs) have learned to be successful in advancing undergraduate African-American students to advanced degrees in the life sciences. ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
RELEASE FROM MASKING: BEHAVIORAL AND ELECTROPHYSIOLOGICAL MEASURES IN YOUNG AND OLDER LISTENERS
(East Carolina University, 2018-04-19)Difficulty listening to speech under challenging conditions is the main complaint of audiology patients. Researchers have explored the cause of this concern, however, many questions are left unanswered. The primary concern ... -
INFLUENCE OF PHYSICOCHEMICAL PROPERTIES OF SILVER NANOPARTICLES ON MAST CELL AND MACROPHAGE UPTAKE AND ACTVATION: ROLE OF SCAVENGER RECEPTOR B1
(East Carolina University, 2018-04-09)Silver nanoparticles (AgNPs) are widely used in consumer products and the medical field for their antimicrobial properties. Some studies reported toxic effects of AgNPs but cellular uptake of AgNPs and AgNP-induced ... -
OPENING DOORS THROUGH INSTRUCTIONAL COACHING: EXPLORING HOW SOCIAL CAPITAL THEORY ENHANCES COLLEGIAL FOCUS AND INTENTIONAL STRUCTURES IN AN INSTRUCTIONAL COACHING MODEL
(East Carolina University, 2018-03-14)Teachers working in silos and in isolation from their colleagues characterize how we have always done business in education. Closed classroom doors are the norm. In today's educational environment of high stakes ... -
The Effects of School Based Intervention Programs On Student Achievement at a Northeastern North Carolina Early College High School
(East Carolina University, 2018-04-17)The purpose of this study was to examine the effects of four school-based programs on student academic performance at an early college high school in northeastern North Carolina. The four school-based intervention programs ... -
The Psychosocial Implications of Being Lesbian, Gay, and Bisexual Military Personnel in a Post Don't Ask, Don't Tell Era
(East Carolina University, 2018-04-24)Scholarly research on sexual minority military personnel was silenced until the United States (U.S.) Congress passed the Don’t Ask, Don’t Tell (DADT) Repeal Act of 2010. Not only did the repeal liberate lesbian, gay, and ... -
IMPROVING LEARNING THROUGH PRINCIPAL PROFESSIONAL LEARNING COMMUNITIES
(East Carolina University, 2018-04-09)This dissertation examines how the creation of a Principal Professional Learning Community (PPLC) including principals at two high performing schools (STEM High and Early College High) and principals at two low performing ... -
Biopsychosocial Barriers, Motivational Interviewing, and Antiretroviral Medication Adherence in Persons Living with HIV and AIDS
(East Carolina University, 2018-04-23)Since the development of antiretroviral medications in the mid-1990s, treatment of human immunodeficiency virus (HIV) infection has improved steadily and HIV is now considered a manageable chronic condition with improved ... -
AN EVALUATION OF AN ALTERNATIVE PROGRAM IN PENDER COUNTY
(East Carolina University, 2018-04-11)The purpose of this problem of practice was to conduct an evaluation of the Pender County Alternative School, Students Taking Alternative Routes Academy (STAR). The evaluation was conducted using the Empowerment Evaluation ... -
THE IMPROVEMENT OF A BEGINNING TEACHER SUPPORT PROGRAM TO ENHANCE TEACHER RETENTION
(East Carolina University, 2018-04-18)This study was designed to improve the current beginning teacher support program and address the problem of beginning or early career teachers leaving the district. Researchers have found that as many as 50% of teachers ... -
A Program Evaluation of the Multi-Tiered System of Support in Pamlico County Schools
(East Carolina University, 2018-04-18)Over the past six years, student proficiency in reading has been a problem in the Pamlico County School District. To address this problem an instructional framework known as Multi-Tiered System of Support (MTSS) was ... -
A PROGRAM EVALUATION OF THE LEARNING FOCUSED MODEL IN CRAVEN COUNTY
(East Carolina University, 2018-04-18)This program evaluation was to provide guidance to school officials for future decisions regarding the Learning Focused Solutions Model. The program evaluation was conducted using the evaluation design by Daniel Stufflebeam ... -
Reshaping School Culture to Maximize Student Achievement
(East Carolina University, 2018-03-29)The issue that my study addressed was the declining culture of Suburban Middle School, (SMS) a pseudonym used to describe a large suburban middle school in southeastern North Carolina. Declining or stagnant test scores ...