Dissertations
Recent Submissions
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UNDERSTANDING THE ROLE OF RAB10 IN NEURONAL RESILIENCE
(East Carolina University, 2023-12-08)Neuroresilience refers to the remarkable capacity of the brain to maintain its normal functioning and safeguard against cognitive decline even in the face of stress or trauma. The exploration of genes and pathways that ... -
PSYCHOLOGICAL IMPACT OF PROSTHETIC JOINT INFECTIONS FOLLOWING TOTAL HIP AND KNEE REPLACEMENT
(East Carolina University, 2023-12-06)Background. Prosthetic Joint Infection (PJI) is a devastating complication of total joint arthroplasty (TJA) with a relative survival rate worse than that of prostate cancer, melanoma, and breast cancer. This study explores ... -
A Multi-Compartmental Investigation of Bcl-2 Associated Athanogene 3 (BAG3) in Peripheral Artery Disease
(East Carolina University, 2023-12-13)Peripheral artery disease (PAD) is caused by an atherosclerotic blockage to a vessel that restricts blood flow to the lower extremity. Chronic limb threatening ischemia (CLTI) is the most severe manifestation of PAD, and ... -
MODULATING MMP-9 SUBSTRATE PREFERENCE TO REDUCE INFLAMMATION POST-MI
(East Carolina University, 2023-12-08)Worldwide, the prevalence of cardiovascular disease (CVD) is escalating, with myocardial infarction (MI) significantly contributing to the heightened rates of morbidity and mortality. Notably, one in every four MI patients ... -
Identification of galectin-1 as a marker for claudin-low breast cancer and implications for tumor progression
(East Carolina University, 2024-01-04)Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have a high rate of metastasis and mortality due to the lack of targeted therapies and resistance to chemotherapy. This ... -
STUDENT TRAJECTORIES RELATED TO READING AND ATTENTION SKILLS: IS THERE EVIDENCE OF THE MATTHEW EFFECT?
(East Carolina University, 2024-01-04)Research on reading is widespread given its predictive nature for adult outcomes pertaining to success, such as high school graduation, college entrance, health literacy, employment status and wages earned. Research focusing ... -
The importance of land use on public health. Case studies from the Rivanna River Watershed.
(East Carolina University, 2023-12-11)Introduction: Safe and reliable water is vital to sustaining the environment and human health. However, factors including an expanding population, aging infrastructure, climate change, emerging contaminants, nonpoint source ... -
NITROGEN AND BACTERIA TREATMENT EFFICIENCY OF ONSITE WASTEWATER SYSTEMS IN THE PIEDMONT OF NORTH CAROLINA
(East Carolina University, 2023-12-01)Onsite wastewater treatment systems (OWTSs) are commonly used in rural areas for wastewater disposal. These systems can contribute elevated concentrations of nutrients and bacteria into water resources, resulting in potential ... -
Addressing Rising Hospital Acquired Infections (HAIs) Using Novel Nanotechnology: Implications for Public Health Protection
(East Carolina University, 2023-12-11)Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to lower efficacy of current antibiotic therapy. Specifically, Hospital Acquired Infections ... -
HUMAN HEALTH EFFECTS OF LEAD IN THE ENVIRONMENT: A MULTI-SOURCE APPROACH OF ELEVATED LEAD EXPOSURE AMONG AT-RISK POPULATIONS IN PITT COUNTY, NORTH CAROLINA, USA
(East Carolina University, 2023-12-05)Despite lead (Pb) in public drinking water has been studied extensively, Pb in homes has received less attention. Elevated Pb level in homes is a growing public health concern as Pb exposure in children is known to cause ... -
ANALYSIS OF COMMUNITY HEALTH WORKER’S SELF-DEFINED ATTITUDE, BEHAVIOR, AND EXPERIENCE REGARDING INTERPROFESSIONAL COLLABORATION
(East Carolina University, 2023-11-30)Evidence suggests that the role of community health workers (CHWs) continues to evolve in support of the demand to address social determinants of health, prevention, cost, and population health. The aim of this mixed-methods ... -
FEEDING KNOWLEDGE AND FEEDING CONFIDENCE OF PROFESSIONAL GROUPS IN EASTERN NORTH CAROLINA WHO ARE INVOLVED IN PROVIDING PRENATAL CARE VISITS FOR PARENTS HAVING A BABY DIAGNOSED WITH CLEFT LIP WITH OR WITHOUT CLEFT PALATE
(East Carolina University, 2023-11-29)Objective: This study aimed to evaluate the feeding knowledge and feeding confidence of different professional groups in eastern North Carolina who provided prenatal care visits (PNVs) for parents having a baby diagnosed ... -
Investigating the genetic basis of aposematic coloration in poison frogs
(East Carolina University, 2023-11-29)Aposematic organisms rely on their conspicuous appearance to signal that they are defended and unpalatable. Such phenotypes are strongly tied to survival and reproduction. Aposematic colors and patterns are highly variable; ... -
SPATIAL AND PLANAR DYSREGULATION OF RHOGTPASES IN HUMAN AND ALZHEIMER’S DISEASE MOUSE MODEL
(East Carolina University, 2023-11-27)Rho proteins belong to the Ras superfamily of small GTPases. In humans, the Rho family of GTPases contains 20 members out of which the most studied Rho proteins are RhoA, Rac1, and Cdc42. Rho signaling is known to regulate ... -
Age-Related Diagnostic Considerations and Neurocognitive Impairment Implications for Insomnia Disorder
(East Carolina University, 2023-12-01)Insomnia affects 10-30% of the U.S. population and can be found across varying stages of life. While it has previously been shown that the addition of quantitative indices would be helpful for distinguishing between sleep ... -
Adapt & Overcome: Hypoxia Resistance is a Novel Phenotype of the Flexor Digitorum Brevis Skeletal Muscle
(East Carolina University, 2023-11-30)Skeletal muscle comprises the largest mammalian organ system by mass that enables movement, respiration, and thermogenesis. Each of these processes requires the presence of molecular oxygen (O2). Inadequate O2 bioavailability ... -
A UNIQUE MITOCHONDRIAL BIOENERGETIC PATHWAY UNDERLIES ACUTE MYELOID LEUKEMIA SURVIVAL AND CHEMORESISTANCE
(East Carolina University, 2023-12-01)In his early research on cancer cell metabolism, Otto Warburg made the hypothesis that the respiration of cancer cells has become damaged. The insult to cancer cell respiration, Warburg proposed, was either 1) a decrease ... -
IMPLEMENTATION OF A PARENT-LED COMBINED GROWTH-MINDSET AND HOME LITERACY INTERVENTION: A PILOT STUDY
(East Carolina University, 2023-11-30)This pilot study examined the implementation feasibility and preliminary effectiveness of a combined growth-mindset and literacy intervention delivered in the home by parents and guardians. The study was completed in two ... -
Feasibility and Acceptability of a Values-Based Telehealth Intervention to Promote Adherence in Cardiopulmonary Rehabilitation Patients
(East Carolina University, 2023-12-07)Background: Current research indicates an ongoing need to identify interventions to promote Cardiopulmonary Rehabilitation (CVPR) participation, as participation in CVPR remains low despite positive effects on health ... -
Comparing Clinical Judgment Competency Between Accelerated and Traditional Bachelor of Science in Nursing Students during High-fidelity Simulation
(East Carolina University, 2023-12-01)ABSTRACT Background: Evidence suggests that competency in clinical judgment may be lacking in new graduate nurses. Graduates from accelerated baccalaureate nursing (ABSN) programs have even less time to develop clinical ...