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NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction, Peripheral, and Coronary Endothelial Dysfunction in Obesity
(East Carolina University, 2012)
Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ...
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)
The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ...
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)
Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ...
The lived experience of obese employees who discontinued voluntary participation in a workplace weight loss challenge program : A qualitative study
(East Carolina University, 2014)
This phenomenological qualitative study, guided by Max van Manen, addressed the question, "What is the lived experience of obese employees who discontinued participation in a workplace weight loss challenge program in which ...
Prevalence of overweight and obesity, and dieting attitudes among Caucasian and African American college students in Eastern North carolina: A cross-sectional survey
(East Carolina University, 2010-02)
A cross-sectional survey was used to investigate the rates of overweight and obesity (BMI greater than or equal to 25), and eating attitudes among college students. Data were collected at a large southeastern university. ...
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
(East Carolina University, 2009-07-28)
Background: Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently ...
SKELETAL MUSCLE LIPID PARTITIONING : CONSEQUENCES OF ALTERATIONS IN ACYL-COA SYNTHETASE-5 AND DIGLYCERIDE ACYLTRANFERASE-1 EXPRESSION
(East Carolina University, 2011)
An oversupply of fatty acids and inadequacies in their partitioning toward oxidation and/or storage will lead to disruptions in cellular homeostasis. Reductions in mitochondrial content and lower rates of fatty acid ...
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
(East Carolina University, 2009-01)
OBJECTIVE- Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, ...
The Influence of BMI and Self-Efficacy Levels on the Accuracy in Self-Reported Physical Activity Recall
(East Carolina University, 2011)
The purpose of this study was to compare self-reported and objectively measured physical activity levels among college students with different body mass index (BMI) classifications (normal weight and overweight/obese), in ...
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)
Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...