Author | Karschner, Vesna Ann | en_US |
Author | Pekala, Phillip H. | en_US |
Date Accessioned | 2010-12-10T14:07:28Z | en_US |
Date Accessioned | 2011-05-17T01:27:04Z | |
Date Available | 2010-12-10T14:07:28Z | en_US |
Date Available | 2011-05-17T01:27:04Z | |
Date of Issue | 2009-05-29 | en_US |
Identifier (Citation) | Biochemical and Biophysical Research Communications; 383:2 p. 203-205 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3026 | en_US |
Description | In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the message to the cytosol, stabilization of the mRNA and/or altering its translational efficiency. Suppression of HuR using siRNA resulted in an attenuation of the 3T3-L1 differentiation program, consistent with HuR control of the expression of mRNA ligand (s) critical to the differentiation process. In the current study we begin to identify mRNA ligands of HuR whose regulated expression is necessary for adipogenesis. Originally published in Biochemical and Biophysiological Research Communications Vol. 383, No. 2 2009. | en_US |
Language | en_US | en_US |
Publisher | East Carolina University | en_US |
Related URI | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4W0SJXH-7&_user=634873&_coverDate=05%2F29%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=33bac885d3c5d742e3a65cbe1ba906cd&searchtype=a | en_US |
Subject | Adipogenisis | en_US |
Subject | Differentiation | en_US |
Subject | 3T3-L1 | en_US |
Subject | HuR | en_US |
Subject | Elav | en_US |
Subject | SiRNA | en_US |
Subject | β-actin | en_US |
Subject | p53 | en_US |
Subject | [Beta]-actin | |
Title | HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype | en_US |
Type | Article | en_US |
Identifier (PMID) | PMC2693087 | en_US |
Identifier (DOI) | 10.1016/j.bbrc.2009.03.152 | |
Journal Name | Biochemical and Biophysical Research Communications | |
Journal Volume | 383 | |
Journal Issue | 2 | |
Article Pages | 203-205 | |