Author | Kim, Hangun | en_US |
Author | Oh, Minsoo | en_US |
Author | Lu, Qun | en_US |
Author | Kim, Kwonseop | en_US |
Date Accessioned | 2011-04-15T15:08:24Z | en_US |
Date Accessioned | 2011-05-17T13:03:53Z | |
Date Available | 2011-04-15T15:08:24Z | en_US |
Date Available | 2011-05-17T13:03:53Z | |
Date of Issue | 2008-12-12 | en_US |
Identifier (Citation) | Biochemical and Biophysical Research Communications; 377:2 p. 636-641 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3322 | en_US |
Description | δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe
distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial
cells. In HEK293 cells maintained in low cell densities, approximately 15% of cells overexpressing
δ-catenin showed dendrite-like process formation, but there was no detectable change in RhoA
activity. In addition, δ-catenin was localized mainly in the cytoplasm and was associated with
p190RhoGEF. However, at high cell densities, δ-catenin localization was shifted to the plasma
membrane. The association of δ-catenin with E-cadherin was strengthened, whereas its interaction
with p190RhoGEF was weakened. In mouse embryonic fibroblast cell, ectopic expression of Ecadherin
decreased the effect of δ-catenin on the reduction of RhoA activity as well as on dendritelike
process formation. These results suggest that δ-catenin is more dominantly bound to E-cadherin
than to p190RhoGEF, and that δ-catenin’s function is dependent on its cellular binding partner. Originally published Biochem Biophys Res Commun, Vol. 377, No. 2, Dec 2008 | en_US |
Language | en_US | en_US |
Publisher | East Carolina University | en_US |
Related URI | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4TP7XD0-S&_user=634873&_coverDate=12%2F12%2F2008&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=ac22e6f78d8cffa0a0277047ee00ca6c&searchtype=a | en_US |
Rights | Author notified of opt-out rights by Cammie Jennings prior to upload of this article. | en_US |
Subject | [Delta]-catenin | en_US |
Subject | Cadherin | en_US |
Subject | Dendrogenesis | en_US |
Subject | Adherens junction | en_US |
Subject | RhoA | en_US |
Subject | δ-catenin | |
Title | E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin | en_US |
Type | Article | en_US |
Identifier (PMID) | PMC2614342 | en_US |
Identifier (DOI) | 10.1016/j.bbrc.2008.10.030 | |
Journal Name | Biochemical and Biophysical Research Communications | |
Journal Volume | 377 | |
Journal Issue | 2 | |
Article Pages | 636-641 | |