Author | Kim, Jin-Sook | en_US |
Author | Bareiss, Sonja | en_US |
Author | Kim, Kyung Keun | en_US |
Author | Tatum, Rodney | en_US |
Author | Han, Jeong-Ran | en_US |
Author | Jin, Yun Hye | en_US |
Author | Kim, Hangun | en_US |
Author | Lu, Qun | en_US |
Author | Kim, Kwonseop | en_US |
Date Accessioned | 2011-04-15T15:13:05Z | en_US |
Date Accessioned | 2011-05-17T13:03:52Z | |
Date Available | 2011-04-15T15:13:05Z | en_US |
Date Available | 2011-05-17T13:03:52Z | |
Date of Issue | 2006-12-29 | en_US |
Identifier (Citation) | Biochemical and Biophysical Research Communications; 351:4 p. 903-908 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3325 | en_US |
Description | Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that overexpression of PS-1 inhibits the delta-catenin-induced dendrite-like morphological changes in NIH 3T3 cells and promotes delta-catenin processing and turnover. The effects of PS-1 on endogenous delta-catenin processing were confirmed in hippocampal neurons overexpressing PS-1, as well as in the transgenic mice expressing the disease-causing mutant PS-1 (M146V). In addition, disease-causing mutant PS-1 (M146V and L286V) enhanced delta-catenin processing, whereas PS-1/gamma-secretase inhibitors could block the formation of processed forms of delta-catenin. Together, our findings suggest that PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. Originally published Biochem Biophys Res Commun, Vol. 351, No. 4, Dec 2006 | en_US |
Language | en_US | en_US |
Publisher | East Carolina University | en_US |
Related URI | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4M813W6-9&_user=634873&_coverDate=12%2F29%2F2006&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=714fba29e7d7e581fa9873bc56ac1f2b&searchtype=a | en_US |
Rights | Author notified of opt-out rights by Cammie Jennings prior to upload of this article. | en_US |
Subject | Alzheimer's disease | en_US |
Subject | [Delta]-catenin/NPRAP | en_US |
Subject | Presenilin/gamma-secretase | en_US |
Subject | δ-catenin/NPRAP | |
Title | Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover | en_US |
Type | Article | en_US |
Identifier (PMID) | PMC1800877 | en_US |