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    Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus

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    Author
    Hughes, Austin L.; Westover, Kristi; da Silva, Jack; O'Connor, David H.; Watkins, David I.
    Abstract
    Tat-specific cytotoxic T cells have previously been shown to exert positive Darwinian selection favoring amino acid replacements of an epitope of simian immunodeficiency virus (SIV). The region of the tat gene encoding this epitope falls within a region of overlap between the tat and vpr reading frames, and nonsynonymous nucleotide substitutions in the tat reading frame were found to occur disproportionately in such a way as to cause synonymous changes in the vpr reading frame. Comparison of published complete SIV genomes showed Tat to be the least conserved at the amino acid level of nine proteins encoded by the virus, while Vpr was one of the most conserved. Numerous parallel amino acid changes occurred within the Tat epitope independently in different monkeys, and purifying selection on the vpr reading frame, by limiting acceptable nonsynonymous substitutions in the tat reading frame, evidently has enhanced the probability of parallel evolution. Originally published Journal of Virology, Vol. 75, No. 17, Sep 2001
    URI
    http://hdl.handle.net/10342/3446
    Subject
     Simian immunodeficiency virus; Tat gene; Epitopes 
    Date
    2001-09
    Citation:
    APA:
    Hughes, Austin L., & Westover, Kristi, & da Silva, Jack, & O'Connor, David H., & Watkins, David I.. (September 2001). Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus. Journal of Virology, 75(17), 7966- 7972. Retrieved from http://hdl.handle.net/10342/3446

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Hughes, Austin L., and Westover, Kristi, and da Silva, Jack, and O'Connor, David H., and Watkins, David I.. "Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus". Journal of Virology. 75:17. (7966-7972), September 2001. February 19, 2019. http://hdl.handle.net/10342/3446.
    Chicago:
    Hughes, Austin L. and Westover, Kristi and da Silva, Jack and O'Connor, David H. and Watkins, David I., "Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus," Journal of Virology 75, no. 17 (September 2001), http://hdl.handle.net/10342/3446 (accessed February 19, 2019).
    AMA:
    Hughes, Austin L., Westover, Kristi, da Silva, Jack, O'Connor, David H., Watkins, David I.. Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus. Journal of Virology. September 2001; 75(17): 7966-7972. http://hdl.handle.net/10342/3446. Accessed February 19, 2019.
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