Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
Candido, Saverio; Maestro, Roberta; Polesel, Jerry; Catania, Alessia; Maira, Francesca; Signorelli, Santo S.; McCubrey, James A.; Libra, Massimo
Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, there is a need to identify novel factors involved in cancer development and/or progression. Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as a key player in different cancer types. Its oncogenic effect may be related to the complex NGAL/MMP-9. In the present study, NGAL was analyzed at both transcript and protein levels in different cancer types by analysing 38 public available microarray datasets and the Human Protein Atlas tool. NGAL transcripts were significantly higher in the majority of solid tumors compared to the relative normal tissues for every dataset analyzed. Furthermore, concordance of NGAL at both mRNA and protein levels was observed for 6 cancer types including bladder, colorectal, liver, lung, ovarian, and pancreatic. All metastatic tumors showed a decrease of NGAL expression when compared to matched primary lesions. According to these results, NGAL is a candidate marker for tumor growth in a fraction of solid tumors. Further investigations are required to elucidate the function of NGAL in tumor development and metastatic processes.
Candido, Saverio, & Maestro, Roberta, & Polesel, Jerry, & Catania, Alessia, & Maira, Francesca, & Signorelli, Santo S., & McCubrey, James A., & Libra, Massimo. (March 2014). Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer. Oncotarget, 5(6), 1576- 1594. Retrieved from http://hdl.handle.net/10342/5651
Candido, Saverio, and Maestro, Roberta, and Polesel, Jerry, and Catania, Alessia, and Maira, Francesca, and Signorelli, Santo S., and McCubrey, James A., and Libra, Massimo. "Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer". Oncotarget. 5:6. (1576-1594), March 2014. April 24, 2019. http://hdl.handle.net/10342/5651.
Candido, Saverio and Maestro, Roberta and Polesel, Jerry and Catania, Alessia and Maira, Francesca and Signorelli, Santo S. and McCubrey, James A. and Libra, Massimo, "Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer," Oncotarget 5, no. 6 (March 2014), http://hdl.handle.net/10342/5651 (accessed April 24, 2019).
Candido, Saverio, Maestro, Roberta, Polesel, Jerry, Catania, Alessia, Maira, Francesca, Signorelli, Santo S., McCubrey, James A., Libra, Massimo. Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer. Oncotarget. March 2014; 5(6): 1576-1594. http://hdl.handle.net/10342/5651. Accessed April 24, 2019.