Author | Abbott, Derek J. | |
Author | Blanchfield, J. Lori | |
Author | Martinson, David A. | |
Author | Russell, Sean C. | |
Author | Taslim, Najla | |
Author | Curtis II, Alan Dale | |
Author | Mannie, Mark D. | |
Date Accessioned | 2016-06-16T19:24:52Z | |
Date Available | 2016-06-16T19:24:52Z | |
Date of Issue | 2011 | |
Identifier (Citation) | BMC Immunology; 12: p. 72-72 | en_US |
ISSN | 1471-2172 | |
Identifier (URI) | http://hdl.handle.net/10342/5669 | |
Description | Background
Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models of experimental autoimmune encephalomyelitis (EAE) and thus serve as potential therapeutic modalities for multiple sclerosis.
Results
A fusion protein comprised of murine GM-CSF as the N-terminal domain and the encephalitogenic MOG35-55 peptide as the C-terminal domain was tested as a tolerogenic, therapeutic vaccine (TTV) in the C57BL/6 model of EAE. Administration of GMCSF-MOG before active induction of EAE, or alternatively, at the onset of EAE blocked the development and progression of EAE. Covalent linkage of the GM-CSF and MOG35-55 domains was required for tolerogenic activity. Likewise, a TTV comprised of GM-CSF and PLP139-151 was a tolerogen in the SJL model of EAE.
Conclusion
These data indicated that fusion proteins containing GM-CSF coupled to myelin auto-antigens elicit tolerance rather than immunity. | en_US |
Related URI | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261124/ | en_US |
Title | Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE) | en_US |
Type | Article | en_US |
Identifier (PMID) | pmc3261124 | en_US |
Identifier (DOI) | 10.1186/1471-2172-12-72 | |
Journal Name | BMC Immunology | en_US |
Journal Volume | 12 | en_US |
Article Pages | 72-72 | en_US |