Emerging targeted therapies for melanoma treatment (Review)
Russo, Angela; Ficili, Bartolomea; Candido, Saverio; Pezzino, Franca Maria; Guarneri, Claudio; Biondi, Antonio; Travali, Salvatore; McCubrey, James A.; Spandidos Demetrios A.; Libra, Massimo
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) and the PI3K/AKT (AKT) signalling pathways are constitutively activated through multiple mechanisms. Targeting various effectors of these pathways with pharmacologic inhibitors may inhibit melanoma cell growth and angiogenesis. Ongoing clinical trials provide hope to improve progression-free survival of patients with advanced melanoma. This review summarizes the most relevant studies focused on the specific action of these new molecular targeted agents. Mechanisms of resistance to therapy are also discussed.
Russo, Angela, & Ficili, Bartolomea, & Candido, Saverio, & Pezzino, Franca Maria, & Guarneri, Claudio, & Biondi, Antonio, & Travali, Salvatore, & McCubrey, James A., & Spandidos Demetrios A., & Libra, Massimo. (August 2014). Emerging targeted therapies for melanoma treatment (Review). International Journal of Oncology, 45(2), 516- 524. Retrieved from http://hdl.handle.net/10342/5673
Russo, Angela, and Ficili, Bartolomea, and Candido, Saverio, and Pezzino, Franca Maria, and Guarneri, Claudio, and Biondi, Antonio, and Travali, Salvatore, and McCubrey, James A., and Spandidos Demetrios A., and Libra, Massimo. "Emerging targeted therapies for melanoma treatment (Review)". International Journal of Oncology. 45:2. (516-524), August 2014. April 24, 2019. http://hdl.handle.net/10342/5673.
Russo, Angela and Ficili, Bartolomea and Candido, Saverio and Pezzino, Franca Maria and Guarneri, Claudio and Biondi, Antonio and Travali, Salvatore and McCubrey, James A. and Spandidos Demetrios A. and Libra, Massimo, "Emerging targeted therapies for melanoma treatment (Review)," International Journal of Oncology 45, no. 2 (August 2014), http://hdl.handle.net/10342/5673 (accessed April 24, 2019).
Russo, Angela, Ficili, Bartolomea, Candido, Saverio, Pezzino, Franca Maria, Guarneri, Claudio, Biondi, Antonio, Travali, Salvatore, McCubrey, James A., Spandidos Demetrios A., Libra, Massimo. Emerging targeted therapies for melanoma treatment (Review). International Journal of Oncology. August 2014; 45(2): 516-524. http://hdl.handle.net/10342/5673. Accessed April 24, 2019.