Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis
Author
Hoffman, William H.; Passmore, Gregory G.; Hannon, David W.; Talor, Monica V.; Fox, Pam; Brailer, Catherine; Haislip, Dynita; Keel, Cynthia; Harris, Glenn; Rose, Noel R.; Fiordalisi, Irma; Čiháková, Daniela
Abstract
Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6–12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA.
Date
2013
Citation:
APA:
Hoffman, William H., & Passmore, Gregory G., & Hannon, David W., & Talor, Monica V., & Fox, Pam, & Brailer, Catherine, & Haislip, Dynita, & Keel, Cynthia, & Harris, Glenn, & Rose, Noel R., & Fiordalisi, Irma, & Čiháková, Daniela. (January 2013).
Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis.
PLoS ONE,
8(8),
1-
13. Retrieved from
http://hdl.handle.net/10342/5749
MLA:
Hoffman, William H., and Passmore, Gregory G., and Hannon, David W., and Talor, Monica V., and Fox, Pam, and Brailer, Catherine, and Haislip, Dynita, and Keel, Cynthia, and Harris, Glenn, and Rose, Noel R., and Fiordalisi, Irma, and Čiháková, Daniela.
"Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis". PLoS ONE.
8:8. (1-13),
January 2013.
April 19, 2024.
http://hdl.handle.net/10342/5749.
Chicago:
Hoffman, William H. and Passmore, Gregory G. and Hannon, David W. and Talor, Monica V. and Fox, Pam and Brailer, Catherine and Haislip, Dynita and Keel, Cynthia and Harris, Glenn and Rose, Noel R. and Fiordalisi, Irma and Čiháková, Daniela,
"Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis," PLoS ONE 8, no.
8 (January 2013),
http://hdl.handle.net/10342/5749 (accessed
April 19, 2024).
AMA:
Hoffman, William H., Passmore, Gregory G., Hannon, David W., Talor, Monica V., Fox, Pam, Brailer, Catherine, Haislip, Dynita, Keel, Cynthia, Harris, Glenn, Rose, Noel R., Fiordalisi, Irma, Čiháková, Daniela.
Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis. PLoS ONE.
January 2013;
8(8):
1-13.
http://hdl.handle.net/10342/5749. Accessed
April 19, 2024.
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