Browsing Chemistry by Issue Date
Now showing items 21-40 of 120
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ELECTROCHEMICAL DETECTION OF BENZO[A]PYRENE METABOLITE DNA DAMAGE : IMPLICATIONS OF NUCLEOBASE SEQUENCE AND ADDUCT STEREOCHEMISTRY
(East Carolina University, 2011)Xenobiotics are chemical compounds introduced to living organisms that originate outside the body. A well-studied xenobiotic is benzo[a]pyrene (BP), a polyaromatic hydrocarbon (PAH) primarily introduced into the body via ... -
NMR Studies into the Potential Interactions of Fullerene C[subscript]60, with Tetraphenylporphyrin, H[subscript]2[TPP] and Some of its Derivatives
(East Carolina University, 2011)The curved [pi] surface of fullerene, C[subscript]60, shows a tendency to interact with other molecules, making it an interesting target for building supramolecular arrays. The interaction can be relative strong and may ... -
Design and Quantitation of Membrane Binding Lipid Anchors : Exploring Prion-Prion Interactions on Membrane Surfaces
(East Carolina University, 2011)The prion protein (PrP) is an endogenous, metal binding protein present in the neuronal cells of the central nervous system. Prion is associated with a class of neurodegenerative diseases known as transmissible spongiform ... -
SEPARATION AND ANALYSIS OF PRESERVATIVES IN SKINCARE CREAMS BY HIGH TEMPERATURE LIQUID CHROMATOGRAPHY AND SUBCRITICAL WATER CHROMATOGRAPHY
(East Carolina University, 2011)Preservatives are chemicals with antimicrobial activity commonly added to foods, pharmaceuticals and cosmetics in order to prolong products' shelf life and to protect the consumer from potential infection. Parabens, the ... -
ELECTROSPRAY IONIZATION TIME OF FLIGHT MASS SPECTROMETRY OF POLY(METHYL METHACRYLATE) AND POLYSTYRENE USING SURFACE ACTIVE QUATERNARY AMMONIUM SALTS
(East Carolina University, 2011)Electrospray ionization time of flight mass spectrometry (ESI-ToF-MS) is a powerful characterization technique for large nonvolatile compounds, but has found limited applicability in the synthetic polymer field. Two factors ... -
STABILITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND BENZOIC ACID DERIVATIVES UNDER SUBCRITICAL WATER CONDITIONS
(East Carolina University, 2011)The development of green environmental remediation, chromatography, and extraction techniques using subcritical water is the focus of our research group. The polarity of subcritical water can be manipulated by increasing ... -
Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
(East Carolina University, 2012)Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ... -
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ... -
SYNTHESIS AND PHOTOPHYSICAL CHARACTERIZATION OF TRIDENTATE C^N*N PLATINUM (II) COMPLEXES and, INVESTIGATION OF SELECTIVITY IN C-H BOND ACTIVATION BY PLATINUM
(East Carolina University, 2012)The synthesis, structure, and photophysical properties of a series of novel, highly luminescent tridentate platinum complexes with general coordination geometry of (C^N*N)-PtL are reported, where "C^N" denotes a coordination ... -
Improving the Reliability of Peptide-Zinc (II) Binding Constant Determination with Mass Spectrometry
(East Carolina University, 2012)Electrospray Ionization Mass Spectrometry (ESI-MS) has become a powerful technique for analyzing protein- and peptide-ligand interactions and quantifying their binding constants (K[subscript]b). However, ESI-MS as an ... -
Synthesis and Reactions of Novel Heteroarylzirconocene Reagents
(East Carolina University, 2012)The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerful and highly desirable transformation in both the synthesis of pharmaceutical compounds as well as materials development. ... -
KINETIC MODELING OF DISSOLUTION AND CRYSTALLIZATION OF BATCH REACTIONS WITH IN SITU SPECTROSCOPIC MEASUREMENTS
(East Carolina University, 2012)The use of Process Analytical Technology (PAT) recommended by the Food and Drug Administration (FDA) has significantly increased during the past years in the design, control and monitoring of pharmaceutical or chemical ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
(East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Thermodynamic studies of Ca²⁺ binding to human cardiac troponin C
(East Carolina University, 2012)Human Cardiac Troponin C (HcTnC) is an EF hand protein responsible for initiating contraction of the myocardium (heart muscle). The helix-loop-helix motif, characteristic of members of the EF-hand family, allows HcTnC to ... -
Kinetic Modeling of Batch Reaction Processes
(East Carolina University, 2012)Kinetic models have been demonstrated to be useful in on-line batch monitoring systems. The ability to monitor a reaction in real time is invaluable to the production process of industrial and pharmaceutical products. ... -
Solvent and Solubility Effects on Quinone Ratios
(East Carolina University, 2012)Monoquinones and diquinones are a biologically and chemically important class of compounds that can be found in numerous natural products such as: thymoquinone, oosporein, coenzyme Q, embelin and the respective dimer, ... -
Synthesis, structure, photophysics, and biological activity of platinum (II) complexes
(East Carolina University, 2013)The synthesis, structure, and photophysical properties of luminescent platinum (II) complexes with different coordination patterns, (C^C*N^N), (N^C*N), (N^N*C) and (N^N^C) are reported, where "C^N or N^N" denotes a bidentate ... -
A quantitative and nondestructive method for determining the degradation of waterlogged archaeological wood
(East Carolina University, 2013)Archaeological artifacts are an essential part of preserving history and culture, and can be valuable tools for enhancing education and contributing economic benefits through tourism. Of the artifacts that one may encounter, ... -
Oxidation of Isoprene to Methyl vinyl ketone and Methacrolein via Hydroxyl Radical : A Regenerative Mechanism for the Hydroxyl Radical
(East Carolina University, 2013)Isoprene is an important molecule in atmospheric chemistry. Belonging to a class of molecules known as volatile organic compounds, it undergoes reactions with several different oxidizers in the atmosphere, including ... -
Investigation Into Intermolecular Interactions of Gd3N@C80(OH)n Using Fluorescence Spectroscopy
(2014)The aim of this experiment was to investigate the intermolecular interactions of the endohedral metallofulerene complex in water and various metal cation solutions. These interactions were observed using a methodology ...