Browsing Health Sciences Campus by Title
Now showing items 306-325 of 564
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Leadership Boot Camp
(East Carolina University, 2006) -
Leaving No Soldier Behind: Advances and Heroism in Military Medicine
(2009-11-30)Laupus Library History Collections & the Department of Bioethics & Interdisciplinary Studies sponsor the History of Medicine Presentations as an educational service for the East Carolina University community. The Library ... -
Lesional modulation of peripheral monocyte leucotactic responsiveness in leprosy.
(East Carolina University, 1987-11)Because the accumulation and activation of mononuclear phagocytes are critical to the host response to intracellular microbial pathogens, we evaluated mechanisms of peripheral monocyte leucotactic regulation in leprosy. ... -
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.
(East Carolina University, 1996-10-01)We have previously demonstrated that chronic exposure of 3T3- L1 adipocytes to tumour necrosis factor-α (TNF) resulted in a marked decrease (~90%) in cellular GLUT4 (insulin-responsive glucose transporter) mRNA content as ... -
The lived experience of nurse practitioner graduates' transition to hospital-based practice
(East Carolina University, 2010)The purpose of this hermeneutic phenomenology (van Manen, 1990) was to gain insight into the meaning and lived experience of nurse practitioners (NP) with at least one year of work experience regarding their initial ... -
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
(East Carolina University, 2009-01-13)Persistent activation of the signal transducer and activator of transcription 3 (STAT3) signalling has been linked to oncogenesis and the development of chemotherapy resistance in glioblastoma and other cancers. Inhibition ... -
Local Anesthetic Adjuvants Providing the Longest Duration of Analgesia for Single Injection Peripheral Nerve Blocks in Orthopedic Surgery: A Systematic Review
(2014-12-01)Inadequate pain relief after surgery may delay surgical recovery, decrease patient satisfaction, increase length of stay, increase hospital readmissions, and increase overall health care costs. One way to decrease postoperative ... -
Localization and Characterization of a 7.3-kDa Region of Caldesmon Which Reversibly Inhibits Actomyosin ATPase Activity
(East Carolina University, 1992-08-15)Cleavage of caldesmon with chymotrypsin yields a series of fragments which bind both calmodulin and actin and inhibit the binding of myosin subfragments to actin and the subsequent stimulation of ATPase activity. Several ... -
A Long Helix from the Central Region of Smooth Muscle Caldesmon
(East Carolina University, 1991-07-25)The central region of smooth muscle caldesmon is predicted to form α-helices on the basis of its primary structure. We have isolated a fragment (CT54) that contains this region. The hydrodynamic properties and the electron ... -
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value
(2015)Long noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types. The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal ... -
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
(East Carolina University, 1987-10)We have tested the hypothesis that in vitro exposure of insulin- resistant adipocytes with insulin results in improved insulin action. A primary culture system of adipocytes from obese subjects with ... -
Lower Extremity Strength and Mechanics During Jumping in Women With Patellofemoral Pain
(2009)Context: Lower extremity (LE) weakness might be associated with altered mechanics during weight bearing in subjects with patellofemoral pain syndrome (PFPS). Objective: To analyze LE strength, mechanics, and the association ... -
Lumbee women breast cancer survivors stories: understanding the experience
(East Carolina University, 2009)The purpose of this interpretive study was to understand the experiences of Lumbee women breast cancer survivors from the text of their oral stories about their life events related to surviving breast cancer. Lumbees, the ... -
Lymphocytic hypophysitis.
(East Carolina University, 1994-05)LYMPHOCYTIC HYPOPHYSITIS is an unusual disorder that nearly exclusively affects women; fewer than 50 cases have been reported in the literature. The present case also is unusual because a normal computed tomographic (CT) ... -
Massively multiplayer online role-playing games: problematic use
(East Carolina University, 2013)Massively Multiplayer Online Role Playing Games (MMORPGs) are a form of mass media with potential for behavioral addiction among some users. In past literature on internet addiction, MMORPG users have been included alongside ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
(East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
(East Carolina University, 1995-04)Increased protein kinase C (PKC) activity in malignant breast tissue and positive correlations between PKC activity and expression of a more aggressive phenotype in breast cancer cell lines suggest a role for this signal ... -
Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells
(East Carolina University, 2007-03-06)The mechanisms underlying stem cell acquisition of a cardiac phenotype are unresolved. We studied early events during the acquisition of a cardiac phenotype by a cloned adult liver stem cell line (WB F344) in a cardiac ... -
Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats
(East Carolina University, 2010)The main goal of the current study was to elucidate the molecular mechanisms implicated in central cannabinoid receptor 1 (CB1R)-evoked sympathoexcitation/pressor response. In pursuit of this goal, the candidate first ... -
Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex
(East Carolina University, 2007-11)Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between ...