Browsing Health Sciences Campus by Type"Doctoral Dissertation"
Now showing items 1-20 of 98
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Antigen-specific tolerogenic vaccines inhibit autoimmune disease in a rodent model of multiple sclerosis
(East Carolina University, 2010)Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease directed against myelinated nerves within the central nervous system. Current therapies available to MS patients have low efficacy and are ... -
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ... -
Appraisal of uncertainty while waiting for a kidney transplant
(East Carolina University, 2012)This study tested a middle range nursing theory to better understand the experience of uncertainty in deceased-donor kidney transplant candidates with a goal of identifying ways to improve the care of persons by nurses as ... -
Auditory event-related potentials recorded during passive listening and speech production
(East Carolina University, 2010)What is the role of audition in the process of speech production and speech perception? Specifically, how are speech production and speech perception integrated to facilitate forward flowing speech and communication? ... -
Augmented coronary vascular smooth muscle response to endothelin-1 exacerbates cardiac injury following pulmonary exposure to engineered nanomaterials
(East Carolina University, 2014)Multi-walled carbon nanotubes (MWCNT) and 60-carbon fullerenes (C60) are important engineered nanoparticles (ENP) used across industry. Exposure to ENP potentially promotes cardiovascular detriments. The hypotheses that ... -
The bhuTUV and bhuO genes play vital roles in the ability of Brucella abortus to use heme as an iron source and are regulated in an iron-responsive manner by RirA and Irr
(East Carolina University, 2012)Brucella abortus is a Gram negative intracellular pathogen that causes the zoonotic disease brucellosis. Antibiotic treatment for brucellosis in humans is prolonged and sometimes followed by relapses. Currently, the United ... -
Binaural Interference in Normal Hearing Children
(East Carolina University, 2009)This study was conducted to determine if the phenomenon of binaural interference occurs in normal hearing children. To investigate the possible presence of binaural interference, comparisons of the participants' right, ... -
The Biochemical Characterization Of Neuronal K+ Channel N-Glycans And Their Role In Regulating K+ Channel Function
(East Carolina University, 2009)The Kv3 and Kv1 subfamilies of voltage–gated K+ channels are critical components which contribute to action potential repolarization throughout the central nervous system. Here, it was shown that both absolutely conserved ... -
Breast feeding intention and initiation among rural, low-income Native American and African American adolescent mothers in North Carolina: testing the theory of planned behavior
(East Carolina University, 2014)Abstract Infant feeding practices can greatly impact a child's life with far reaching implications based upon decisions a mother makes for her newborn. Breastfeeding is the preferred method of infant feeding because of ... -
Casual video game play as an augmentation intervention for anxiety: a controlled study
(East Carolina University, 2014)Anxiety is an innate reaction to stress, but when excessive it can develop into a clinical disorder. Traditional anxiety treatments such as pharmaceuticals in combination with psychotherapy have established efficacy in ... -
Categorization in Context for Young and Older Adults
(East Carolina University, 2013)Individuals make sense of the world by grouping items into categories, or clusters of concepts that share certain characteristics. Some research has indicated that older adults may organize concepts differently than young ... -
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
Circadian activation of mast cells mediates the nocturnal response in allergic asthma
(East Carolina University, 2010)Circadian rhythm is a conserved physiological feature of most organisms. Nocturnal symptoms are a common feature of allergic asthma in humans. Patients with nocturnal asthma show circadian variation of their pulmonary ... -
Comparison of tolerance characteristics in the guinea pig following chronic in-vivo exposure to opioid versus cannabinoid receptor agonists
(East Carolina University, 2010)Few studies have compared the nature of tolerance that develops following chronic in vivo opioid treatment with that which develops after chronic cannabinoid exposure in the same tissue and species. Based on similarities ... -
Complementary pain intervention pilot study in the acute hospitalization phase after lower extremity amputation surgery
(East Carolina University, 2014)Complementary pain intervention pilot study in the acute hospitalization phase after lower extremity amputation surgery. The national prevalence of limb loss is approximately 1.7 million people. Leading causes of this ... -
Cultural influence on listener responses to stuttering
(East Carolina University, 2010)Stuttering is a developmental, involuntary, and intermittent fluency disorder. During moments of stuttering, people who stutter demonstrate sudden onsets and offsets of the aberrant struggling behaviors, with primary ... -
[Delta]-catenin: implications in prostate cancer progression
(East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ... -
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ... -
The Distribution Of Regulated Actomyosin States Is Central To Cardiac Muscle Regulation And Disturbance Of This Distribution Leads To Congenital Cardiomyopathies
(East Carolina University, 2009)Hypertrophic and restrictive cardiomyopathies are congenital cardiac diseases that have an incidence of over one in five hundred and may lead to sudden cardiac death. One of the main impediments to directed treatment is ...