Browsing Brody School of Medicine by Author "Farrow, John M. III"
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The Influence of Iron on Pseudomonas aeruginosa Physiology: A regulatory link between iron and quorum sensing
Oglesby, Amanda G.; Farrow, John M. III; Lee, Joon-Hee; Tomaras, Andrew P.; Greenberg, E. Peter; Pesci, Everett C.; Vasil, Michael L. (East Carolina University, 2008-06-06)In iron-replete environments, the Pseudomonas aeruginosa Fur (ferric uptake regulator) protein represses expression of two small regulatory RNAs encoded by prrF1 and prrF2. Here we describe the effects of iron and PrrF ... -
PqsE Functions Independently of PqsR-Pseudomonas Quinolone Signal and Enhances the rhl Quorum-Sensing System
Farrow, John M. III; Sund, Zoe M.; Ellison, Matthew L.; Wade, Dana S.; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2008-11)Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections in immunocompromised individuals. This gram-negative bacterium produces a battery of virulence factors that allow it to ... -
Pseudomonas aeruginosa PqsA Is an Anthranilate-Coenzyme A Ligase
Coleman, James P.; Hudson, L. Lynn; McKnight, Susan L.; Farrow, John M. III; Calfee, M. Worth; Lindsey, Claire A.; Pesci, Everett C. (East Carolina University, 2008-02)Pseudomonas aeruginosa is an opportunistic human pathogen which relies on several intercellular signaling systems for optimum population density-dependent regulation of virulence genes. The Pseudomonas quinolone signal ... -
Transcriptional regulation of 'pqsR', a gene that encodes a regulator of quinolone signal synthesis and virulence in 'Pseudomonas aeruginosa'
Farrow, John M. III (East Carolina University, 2015)The gram-negative bacterium 'Pseudomonas aeruginosa' is an opportunistic pathogen that frequently causes nosocomial infections and serious chronic lung infections in cystic fibrosis patients. During infection 'P. aeruginosa' ... -
The Transcriptional Regulator Np20 Is the Zinc Uptake Regulator in
Ellison, Matthew L.; Farrow, John M. III; Parrish, Whitney; Danell, Allison Stokes; Pesci, Everett C. (2013)Zinc is essential for all bacteria, but excess amounts of the metal can have toxic effects. To address this, bacteria have developed tightly regulated zinc uptake systems, such as the ZnuABC zinc transporter which is ... -
Two Distinct Pathways Supply Anthranilate as a Precursor of the Pseudomonas Quinolone Signal
Farrow, John M. III; Pesci, Everett (East Carolina University, 2007-05)Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control ...