Browsing Brody School of Medicine by Author "Kane, Daniel A."

Now showing items 1-3 of 3

  • Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner 

    Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)
    Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ...

  • Methods for Assessing Mitochondrial Function in Diabetes 

    Perry, Christopher G.R.; Kane, Daniel A.; Lanza, Ian R.; Neufer, P. Darrell (2013-04)
    A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...

  • Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans 

    Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)
    High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ...