Now showing items 1-8 of 8
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
(East Carolina University, 2002-04)
Occludin is an integral membrane protein that is tyrosine phosphorylated when localized at tight junctions. When Ca2 was depleted from the culture medium, occludin tyrosine phosphorylation was diminished from Madin-Darby ...
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
(East Carolina University, 2009-03-10)
Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ...
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
(East Carolina University, 2009-01)
Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ...
Claudins in intestines
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
(East Carolina University, 2009-03-01)
BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ...
A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Background Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral ...