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Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)
Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ...
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)
The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ...
Identification of Factors Associated with the Development and Decay of Heterologous Tolerance to Morphine in the Guinea Pig
(East Carolina University, 2016-05-03)
It is believed that the heterologous tolerance that develops upon chronic exposure to morphine is the result of adaptive changes in the cellular signaling pathways associated with the [mu] opioid receptor. Proposed adaptive ...
Use of monoamine oxidase and redox enzymes in atrial tissue as novel predictors of postoperative atrial fibrillation
(East Carolina University, 2014)
Postoperative atrial fibrillation (POAF) occurs in approximately 30% of cardiac surgery patients. The complication occurs despite advances in surgical procedures. It is associated with increased mortality, morbidity, and ...
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)
Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ...
Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats
(East Carolina University, 2010)
The main goal of the current study was to elucidate the molecular mechanisms implicated in central cannabinoid receptor 1 (CB1R)-evoked sympathoexcitation/pressor response. In pursuit of this goal, the candidate first ...
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)
Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ...
Oxytocin Modulation of Zebra Finch Vocal Development
(East Carolina University, 2010)
Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ...
Comparison of tolerance characteristics in the guinea pig following chronic in-vivo exposure to opioid versus cannabinoid receptor agonists
(East Carolina University, 2010)
Few studies have compared the nature of tolerance that develops following chronic in vivo opioid treatment with that which develops after chronic cannabinoid exposure in the same tissue and species. Based on similarities ...
Molecular Mechanisms of Peripheral N-Methyl-D-Aspartate Mediated Pressor Response
(East Carolina University, 2012)
The primary goal of this study was to characterize the N-Methyl-D-Aspartate (NMDA) receptor within the cardiovascular system and elucidate the molecular mechanisms involved in peripheral NMDA receptor-mediated pressor ...