Author | Ross, Ted | |
Author | Robinson, Harriet | |
Date Accessioned | 2019-11-11T18:38:40Z | |
Date Available | 2019-11-11T18:38:40Z | |
Date of Issue | 2003-03-20 | |
Identifier (Other) | International Publication #WO2003022204A2 | |
Identifier (Other) | US Pat# US28262101P | |
Identifier (URI) | http://hdl.handle.net/10342/7541 | |
Description | The present invention provides a novel vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component, C3d, to enhance the titers of neutralizing antibody. Plasmids were generated that expressed a secreted (s) form of H and the same form fused to three tandem copies of the murine homologue of C3d (sH-3C3d). Analysis of titers of the antibody raised in vaccinated mice indicated that groups vaccinated with the DNA construct expressing sH-3C3d had higher titers of anti-H antibodies compared to serum from mice vaccinated with DNA expressing sH only. In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation. | en_US |
Language | en_US | en_US |
Related URI | https://patents.google.com/patent/WO2003022204A2/en?oq=inassignee:%22East+Carolina%22 | en_US |
Subject | immunization | en_US |
Subject | Vaccine | en_US |
Title | Measles vaccine vectors and methods of use | en_US |
Type | Patent | en_US |