Browsing Biochemistry and Molecular Biology by Submit Date
Now showing items 1-20 of 82
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HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
(East Carolina University, 2022-11-10)ABSTRACT In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ... -
THE DISTINCT ROLES OF TWO eIF4E ISOFORMS AND THEIR COGNATE 4EIPS IN THE GERMLINE OF C. elegans
(East Carolina University, 8/5/2020)Biological information becomes functional at the step of mRNA translation when the protein product is synthesized. Translational regulation of mRNAs is critically important for proper modulation of gene expression in germ ... -
NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
(2017-01-14)A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, ... -
Disruption of pqs synthesis using precursor analogs
(2004-01-08)The present invention concerns methods of detecting bacterial infections as well as methods of treating such infections with compounds such as methyl anthranilate. The detection and treatment of Pseudomonas is particularly ... -
Measles vaccine vectors and methods of use
(2003-03-20)The present invention provides a novel vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component, C3d, to enhance the titers of neutralizing antibody. Plasmids were generated that ... -
Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
(2002-10-17)A method of reducing organ toxicity in a subject being administered a cytotoxic agent comprising concurrently administering with the cytotoxic agent erythropoietin (EPO), the EPO being administered in an amount effective ... -
Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents
(2000-07-13)Composition and formulations comprising a first agent such as folinic acid, pharmaceutically acceptable salts thereof or mixtures thereof, and a second agent(s) such as analgesics, muscle relaxants, mood disorder agents, ... -
Catabolite repression control (crc) gene and pseudomonas virulence
(2002-08-22)A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and ... -
Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds
(2006-07-13)A method of making a compound of Formula (I) comprises reacting a compound of Formula (II) with a compound such as R1OH or R1SH, to produce said compound of Formula (I). Compounds of Formula (I) are useful, among other ... -
Novel autoinducer molecules and uses therefor
(2002-03-07)Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic ... -
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
(2000-02-24)A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, ... -
Relationship of N-glycans to Neuronal Dysfunction
(East Carolina University, 2019-06-07)N-glycosylation is important in regulating protein activity and serves several vital roles contributing to protein folding, protein assembly, stability, and interactions. Changes in branching of N-glycans are linked to ... -
Docosahexaenoic acid-derived metabolites target the B-cell driven immune response in obese mice
(East Carolina University, 2019-06-07)Obesity is associated with an impaired humoral immune response. As B cells mediate the humoral immune response, they are major cellular targets in diet induced obesity models. Several studies have established that B cell ... -
The C-terminus of Troponin T Modulates Calcium Regulation of Actin-Myosin Interactions
(East Carolina University, 2019-05-02)The highly conserved terminal fourteen C-terminal residues of troponin T play a novel role in the regulation of striated muscle contraction. Elimination of the terminal fourteen residues of the C-terminal region of troponin ...