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Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
(East Carolina University, 2010)
The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ...
THE ROLE OF THE ALVEOLAR MACROPHAGE IN CARBON NANOTUBE ELICITED MURINE MODEL OF PULMONARY GRANULOMATOUS INFLAMMATION
(East Carolina University, 2018-11-29)
Pulmonary sarcoidosis is a debilitating inflammatory condition characterized by the presence of granulomatous lesions throughout the lung. Granulomas are a physiological response to inhaled antigens or particulate matter ...
The Functional Roles of pH-sensing G protein-coupled receptors in Intestinal Inflammation
(East Carolina University, 2018-12-06)
The inflammatory microenvironment in inflammatory bowel disease (IBD) is complex, replete with microbial byproducts, complement, leukocytes, and resulting inflammatory cytokines. Parallel to these microenvironmental factors ...
Reproductive Toxicity of Crude oil-Dispersant Mixture in Caenorhabditis elegans
(East Carolina University, 2016-05-05)
As crude oil remains a vital natural resource for the energy need of the world, environmental crude oil spills continue to be a health risk to human beings and ecological systems. During clean-up efforts, surfactant-like ...
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)
Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...
The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response
(East Carolina University, 2010)
Poxviruses are large double-stranded DNA viruses with a broad host range and worldwide distribution. The most infamous poxvirus is Variola virus, the causative agent of smallpox, which caused over 500 million deaths in ...
THE EVOLUTION OFHOX [sic] PARALOG GROUP 2 GENE EXPRESSION AND REGULATION IN THE JAPANESE MEDAKA
(East Carolina University, 2011)
Hox paralog group 2 (PG2) genes are evolutionarily conserved developmental regulatory genes that function to specify rhombomere (r) and pharyngeal arch (PA) identities in animal embryos. Several rounds of whole genome ...
HIGHER-LEVEL SYSTEMATICS OF THE MILLIPEDES (ARTHROPODA: MYRIAPODA: DIPLOPODA) EVALUATED USING TRANSCRIPTOMIC DATA, MITOCHONDRIAL GENOMICS, AND CLASSIFICATION ANALYSES
(East Carolina University, 2012)
Knowledge of deep level phylogenetic relationships within and between many animal groups is currently lacking. Past attempts to reconstruct these ancient evolutionary relationships once relied chiefly on morphological ...
Recruitment of Estuarine-Dependent Alosines to Roanoke River and Albemarle Sound, North Carolina
(East Carolina University, 2012)
The deleterious effects of dams on alosine populations are widely documented in many rivers along the Atlantic coast. Alterations to the natural hydrologic regime can disrupt spawning, egg dispersal, and recruitment of ...
The serine protease from the venom of polistes dominulus contains allergenic epitopes
(East Carolina University, 2010)
The protection introduced by immunotherapy to patients with allergies to paper wasps may be partial depending on the sensitizing species. Partial cross-reactivity between major paper wasp groups may be the reason for ...