2024-03-28T16:26:51Zhttps://thescholarship.ecu.edu/oai/requestoai:TheScholarship.intra.ecu.edu:10342/33302022-12-13T19:15:44Zcom_10342_74com_10342_73col_10342_92
Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age
Kuban, Karl C. K.
Allred, Elizabeth N.
O'Shea, T. Michael
Paneth, Nigel
Pagano, Marcello
Dammann, Olaf
Leviton, Alan
Plessis, Adre Du
Westra, Sjirk J.
Miller, Cindy R.
Bassan, Haim
Krishnamoorthy, Kalpathy
Junewick, Joseph
Olomu, Nicholas
Romano, Elaine
Seibert, Joanna
Engelke, Stephen C.
Karna, Padmani
Batton, Daniel
O'Connor, Sunila E.
Keller, Cecelia E.
Cerebral palsy
Estremely low gestational age
Cranial ultrasound
Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. Originally published Journal of Child Neurology, Vol. 24, No. 1, Jan 2009
2011-04-15T15:44:21Z
2011-05-17T00:38:33Z
2011-04-15T15:44:21Z
2011-05-17T00:38:33Z
2009-01
Article
Journal of Child Neurology; 24:1 p. 63-72
http://hdl.handle.net/10342/3330
PMC2814246
10.1177/0883073808321048
en_US
http://jcn.sagepub.com/content/24/1/63.long
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
East Carolina University