2024-03-29T02:37:11Zhttps://thescholarship.ecu.edu/oai/requestoai:TheScholarship.intra.ecu.edu:10342/115632022-10-21T07:15:58Zcom_10342_74com_10342_73col_10342_97
Takeda, Kotaro
Geisinger, Kim R.
Rebellato, Lorita M.
Mittenzwei, Rhonda
Datto, Michael B.
2022-10-20T15:38:22Z
2022-10-20T15:38:22Z
2021
0041-1345
http://hdl.handle.net/10342/11563
10.1016/j.transproceed.2021.03.002
en_US
Cancer transmission
transplant recipient
Neuroendocrine Carcinoma
Donor-Derived Neuroendocrine Carcinoma Transmission to Two Kidney Transplant Recipients Demonstrated by Short Tandem Repeat Analysis: A Case Report
Article
oai:TheScholarship.intra.ecu.edu:10342/107432022-06-30T07:15:54Zcom_10342_74com_10342_73col_10342_97
Stalls, J. Stephen
Mohamed, Anas
Hassan, Masood
Geisinger, Kim
Kanungo, Anuradha
Vora, Moiz
Patel, Anokhi
Weil, Andrew
2022-06-29T15:57:57Z
2022-06-29T15:57:57Z
2021-06
2214-3300
http://hdl.handle.net/10342/10743
10.1016/j.ehpc.2021.200536
en
Primary adrenal lymphoma
Diffuse large B cell lymphoma
Melanoma
Primary Bilateral Adrenal Lymphoma Masquerading as a Metastatic Melanoma: An Unusual Presentation of a Rare Disease
Article
oai:TheScholarship.intra.ecu.edu:10342/75462021-03-03T21:24:50Zcom_10342_74com_10342_73col_10342_97
Van Dross, Rukiyah
2019-12-02T15:11:18Z
2019-12-02T15:11:18Z
2017-09-08
International Publication # WO2017151836A1
http://hdl.handle.net/10342/7546
Provided is a method of preventing and/or treating a skin disorder and/or an oral disorder including administering to a subject in need thereof an effective amount of a compound of formula (I) or a prodrug or derivative thereof, and salts thereof.
en_US
endoplasmic reticulum
prodrug
dermatology
J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
Patent
oai:TheScholarship.intra.ecu.edu:10342/107152022-06-23T07:16:04Zcom_10342_74com_10342_73col_10342_97
Anderson, Matthew P.
Quinton, Reade
Kelly, Karen
Falzon, Andrew
Halladay, Alycia
Schumann, Cynthia M.
Hof, Patrick R.
Tamminga, Carol A.
Amaral, David G.
2022-06-22T15:42:59Z
2022-06-22T15:42:59Z
2021-04
0003-9985
10.5858/ arpa.2020-0164-RA
http://hdl.handle.net/10342/10715
en
Autism Spectrum Disorder (ASD)
treatment
understanding
Autism BrainNet: A Collaboration between Medical Examiners, Pathologists, Researchers, and Families to Advance the Understanding and Treatment of Autism Spectrum Disorder
Article
oai:TheScholarship.intra.ecu.edu:10342/117082022-12-14T15:42:49Zcom_10342_74com_10342_73col_10342_97
Fallon, John T.
Hernandez, Patricia V.
Razzano, Dana
Riddle, Nicole D.
Islam, Humayun K.
Mirza, Kamran M.
Pattarkine, Rugved
Platero, Tania
Hermelin, Daniela
Adem, Patricia V.
Booth, Adam L.
Nachinga, Eunice Mbela
Reddy, Kalpana S.
Mares, Angelica
Lento, Patrick A.
2022-11-07T14:31:24Z
2022-11-07T14:31:24Z
2022-04
0003-9985
http://hdl.handle.net/10342/11708
10.5858/arpa.2020-0834-OA
en_US
Pathology
Career Recruitment Strategies
Medical Students
Measuring the Efficacy of Pathology Career Recruitment Strategies in US Medical Students
Article
oai:TheScholarship.intra.ecu.edu:10342/115612022-10-21T07:15:57Zcom_10342_74com_10342_73col_10342_97
Geisinger, Kim R.
Risley, Carolann
Stewart, Mary W.
Hiser, Laree M.
Morgan, Jody C.
Owens, Kenyata J.
Ayyalasomayajula, Krishna
Rives, Rhonda M.
Jannela, Ashish
Grunes, Dianne E.
Zhang, Lei
Schiffman, Mark
Wentzensen, Nicolas
Clarke, Megan A.
2022-10-20T13:59:29Z
2022-10-20T13:59:29Z
2021
0091-7435
http://hdl.handle.net/10342/11561
10.1016/j.ypmed.2021.106740
en_US
Cervical cancer
Disparities
Race
STRIDES - STudying Risk to Improve DisparitiES in Cervical Cancer in Mississippi – Design and Baseline Results of a Statewide Cohort Study
Article
oai:TheScholarship.intra.ecu.edu:10342/123542023-02-21T08:16:20Zcom_10342_74com_10342_73col_10342_97
Geradts, Joseph
Rebbeck, Clare A.
et al
2023-02-20T19:16:49Z
2023-02-20T19:16:49Z
2022-06-13
2041-1723
http://hdl.handle.net/10342/12354
10.1038/s41467-022-30573-4
en_US
Ductal carcinoma in situ (DCIS)
biomarkers
breast cancer
Gene Expression Signatures of Individual Ductal Carcinoma in Situ Lesions Identify Processes and Biomarkers Associated with Progression Towards Invasive Ductal Carcinoma
Article
oai:TheScholarship.intra.ecu.edu:10342/117092022-11-08T08:16:24Zcom_10342_74com_10342_73col_10342_97
Mohamed, Anas
Kousar, Aisha
Geradts, Joseph
Wong, Jan
Vohra, Nasreen
Muzaffar, Mahvish
2022-11-07T14:37:08Z
2022-11-07T14:37:08Z
2022-02-04
0003-9985
http://hdl.handle.net/10342/11709
10.5858/arpa.2021-0367-OA
en_US
Oncotype DX Recurrence Score (RS)
chemotherapy benefit
Surrogate Models
Pathobiologic Stratification of Oncotype DX Recurrence Scores and Comparative Validation of 3 Surrogate Models
Article
oai:TheScholarship.intra.ecu.edu:10342/115192022-10-15T07:16:01Zcom_10342_74com_10342_73col_10342_97
Smith, Ralph
Arthur, Justin
Lehman, John M.
Hainley, Lydia E.
Hughson, Martina S.
Narendran, Amithi
Hayner-Buchan, Alida
Conti, David J.
Friedrich, Thomas D.
2022-10-14T15:22:26Z
2022-10-14T15:22:26Z
2021-07-13
1999-4915
http://hdl.handle.net/10342/11519
10.3390/v13071353
en_US
polyomavirus
DNA damage response
antiviral
Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection
Article
oai:TheScholarship.intra.ecu.edu:10342/51832021-03-03T20:59:56Zcom_10342_74com_10342_73col_10342_97
Read, Marjorie S.
Bode, Arthur P.
Summarial, Louis J.
2016-02-05T17:41:49Z
2016-02-05T17:41:49Z
1999-04-06
U.S. Patent No. 5,891,393
http://hdl.handle.net/10342/5183
A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being contaminated with microorganisms. The platelets are then contacted to a fixative for a time sufficient to fix the platelets. After fixing, the platelets are preferably washed and dried to produce fixed-dried platelets. The step of contacting the platelets to a fixative is carried out for a time sufficient to kill some or all the of the contaminating microorganisms.
Method for the microbial decontamination of blood platelets
Patent
oai:TheScholarship.intra.ecu.edu:10342/57472021-03-03T21:12:00Zcom_10342_74com_10342_73col_10342_97
Maclary, Emily
Buttigieg, Emily
Hinten, Michael
Gayen, Srimonta
Harris, Clair
Sarkar, Mrinal Kumar
Purushothaman, Sonya
Kalantry, Sundeep
2016-06-27T15:32:24Z
2016-06-27T15:32:24Z
2014-06
Nature communications; 5: p. 4209-4209
2041-1723
http://hdl.handle.net/10342/5747
pmc4086345
10.1038/ncomms5209
Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome. The pre-programmed fate of the X-chromosomes is thought to be controlled in cis by the parent-of-origin-specific expression of two long non-coding RNAs, Tsix and Xist, in mice. Exclusive expression of Tsix from the maternal–X has implicated it as the instrument through which the maternal germline prevents inactivation of the maternal–X in the offspring. Here, we show that Tsix is dispensable for inhibiting Xist and X-inactivation in the early embryo and in cultured stem cells of extra-embryonic lineages. Tsix is instead required to prevent Xist expression as trophectodermal progenitor cells differentiate. Despite induction of wild-type Xist RNA and accumulation of histone H3-K27me3, many Tsix-mutant X-chromosomes fail to undergo ectopic X-inactivation. We propose a novel model of lncRNA function in imprinted X-inactivation that may also apply to other genomically imprinted loci.
Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation
Article
oai:TheScholarship.intra.ecu.edu:10342/57452021-03-03T21:11:57Zcom_10342_74com_10342_73col_10342_97
Byrne, Susan
Jansen, Lara
U-King-Im, Jean-Marie
Siddiqui, Ata
Lidov, Hart G. W.
Bodi, Istvan
Smith, Luke
Mein, Rachael
Cullup, Thomas
Dionisi-Vici, Carlo
Al-Gazali, Lihadh
Al-Owain, Mohammed
Bruwer, Zandre
Al Thihli, Khalid
El-Garhy, Rana
Flanigan, Kevin M.
Manickam, Kandamurugu
Zmuda, Erik
Banks, Wesley
Gershoni-Baruch, Ruth
Mandel, Hanna
Dagan, Efrat
Raas-Rothschild, Annick
Barash, Hila
Filloux, Francis
Creel, Donnell
Harris, Michael
Hamosh, Ada
Kölker, Stefan
Ebrahimi-Fakhari, Darius
Hoffmann, Georg F.
Manchester, David
Boyer, Philip J.
Manzur, Adnan Y.
Lourenco, Charles Marques
Pilz, Daniela T.
Kamath, Arveen
Prabhakar, Prab
Rao, Vamshi K.
Rogers, R. Curtis
Ryan, Monique M.
Brown, Natasha J.
McLean, Catriona A.
Said, Edith
Schara, Ulrike
Stein, Anja
Sewry, Caroline
Travan, Laura
Wijburg, Frits A.
Zenker, Martin
Mohammed, Shehla
Fanto, Manolis
Gautel, Mathias
Jungbluth, Heinz
2016-06-27T15:28:50Z
2016-06-27T15:28:50Z
2016-03
Brain; 139:3 p. 765-781
2575113
http://hdl.handle.net/10342/5745
pmc4766378
10.1093/brain/awv393
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and neuropathological features of 50 children from 30 families, as well as the neuronal phenotype of EPG5 knock-down in Drosophila melanogaster. We identified 39 different EPG5 mutations, most of them truncating and predicted to result in reduced EPG5 protein. Most mutations were private, but three recurrent mutations (p.Met2242Cysfs*5, p.Arg417*, and p.Gln336Arg) indicated possible founder effects. Presentation was mainly neonatal, with marked hypotonia and feeding difficulties. In addition to the five principal features (callosal agenesis, cataracts, hypopigmentation, cardiomyopathy, and immune dysfunction), we identified three equally consistent features (profound developmental delay, progressive microcephaly, and failure to thrive). The manifestation of all eight of these features has a specificity of 97%, and a sensitivity of 89% for the presence of an EPG5 mutation and will allow informed decisions about genetic testing. Clinical progression was relentless and many children died in infancy. Survival analysis demonstrated a median survival time of 24 months (95% confidence interval 0–49 months), with only a 10th of patients surviving to 5 years of age. Survival outcomes were significantly better in patients with compound heterozygous mutations (P = 0.046), as well as in patients with the recurrent p.Gln336Arg mutation. Acquired microcephaly and regression of skills in long-term survivors suggests a neurodegenerative component superimposed on the principal neurodevelopmental defect. Two-thirds of patients had a severe seizure disorder, placing EPG5 within the rapidly expanding group of genes associated with early-onset epileptic encephalopathies. Consistent neuroradiological features comprised structural abnormalities, in particular callosal agenesis and pontine hypoplasia, delayed myelination and, less frequently, thalamic signal intensity changes evolving over time. Typical muscle biopsy features included fibre size variability, central/internal nuclei, abnormal glycogen storage, presence of autophagic vacuoles and secondary mitochondrial abnormalities. Nerve biopsy performed in one case revealed subtotal absence of myelinated axons. Post-mortem examinations in three patients confirmed neurodevelopmental and neurodegenerative features and multisystem involvement. Finally, downregulation of epg5 (CG14299) in Drosophila resulted in autophagic abnormalities and progressive neurodegeneration. We conclude that EPG5-related Vici syndrome defines a novel group of neurodevelopmental disorders that should be considered in patients with suggestive features in whom mitochondrial, glycogen, or lysosomal storage disorders have been excluded. Neurological progression over time indicates an intriguing link between neurodevelopment and neurodegeneration, also supported by neurodegenerative features in epg5-deficient Drosophila, and recent implication of other autophagy regulators in late-onset neurodegenerative disease.
EPG5
ectopic P granules autophagy protein 5
Vici syndrome
neurodevelopment
neurodegeneration
callosal agenesis
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
Article
oai:TheScholarship.intra.ecu.edu:10342/108962022-07-21T08:32:56Zcom_10342_74com_10342_73col_10342_97
Mohamed, Anas
Younes, Ahmed I.
Stall, Stephen
Kousar, Aisha
Li, Tian
2022-07-20T14:04:38Z
2022-07-20T14:04:38Z
2021
2050-0904
http://hdl.handle.net/10342/10896
10.1002/ccr3.4449
en_US
ductal carcinoma in situ
mammography
radiation
An Unusual Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma on Mammography: Case Report
Article
oai:TheScholarship.intra.ecu.edu:10342/118102022-12-12T17:48:25Zcom_10342_74com_10342_73col_10342_97
Dal Zotto, Valeria L.
Wilhite, Annelise M.
2022-12-02T20:19:19Z
2022-12-02T20:19:19Z
2022-03-21
2352-5789
http://hdl.handle.net/10342/11810
10.1016/j.gore.2022.100962
en_US
Perivascular epithelioid cell tumor (PEComa)
pregnancy
treatment
Perivascular Epithelioid Cell Tumor (PEComa) of the Uterus: Challenges of Pregnancy in Determining Prognosis and Optimal Treatment
Article
oai:TheScholarship.intra.ecu.edu:10342/52032021-03-03T20:58:49Zcom_10342_74com_10342_73col_10342_97
Read, Marjorie S.
Reddick, Robert L.
Bode, Arthur P.
2016-02-10T17:52:02Z
2016-02-10T17:52:02Z
1999-11-30
U.S. Patent No. 5,994,315
http://hdl.handle.net/10342/5203
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
Pharmaceutically acceptable fixed-dried human blood platelets
Patent
oai:TheScholarship.intra.ecu.edu:10342/33062021-03-03T20:55:16Zcom_10342_74com_10342_73col_10342_97
Magner, James A.
West, R. Lee
2011-03-29T19:38:34Z
2011-03-29T19:38:34Z
1994-05
Western Journal of Medicine; 160:5 p. 462-464
http://hdl.handle.net/10342/3306
PMC1022499
LYMPHOCYTIC HYPOPHYSITIS is an unusual disorder that nearly exclusively affects women; fewer than 50 cases have been reported in the literature. The present case also is unusual because a normal computed tomographic (CT) scan had been obtained of the sella shortly before the development of a large pituitary mass due to lymphocytic hypophysitis. Lymphocytes were characterized using immunoperoxidase stains. A probably unrelated malabsorption syndrome later complicated her hormone replacement therapy. Originally published Western Journal of Medicine, Vol. 160, No. 5, May 1994
en_US
Lymphocytic hypophysitis
CT scan
Pituitary mass
Lymphocytic hypophysitis.
Article
oai:TheScholarship.intra.ecu.edu:10342/75242021-03-03T21:24:22Zcom_10342_74com_10342_73col_10342_97
Rastatter, Michael
Kalinowski, Joseph
Stuart, Andrew
2019-11-05T21:21:32Z
2019-11-05T21:21:32Z
2004-04-22
International Publication # WO2004032816A3
http://hdl.handle.net/10342/7524
A device (10) and method for treating subjects having non-stuttering pathologies or disorders using frequency altered feedback including positioning a ear-supported device (10E) for receiving auditory signals associated with a subject's speech in close proximity to at least one ear of an individual, the device (10) being adapted to be in communication with at least one of the ear canals of the individual, receiving at the device (10) an audio signal associated with the subject's speech; generating from the device (10) a frequency altered auditory feedback signal having an associated frequency shift between about +/- 2 octaves relative to the received audio signal; and transmitting the frequency altered auditory feedback signal to at least one ear canal of the subject.
en_US
hearing
speech
auditory
pathology
Frequency altered feedback for treating non-stuttering pathologies
Patent
oai:TheScholarship.intra.ecu.edu:10342/107872022-07-19T07:16:04Zcom_10342_74com_10342_73col_10342_97
Devi, Gayathri R.
Finetti, Pascal
Morse, Michael A.
Lee, Seayoung
de Nonneville, Alexandre
Van Laere, Steven
Troy, Jesse
Geradts, Joseph
McCall, Shannon
Bertucci, Francois
2022-07-18T18:15:11Z
2022-07-18T18:15:11Z
2021-06-04
2072-6694
http://hdl.handle.net/10342/10787
10.3390/cancers13112807
en_US
anthracycline
apoptosis
cell death
Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) in Breast Cancer Is Associated with Shorter Survival and Resistance to Chemotherapy
Article
oai:TheScholarship.intra.ecu.edu:10342/58312021-03-03T21:12:04Zcom_10342_74com_10342_73col_10342_97
Gilden, Don
White, Teresa
Khmeleva, Nelly
Boyer, Philip J.
Nagel, Maria A.
2016-07-28T17:20:30Z
2016-07-28T17:20:30Z
2016-03
Neurology® Neuroimmunology & Neuroinflammation; 3:2 p. 1-3
2332-7812
http://hdl.handle.net/10342/5831
pmc4794807
10.1212/NXI.0000000000000216
Objective:
Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
Methods:
Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were examined by immunohistochemistry for presence and distribution of VZV antigen and by ultrastructural examination for virions. Adjacent regions were examined by hematoxylin & eosin staining. VZV antigen–positive slides were analyzed by PCR for VZV DNA.
Results:
VZV antigen was found in 61/82 (74%) GCA-positive TAs compared with 1/13 (8%) normal TAs (p < 0.0001, relative risk 9.67, 95% confidence interval 1.46, 63.69). Most GCA-positive TAs contained viral antigen in skip areas. VZV antigen was present mostly in adventitia, followed by media and intima. VZV antigen was found in 12/32 (38%) skeletal muscles adjacent to VZV antigen–positive TAs. Despite formalin fixation, VZV DNA was detected in 18/45 (40%) GCA-positive VZV antigen–positive TAs, in 6/10 (60%) VZV antigen–positive skeletal muscles, and in one VZV antigen–positive normal TA. Varicella-zoster virions were found in a GCA-positive TA. In sections adjacent to those containing VZV, GCA pathology was seen in 89% of GCA-positive TAs but in none of 18 adjacent sections from normal TAs.
Conclusions:
Most GCA-positive TAs contained VZV in skip areas that correlated with adjacent GCA pathology, supporting the hypothesis that VZV triggers GCA immunopathology. Antiviral treatment may confer additional benefit to patients with GCA treated with corticosteroids, although the optimal antiviral regimen remains to be determined.
VZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100+ temporal arteries
Article
oai:TheScholarship.intra.ecu.edu:10342/116822022-11-03T07:15:53Zcom_10342_74com_10342_73col_10342_97
Geradts, Joseph
Carmichael, Iain
Calhoun, Benjamin C.
Hoadley, Katherine A.
Troester, Melissa A.
Couture, Heather D.
Olsson, Linnea
Perou, Charles M.
Niethammer, Marc
Hannig, Jan
Marron, J.S.
2022-11-02T14:39:45Z
2022-11-02T14:39:45Z
2021
1932-6157
http://hdl.handle.net/10342/11682
10.1214/20-aoas1433
en_US
Multi-view data
dimensionality reduction
image analysis
Joint and Individual Analysis of Breast Cancer Histologic Images and Genomic Covariates
Article
oai:TheScholarship.intra.ecu.edu:10342/114042022-10-04T07:16:04Zcom_10342_74com_10342_73col_10342_97
Boyer, Philip J.
Bubak, Andrew N.
Hassell, James E. Jr.
Nagel, Maria A.
2022-10-03T18:06:18Z
2022-10-03T18:06:18Z
2021-03-15
0022-510X
http://hdl.handle.net/10342/11404
10.1016/j.jns.2021.117315
en_US
Varicella zoster virus
Cerebral amyloid angiopathy
Vasculopathy
Detection of Varicella Zoster Virus Antigen and DNA in Two Cases of Cerebral Amyloid Angiopathy
Article
oai:TheScholarship.intra.ecu.edu:10342/110712022-09-10T07:15:56Zcom_10342_74com_10342_73col_10342_97
Dal Zotto, Valeria L.
Lee, Kevin J.
Wright, Griffin
Bryant, Hannah
Wiggins, Leigh Ann
Schuler, Michele
Malozzi, Christopher
Cohen, Michael V.
Gassman, Natalie R.
2022-09-09T12:54:01Z
2022-09-09T12:54:01Z
2021-07-12
1422-0067
http://hdl.handle.net/10342/11071
10.3390/ijms22147439
en_US
antioxidant
oncology
cardiology
Cytoprotective Effect of Vitamin D on Doxorubicin-Induced Cardiac Toxicity in Triple Negative Breast Cancer
Article
oai:TheScholarship.intra.ecu.edu:10342/57482021-03-03T21:12:03Zcom_10342_74com_10342_73col_10342_97
Sun, Yuping
Hewan-Lowe, Karlene
Wu, Qiang
Yu, Jiang
Guo, Zhiqiu
Han, Yali
Fan, Yujiang
Qin, Xianfang
Xu, Ping
Bolatihan, Janati
Hoshaerbai, Mayinuer
Yuan, Luping
Hong, Heng
2016-06-27T15:33:45Z
2016-06-27T15:33:45Z
2011-11
The Open AIDS Journal; 5: p. 96-101
1874-6136
http://hdl.handle.net/10342/5748
pmc3242400
10.2174/1874613601105010096
Objective:
The number of people infected with human immunodeficiency virus (HIV) in China has increased in recent years. HIV screening for pregnant women was performed in a remote area in Xinjiang, as an effort to promote universal HIV screening in pregnant women and to help prevention of mother-to-child transmission.
Methods:
Pregnant women in Burqin and Jeminay Counties in Xinjiang were offered free voluntary HIV screening. Local mid-level medical workers were trained to use Determine® HIV-1/2 kit for HIV screening. All the tested pregnant women signed a consent form, received HIV education material, and participated in an HIV knowledge survey.
Results:
All the 890 pregnant women receiving HIV test had negative result. Among these women, 67.6% were Kazakh and 40.9% were farmers. Survey of HIV knowledge showed that these women's awareness about mother-to-child transmission was limited. The levels of HIV knowledge were related with ethnic background, age, education and profession of the pregnant women.
Conclusion:
The results suggested that HIV infection had not become a significant problem among the pregnant women in this remote area of Xinjiang, but continued efforts to improve the awareness of HIV, especially the knowledge about mother-to-child transmission of HIV, in pregnant women were needed.
Universal HIV screen
pregnant women
mother-to-child transmission
HIV Screening and Awareness Survey for Pregnant Women in a Remote Area in Xinjiang Uyghur Autonomous Region of China
Article
oai:TheScholarship.intra.ecu.edu:10342/30412021-03-03T20:54:14Zcom_10342_74com_10342_73col_10342_97
Tsuji, Shoutaro
Yamashita, Makiko
Hoffman, Donald R.
Nishiyama, Akihito
Shinohara, Tsutomu
Ohtsu, Takashi
Shibata, Yoshimi
2011-01-20T16:43:49Z
2011-01-20T16:43:49Z
2009-05
Glycobiology; 19:5 p. 518-526
http://hdl.handle.net/10342/3041
PMC2667160
10.1093/glycob/cwp013
Intelectin is an extracellular animal lectin found in chordata. Although human and mouse intelectin-1 recognize galactofuranosyl residues included in cell walls of various microorganisms, the physiological function of mammalian intelectin had been unclear. In this study, we found that human intelectin-1 was a serum protein and bound to Mycobacterium bovis bacillus Calmette-Gu´erin (BCG). Human intelectin-1-binding to BCG was inhibited by Ca2+- depletion, galactofuranosyl disaccharide, ribose, or xylose, and was dependent on the trimeric structure of human intelectin-1. Although monomeric, mouse intelectin-1 bound to BCG, with its C-terminal region contributing to efficient binding. Human intelectin-1-transfected cells not
only secreted intelectin-1 into culture supernatant but also expressed intelectin-1 on the cell surface. The cell surface intelectin-1 was not a glycosylphosphatidylinositolanchored membrane protein. Intelectin-1-transfected cells captured BCG more than untransfected cells, and the BCG adherence was inhibited by an inhibitory saccharide of intelectin-1. Intelectin-1-preincubated cells took up BCG more than untreated cells, but the adhesion of intelectin-1- bound BCG was the same as that of untreated BCG. Mouse macrophages phagocytosedBCGmore efficiently in medium containing mouse intelectin-1 than in control medium. These results indicate that intelectin is a host defense lectin that assists phagocytic clearance of microorganisms. Originally published Glycobiology, Vol. 19, No. 5, May 2009
en_US
Galactofuranose
Innate immunity
Intelectin
Lectin
Mycobacteria
Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guérin by intelectin-1deposited on cell surfaces
Article
oai:TheScholarship.intra.ecu.edu:10342/57442021-03-03T21:12:13Zcom_10342_74com_10342_73col_10342_97
Sun, Ping
Juskevicius, Ridas
2016-06-27T15:26:25Z
2016-06-27T15:26:25Z
2012
Diagnostic Pathology; 7: p. 107-107
1746-1596
http://hdl.handle.net/10342/5744
pmc3488513
10.1186/1746-1596-7-107
Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell lymphocytosis with circulating hallmark binucleated lymphocytes and elevated polyclonal serum IgM. Most patients have benign clinical course on long-term follow-up. Some pathologic features of PPBL may resemble malignant lymphoma, including morphology as well as frequent cytogenetic and molecular abnormalities. Significant symptomatic splenomegaly requiring splenectomy is very unusual for this disorder; therefore there is a lack of descriptions of the morphologic features of the spleen in the literature. We present here one of the first detailed descriptions of the morphologic and immunohistochemical features of the spleen from a young female with PPBL who developed massive splenomegaly during 6-year follow up. Splenectomy was performed for symptomatic relief and suspicion of malignant process. The morphological and immunohistochemical features of the spleen closely mimicked involvement by B-cell lymphoma, however there was no monotypic surface light chain restriction seen by flow cytometry and no clonal rearrangement of IgH gene was detected by molecular analysis. Evaluating a splenectomy sample in cases like this may present a diagnostic challenge to pathologists. Therefore, correlation with B cell clonality studies (by flow cytometry and molecular analysis), clinical findings and peripheral blood morphology searching for characteristic binucleated lymphocytes is essential to avoid misdiagnosing this benign process as B-cell lymphoma. We also present here a literature review on pathogenesis of PPBL.
Persistent polyclonal B cell lymphocytosis
Splenomegaly
Lymphoma
Binucleated lymphocytes
Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma
Article
oai:TheScholarship.intra.ecu.edu:10342/51792021-03-03T20:58:56Zcom_10342_74com_10342_73col_10342_97
Fischer, Thomas
Read, Marjorie
Bode, Arthur P.
Nichols, Timothy
2016-02-05T17:32:01Z
2016-02-05T17:32:01Z
2008-04-15
U.S. Patent No. 7,358,039
http://hdl.handle.net/10342/5179
Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
Fixed-dried red blood cells
Patent
oai:TheScholarship.intra.ecu.edu:10342/108952022-07-21T08:32:56Zcom_10342_74com_10342_73col_10342_97
Younes, Ahmed I.
Mohamed, Anas
Rizvi, Areeba H.
Prenshaw, Karyn
2022-07-20T14:03:47Z
2022-07-20T14:03:47Z
2021
2050-0904
http://hdl.handle.net/10342/10895
10.1002/ccr3.4495
en_US
antrum
melanoma
mucosal
Primary Malignant Melanoma of the Gastric Antrum: A Case Report
Article
oai:TheScholarship.intra.ecu.edu:10342/112672022-09-20T07:16:01Zcom_10342_74com_10342_73col_10342_97
Donthi, Deepak
Prenshaw, Karyn
Nenow, Joseph
Samia, Arthur
Papalas, John
Phillips, Charles
2022-09-19T16:56:47Z
2022-09-19T16:56:47Z
2021
2050-313X
http://hdl.handle.net/10342/11267
10.1177/2050313x211023655
en_US
Dermatology
pathology
Morbihan
Morbihan Disease: A Diagnostic Dilemma: Two Cases with Successful Resolution
Article
oai:TheScholarship.intra.ecu.edu:10342/75442019-12-02T15:10:56Zcom_10342_74com_10342_73col_10342_97
2019-12-02T15:10:55Z
2019-12-02T15:10:55Z
2015-10-06
US Pat# US9149666B2
http://hdl.handle.net/10342/7544
The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic conditions.
en_US
Fast acting SNARE-cleaving enzymes
Patent
oai:TheScholarship.intra.ecu.edu:10342/51782021-03-03T21:00:45Zcom_10342_74com_10342_73col_10342_97
Fischer, Thomas
Read, Marjorie
Bode, Arthur P.
Nichols, Timothy
2016-02-05T17:31:05Z
2016-02-05T17:31:05Z
2005-04-26
U.S. Patent No. 6,884,573
http://hdl.handle.net/10342/5178
Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
Fixed dried red blood cells and method of use
Patent
oai:TheScholarship.intra.ecu.edu:10342/51822021-03-03T20:59:58Zcom_10342_74com_10342_73col_10342_97
Read, Marjorie S.
Reddick, Robert L.
Bode, Arthur P.
2016-02-05T17:40:38Z
2016-02-05T17:40:38Z
1999-05-11
U.S. Patent No. 5,902,608
http://hdl.handle.net/10342/5182
Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.
Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets
Patent
oai:TheScholarship.intra.ecu.edu:10342/75452021-03-03T21:24:49Zcom_10342_74com_10342_73col_10342_97
Fletcher, Paul
Fletcher, Maryann
Martin, Brian
2019-12-02T15:11:10Z
2019-12-02T15:11:10Z
2015-10-06
US Pat# US9149666B2
http://hdl.handle.net/10342/7545
The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic conditions.
en_US
poison
enzymes
treatment
Fast acting SNARE-cleaving enzymes
Patent
oai:TheScholarship.intra.ecu.edu:10342/57462021-03-03T21:11:58Zcom_10342_74com_10342_73col_10342_97
Hong, Heng
Mel, Lin
Taylor, Jonathan
Wu, Qiang
Reeves, Hugh
2016-06-27T15:30:31Z
2016-06-27T15:30:31Z
2012
Diagnostic Pathology; 7: p. 24-24
1746-1596
http://hdl.handle.net/10342/5746
pmc3313848
10.1186/1746-1596-7-24
Background
Robotic-assisted laparoscopic prostatectomy (RALP) has greatly changed clinical management of prostate cancer. It is important for pathologists and urologists to compare RALP with conventional open radical retropubic prostatectomy (RRP), and evaluate their effects on surgical pathology specimens.
Methods
We retrospectively reviewed and statistically analyzed 262 consecutive RALP (n = 182) and RRP (n = 80) procedures performed in our institution from 2007 to 2010. From these, 49 RALP and 33 RRP cases were randomly selected for additional microscopic examination to analyze the degree of capsular incision and the amount of residual prostate surface adipose tissue.
Results
Positive surgical margins were present in 28.6% RALP and 57.5% RRP cases, a statistically significant difference. In patients with stage T2c tumors, which represent 61.2% RALP and 63.8% RRP patients, the positive surgical margin rate was 24.1% in the RALP group and 58.8% in the RRP group (statistically significant difference). For other pathologic stages, the differences in positive margins between RALP and RRP groups were not statistically significant. The incidence of positive surgical margins after RALP was related to higher tumor stage, higher Gleason score, higher tumor volume and lower prostate weight, but was not related to the surgeons performing the procedure. When compared with RRP, RALP also caused less severe prostatic capsular incision and maintained larger amounts of residual surface adipose tissue in prostatectomy specimens.
Conclusions
In this study RALP showed a statistically significant lower positive surgical margin rate than RRP. Analysis of capsular incision and amount of prostatic surface residual adipose tissue suggested that RALP caused less prostatic capsular damage than RRP.
Robotic-assisted laparoscopic prostatectomy
Radical retropubic prostatectomy,
Prostate cancer
Positive surgical margin
Capsular incision
Effects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimens
Article
oai:TheScholarship.intra.ecu.edu:10342/51802021-03-03T20:59:53Zcom_10342_74com_10342_73col_10342_97
Bode, Arthur P.
Heaton, William A.L.
Holme, Stein
Miller, David T.
2016-02-05T17:34:18Z
2016-02-05T17:34:18Z
1991-02-19
U.S. Patent No. 4,994,367
http://hdl.handle.net/10342/5180
A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inhibitor is Theophylline, a preferred plasmin inhibitor is Aprotinin, and a preferred thrombin inhibitor is N-(2-naphthylsulfonylglycyl)-D,L-amidinophenylalaninpiperidide.
Extended shelf life platelet preparations and process for preparing the same
Patent
oai:TheScholarship.intra.ecu.edu:10342/57422021-03-03T21:12:12Zcom_10342_74com_10342_73col_10342_97
Boyd, Jonathan D
Juskevicius, Ridas
2016-06-27T15:23:21Z
2016-06-27T15:23:21Z
2012
Thyroid Research; 5: p. 5-5
1756-6614
http://hdl.handle.net/10342/5742
pmc3411457
10.1186/1756-6614-5-5
Background
Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism. A small percentage of these cases however represent neoplastic/malignant diseases which require further treatment.
Cases
12 year old boy with one year history of refractory Graves disease was found to have an anterior mediastinal mass and underwent curative thyroidectomy for sustained hyperthyroidism. Cervical lymphadenopathy was detected during the procedure and biopsy was obtained. A 23 year old woman who presented with a one month history of hyperthyroid symptoms, was diagnosed with Graves disease and also was found to have an anterior mediastinal mass on imaging. Biopsy of the anterior mediastinal mass was obtained and subsequently the patient underwent robotic thymectomy. Histologic examination and immunophenotyping of the cervical lymph node in a 12 year old boy revealed neoplastic proliferation of T lymphoblasts diagnostic of T lymphoblastic leukemia/lymphoma. Examination of the anterior mediastinal mass biopsy in the 23 year old woman revealed type B1 thymoma which was confirmed after examination of the subsequent robotic thymectomy specimen.
Conclusion
This is the first reported case of T cell lymphoblastic lymphoma and the third reported case of thymoma associated with sustained hyperthyroidism due to Graves disease. These cases indicate that an anterior mediastinal mass in a patient with active Graves disease may be due to a neoplastic cause, which may require definitive treatment. Caution should be exercised when dismissing a mediastinal mass as benign thymic hyperplasia in patients with active Graves disease.
Graves disease
Hyperthyroidism
Thymoma
T Lymphoblastic leukemia/lymphoma
Thymic hyperplasia
Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia?
Article
oai:TheScholarship.intra.ecu.edu:10342/116882022-11-03T07:16:08Zcom_10342_74com_10342_73col_10342_97
Younes, Ahmed I.
Jackson, Monica
Dal Zotto, Valeria L.
2022-11-02T18:34:14Z
2022-11-02T18:34:14Z
2022
1941-5923
http://hdl.handle.net/10342/11688
10.12659/AJCR.935407
en_US
Angiomyolipoma
Kidney Neoplasms
Oncocytoma, Renal
A Rare Case of Synchronous Oncocytoma and Angiomyolipoma of the Kidney
Article
oai:TheScholarship.intra.ecu.edu:10342/75252021-03-03T21:24:23Zcom_10342_74com_10342_73col_10342_97
Nyce, Jonathan W.
2019-11-05T21:21:39Z
2019-11-05T21:21:39Z
2000-10-26
International Publication # WO2000062736A3
http://hdl.handle.net/10342/7525
An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA comprises the topical admistration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide that is antisense to the initiation codon region, coding region, 5' or 3' inton-exon junctions or regions within 2 to 10 nucleotides of the junctions of the target gene, or antisense to a mRNA complementary to the target gene in an amount effective to reach the target polynucleotide and reducing or inhibiting expression. Additionally, a method of treating and adenosine mediated effect is described also utilizing the delivery of antisense and in order to minimize triggering adenosine receptors by their metabolism, the administered oligos have a low content of or are essentially free of adenosine. The agent, composition and formulations are used for prophlactic, preventive and therapeutic treatment of ailments associated with impaired respiration, lung allergies and/or vasoconstriction, inflammation, allergies, allergic rhynitis, asthma, impeded respiration, lung pain, cystic fibrosis and bronchoconstriction.
en_US
adenosine
asthma
bronchiodilation
Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion
Patent
oai:TheScholarship.intra.ecu.edu:10342/124052023-03-14T07:16:33Zcom_10342_74com_10342_73col_10342_97
Younes, Ahmed I.
Majeed, Marwan M.
Vora, Moiz
Richardson, Maurice D.
2023-03-13T12:59:31Z
2023-03-13T12:59:31Z
2022-11-17
2772-736X
http://hdl.handle.net/10342/12405
10.1016/j.hpr.2022.300682
en_US
Activated B-cell
Lymphoma
Signet-ring
Activated B-Cell Signet Ring Lymphoma: A Case Report and a Comparative Review of the Literature
Article
oai:TheScholarship.intra.ecu.edu:10342/57432021-03-03T21:12:13Zcom_10342_74com_10342_73col_10342_97
Hong, Heng
Patonay, Bryan
Finley, James
2016-06-27T15:24:17Z
2016-06-27T15:24:17Z
2011
Diagnostic Pathology; 6: p. 15-15
1746-1596
http://hdl.handle.net/10342/5743
pmc3049127
10.1186/1746-1596-6-15
Background
Special stains, such as reticulin stain and CD34 immunostain, are very helpful in the diagnosis of well differentiated hepatocellular carcinoma (HCC). Most studies have shown that absent or decreased reticulin stain or an abnormal reticulin pattern with widened trabeculae is reliable for the diagnosis of well-differentiated HCC.
Case report
We report here two cases of well differentiated HCC with an unusual reticulin staining pattern. A strongly positive reticulin network was preserved within the tumor, which surrounded individual tumor cells in a monolayered trabecular pattern. At the same time, an increased CD34 stain was present in the tumor.
Conclusions
This unusual reticulin pattern represents part of the diverse reticulin staining patterns seen in HCC. Although this staining pattern is rare, it should be recognized when diagnosing well-differentiated HCC in small samples such as cellblock of fine needle aspiration or small core biopsies.
Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma
Article