2024-03-28T16:57:39Zhttps://thescholarship.ecu.edu/oai/requestoai:TheScholarship.intra.ecu.edu:10342/96912022-02-10T08:15:04Zcom_10342_74com_10342_73col_10342_98
Projected Estimates of African American Medical Graduates of Closed Historically Black Medical Schools
Tumin, Dmitry
Projected Estimates
African American Medical Graduates
Black Medical Schools
2022-02-10T02:02:50Z
2022-02-10T02:02:50Z
2020-08-03
Article
2574-3805
http://hdl.handle.net/10342/9691
10.1001/jamanetworkopen.2020.15220
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/96872022-02-10T08:15:05Zcom_10342_74com_10342_73col_10342_98
Decrease in heart rate following the administration of sugammadex in adults
Tumin, Dmitry
Sugammadex
heart rate
adults
2022-02-10T02:02:06Z
2022-02-10T02:02:06Z
2020-10
Article
0970-9185
http://hdl.handle.net/10342/9687
10.4103/joacp.JOACP_346_19
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/30672021-03-03T20:57:58Zcom_10342_74com_10342_73col_10342_98
The agony of agonal respiration: is the last gasp necessary?
Perkin, R. M.
Resnik, D. B.
Agonal respiration
Neuromuscular blocker
End of life care
Gasping respiration in the dying patient is the last respiratory pattern prior to terminal apnoea. The
duration of the gasping respiration phase varies; it may be as brief as one or two breaths to a
prolonged period of gasping lasting minutes or even hours. Gasping respiration is very abnormal, easy
to recognise and distinguish from other respiratory patterns and, in the dying patient who has elected
to not be resuscitated, will always result in terminal apnoea.
Gasping respiration is also referred to as agonal respiration and the name is appropriate because the
gasping breaths appear uncomfortable and raise concern that the patient is suffering and in agony.
Enough uncertainty exists about the influence of gasping respiration on patient wellbeing, that it is
appropriate to assume that the gasping breaths are burdensome to patients. Therefore, gasping respiration
at the end of life should be treated.
We propose that there is an ethical basis, in rare circumstances, for the use of neuromuscular blockade
to suppress prolonged episodes of agonal respiration in the well-sedated patient in order to allow a
peaceful and comfortable death. Originally published Journal of Medical Ethics, Vol. 28, No. 3, June 2002
2011-01-21T19:35:07Z
2011-05-17T00:49:06Z
2011-01-21T19:35:07Z
2011-05-17T00:49:06Z
2002-06
Article
Journal of Medical Ethics; 28:3 p. 164-169
http://hdl.handle.net/10342/3067
PMC1733591
10.1136/jme.28.3.164
en_US
http://jme.bmj.com/content/by/year/2002
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/10882021-03-03T20:55:00Zcom_10342_74com_10342_73col_10342_98
Effect of gender on auditory brainstem response latencies and thresholds to air-and bone-conducted clicks in newborn infants
Effect of Gender on ARB Latencies Thresholds
Stuart, Andrew
Yang, Edward Y.
Auditory brainstem response
Latency
Threshold
Gender
Auditory adaptation
Brain stem
Sex differences
Evoked Potentials
Gender identity
Auditory
Brain Stem
Objective: An examination of gender differences in auditory brainstem response (ABR) wave V latencies and thresholds to air-and bone- conducted clicks was undertaken with newborn infants. Design: Two hundred and two full-term newborn infants served as participants (i.e., 103 males and 99 females). Wave V latency measures for air-and bone-conducted click stimuli of 30, 45, and 60 dB nHL and 15 and 30 dB nHL, respectively and thresholds to air-and bone-conducted clicks were determined. Results: Female newborns displayed statistically significant shorter wave V latencies than male newborns for air-conducted click stimuli (p = .0016). There were no significant differences in wave V latencies to bone- conducted click stimuli (p = .11). Females displayed lower ABR thresholds to both air-and bone-conducted stimuli but the differences did not attain statistical significance (p = .054 and p = .18 for air-and bone-conducted stimuli, respectively). Conclusion: The findings of gender disparities in ABR latencies and thresholds to air-conducted clicks may be attributed to either anatomical differences at the periphery or more efficient neural conduction in the auditory nerve and/or brainstem. It was speculated that gender-related Effect of Gender On ABR Latencies and Thresholds 4 differences in bone density or maturation of the skull sutures could affect bone-conducted signal transmission to the cochlea thereby offsetting some inefficiency offered by air-conduction with newborn males. This in turn would minimize gender differences with bone-conducted stimuli.
2008-08-15T15:08:44Z
2009-08-07T13:47:37Z
2011-05-17T00:49:06Z
2008-08-15T15:08:44Z
2009-08-07T13:47:37Z
2011-05-17T00:49:06Z
2001
Article
Journal of Communication Disorders; 34:3 p. 229-239
http://hdl.handle.net/10342/1088
10.1016/S0021-9924(01)00048-X
en
1 p.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/96852022-02-10T08:15:04Zcom_10342_74com_10342_73col_10342_98
Scholarly Productivity of Faculty in Primary Care Roles Related to Tenure Versus Non-Tenure Tracks
Tumin, Dmitry
Scholarly productivity
faculty
tenure versus non-tenure tracks
2022-02-10T02:01:48Z
2022-02-10T02:01:48Z
2020-05-29
Article
1472-6920
http://hdl.handle.net/10342/9685
10.1186/s12909-020-02085-6
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/57542021-03-03T21:12:32Zcom_10342_74com_10342_73col_10342_98
Promising insights into the health related quality of life for children with severe obesity
Selewski, David T.
Collier, David N.
MacHardy, Jackie
Gross, Heather E.
Pickens, Edward M.
Cooper, Alan W.
Bullock, Selam
Earls, Marian F.
Pratt, Keeley J.
Scanlon, Kelli
McNeill, Jonathan D.
Messer, Kassandra L.
Lu, Yee
Thissen, David
DeWalt, Darren A.
Gipson, Debbie S.
Obesity
Patient Reported Outcomes Measurement Information System (PROMIS)
Child
Depression
Quality of life
Background
Childhood obesity is a growing health concern known to adversely affect quality of life in children and adolescents. The Patient Reported Outcomes Measurement Information System (PROMIS) pediatric measures were developed to capture child self-reports across a variety of health conditions experienced by children and adolescents. The purpose of this study is to begin the process of validation of the PROMIS pediatric measures in children and adolescents affected by obesity.
Methods
The pediatric PROMIS instruments were administered to 138 children and adolescents in a cross-sectional study of patient reported outcomes in children aged 8–17 years with age-adjusted body mass index (BMI) greater than the 85th percentile in a design to establish known-group validity. The children completed the depressive symptoms, anxiety, anger, peer relationships, pain interference, fatigue, upper extremity, and mobility PROMIS domains utilizing a computer interface. PROMIS domains and individual items were administered in random order and included a total of 95 items. Patient responses were compared between patients with BMI 85 to < 99th percentile versus ≥ 99th percentile.
Results
136 participants were recruited and had all necessary clinical data for analysis. Of the 136 participants, 5% ended the survey early resulting in missing domain scores at the end of survey administration. In multivariate analysis, patients with BMI ≥ 99th percentile had worse scores for depressive symptoms, anger, fatigue, and mobility (p < 0.05). Parent-reported exercise was associated with better scores for depressive symptoms, anxiety, and fatigue (p < 0.05).
Conclusions
Children and adolescents ranging from overweight to severely obese can complete multiple PROMIS pediatric measures using a computer interface in the outpatient setting. In the 5% with missing domain scores, the missing scores were consistently found in the domains administered last, suggesting the length of the assessment is important. The differences in domain scores found in this study are consistent with previous reports investigating the quality of life in children and adolescents with obesity. We show that the PROMIS instrument represents a feasible and potentially valuable instrument for the future study of the effect of pediatric obesity on quality of life.
2016-06-27T16:12:41Z
2016-06-27T16:12:41Z
2013
Article
Health and Quality of Life Outcomes; 11: p. 29-29
1477-7525
http://hdl.handle.net/10342/5754
pmc3598567
10.1186/1477-7525-11-29
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598567/
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/96892022-02-10T08:15:05Zcom_10342_74com_10342_73col_10342_98
Impact of Intraoperative Fluid Management on Electrolyte and Acid-Base Variables During Posterior Spinal Fusion in Adolescents
Tumin, Dmitry
Intraoperative Fluid Management
Electrolyte and Acid-Base Variables
Posterior Spinal Fusion
2022-02-10T02:02:24Z
2022-02-10T02:02:24Z
2020-07-27
Article
1179-1462
http://hdl.handle.net/10342/9689
0.2147/ORR.S262509
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/123372023-02-16T08:16:24Zcom_10342_74com_10342_73col_10342_98
Local Economic Inequality and the Primary Care Physician Workforce in North Carolina
Tumin, Dmitry
Nenow, Joseph
Nenow, Andrew
Priest, Allison
Campbell, Kendall M.
Economic Inequality
Primary Care Physician Workforce
North Carolina
2023-02-15T16:43:33Z
2023-02-15T16:43:33Z
2022
Article
1557-2625
http://hdl.handle.net/10342/12337
10.3122/jabfm.2022.01.210117
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/34212021-03-03T20:55:16Zcom_10342_74com_10342_73col_10342_98
Prenatal diagnosis of a giant intracranial teratoma associated with pulmonary hypoplasia.
Weyerts, Leah K.
Catanzarite, Val
Jones, Marilyn C.
Mendoza, Arturo
Intracranial tumor
Teratoma
Pulmonary hypoplasia
We present a case in which an intracranial tumour replacing all intracranial contents was diagnosed by sonography at 31 weeks' gestation. The patient was delivered by caesarean section and died shortly after delivery. At necropsy, the tumour was found to be a teratoma with no recognisable normal brain tissue present. Additional findings at necropsy included pulmonary and adrenal hypoplasia. The diagnosis and prognosis of intracranial teratomas diagnosed in utero, and the association of this tumour with pulmonary hypoplasia, are discussed. Originally published Journal of Medical Genetics, Vol. 30, No. 10, Oct 1993
2011-04-28T18:30:22Z
2011-05-17T00:49:05Z
2011-04-28T18:30:22Z
2011-05-17T00:49:05Z
1993-10
Article
Journal of Medical Genetics; 30:10 p. 880-882
http://hdl.handle.net/10342/3421
PMC1016576
en_US
http://jmg.bmj.com/content/by/year/1993
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/96802022-02-10T08:14:54Zcom_10342_74com_10342_73col_10342_98
County Rankings Have Limited Utility When Predicting Liver Transplant Outcomes
Tumin, Dmitry
County Rankings
Predicting
Liver Transplant Outcomes
2022-02-10T02:01:09Z
2022-02-10T02:01:09Z
2020-01
Article
0163-2116
http://hdl.handle.net/10342/9680
10.1007/s10620-019-05734-z
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/57502022-12-14T16:12:48Zcom_10342_74com_10342_73col_10342_98
Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates
Korzeniewski, Steven J.
Allred, Elizabeth N.
Logan, J. Wells
Fichorova, Raina N.
Engelke, Stephen C.
Kuban, Karl C. K.
O'Shea, T. Michael
Paneth, Nigel
Holm, Mari
Dammann, Olaf
Leviton, Alan
Brain damage
Cerebral palsy
Inflammation
Microcephaly
Blood
Infants
Birth weight
Background
We sought to determine, in very preterm infants, whether elevated perinatal erythropoietin (EPO) concentrations are associated with increased risks of indicators of brain damage, and whether this risk differs by the co-occurrence or absence of intermittent or sustained systemic inflammation (ISSI).
Methods
Protein concentrations were measured in blood collected from 786 infants born before the 28th week of gestation. EPO was measured on postnatal day 14, and 25 inflammation-related proteins were measured weekly during the first 2 postnatal weeks. We defined ISSI as a concentration in the top quartile of each of 25 inflammation-related proteins on two separate days a week apart. Hypererythropoietinemia (hyperEPO) was defined as the highest quartile for gestational age on postnatal day 14. Using logistic regression and multinomial logistic regression models, we compared risks of brain damage among neonates with hyperEPO only, ISSI only, and hyperEPO+ISSI, to those who had neither hyperEPO nor ISSI, adjusting for gestational age.
Results
Newborns with hyperEPO, regardless of ISSI, were more than twice as likely as those without to have very low (< 55) Mental (OR 2.3; 95% CI 1.5-3.5) and/or Psychomotor (OR 2.4; 95% CI 1.6-3.7) Development Indices (MDI, PDI), and microcephaly at age two years (OR 2.4; 95%CI 1.5-3.8). Newborns with both hyperEPO and ISSI had significantly increased risks of ventriculomegaly, hemiparetic cerebral palsy, microcephaly, and MDI and PDI < 55 (ORs ranged from 2.2-6.3), but not hypoechoic lesions or other forms of cerebral palsy, relative to newborns with neither hyperEPO nor ISSI.
Conclusion
hyperEPO, regardless of ISSI, is associated with elevated risks of very low MDI and PDI, and microcephaly, but not with any form of cerebral palsy. Children with both hyperEPO and ISSI are at higher risk than others of very low MDI and PDI, ventriculomegaly, hemiparetic cerebral palsy, and microcephaly.
2016-06-27T15:38:56Z
2016-06-27T15:38:56Z
2015-03
Article
PLoS ONE; 10:3 p. 1-18
1932-6203
http://hdl.handle.net/10342/5750
pmc4368546
10.1371/journal.pone.0115083
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115083
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/112882022-09-22T07:16:00Zcom_10342_74com_10342_73col_10342_98
Trajectories of Unsecured Debt and Health at Midlife
Tumin, Dmitry
Frech, Adrianne
Houle, Jason
Debt
Midlife
Pain
2022-09-21T13:54:10Z
2022-09-21T13:54:10Z
2021-06-13
Article
2352-8273
http://hdl.handle.net/10342/11288
10.1016/j.ssmph.2021.100846
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/57512021-03-03T21:12:52Zcom_10342_74com_10342_73col_10342_98
Effects of Secondhand Smoke Exposure on the Health and Development of African American Premature Infants
Brooks, Jada
Holditch-Davis, Diane
Weaver, Mark A.
Miles, Margaret Shandor
Engelke, Stephen C.
Objective. To explore the effects of secondhand smoke exposure on growth, health-related illness, and child development in rural African American premature infants through 24 months corrected age. Method. 171 premature infants (72 boys, 99 girls) of African American mothers with a mean birthweight of 1114 grams. Mothers reported on household smoking and infant health at 2, 6, 12, 18, and 24 months corrected age. Infant growth was measured at 6, 12, 18, and 24 months, and developmental assessments were conducted at 12 and 24 months. Results. Thirty percent of infants were exposed to secondhand smoke within their first 2 years of life. Secondhand smoke exposure was associated with poorer growth of head circumference and the development of otitis media at 2 months corrected age. Height, weight, wheezing, and child development were not related to secondhand smoke exposure. Conclusion. Exposure to secondhand smoke may negatively impact health of rural African American premature infants. Interventions targeted at reducing exposure could potentially improve infant outcomes.
2016-06-27T15:39:51Z
2016-06-27T15:39:51Z
2011
Article
International Journal of Family Medicine; 2011: p. 1-9
2090-2042
http://hdl.handle.net/10342/5751
pmc3263834
10.1155/2011/165687
http://www.hindawi.com/journals/ijfm/2011/165687/
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/57552021-03-03T21:12:34Zcom_10342_74com_10342_73col_10342_98
Quality of life and BMI changes in youth participating in an integrated pediatric obesity treatment program
Pratt, Keeley J.
Lazorick, Suzanne
Lamson, Angela L.
Ivanescu, Andrada
Collier, David N.
Pediatric obesity
Quality of life
Depression
Obesity treatment
Background
Changes in Quality of Life (QOL) measures over time with treatment of obesity have not previously been described for youth. We describe the changes from baseline through two follow up visits in youth QOL (assessed by the Pediatric Quality Life Inventory, PedsQL4.0), teen depression (assessed by the Patient Health Questionnaire, PHQ9A), Body Mass Index (BMI) and BMI z-score. We also report caregiver proxy ratings of youth QOL.
Methods
A sample of 267 pairs of youth and caregiver participants were recruited at their first visit to an outpatient weight-treatment clinic that provides care integrated between a physician, dietician, and mental health provider; of the 267, 113 attended a visit two (V2) follow-up appointment, and 48 attended visit three (V3). We investigated multiple factors longitudinally experienced by youth who are overweight and their caregivers across up to three different integrated care visits. We determined relationships at baseline in QOL, PHQ9A, and BMI z-score, as well as changes in variables over time using linear mixed models with time as a covariate.
Results
Overall across three visits the results indicate that youth had slight declines in relative BMI, significant increases in their QOL and improvements in depression.
Conclusions
We encourage clinicians and researchers to track youth longitudinally throughout treatment to investigate not only youth’s BMI changes, but also psychosocial changes including QOL.
2016-06-27T16:14:23Z
2016-06-27T16:14:23Z
2013
Article
Health and Quality of Life Outcomes; 11: p. 116-116
1477-7525
http://hdl.handle.net/10342/5755
pmc3710490
10.1186/1477-7525-11-116
http://hqlo.biomedcentral.com/articles/10.1186/1477-7525-11-116
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/96882022-02-10T08:15:05Zcom_10342_74com_10342_73col_10342_98
Characteristics of Medical School Applicants: A Single-Institution Study
Tumin, Dmitry
Medical School
characteristics
Single-Institution Study
2022-02-10T02:02:15Z
2022-02-10T02:02:15Z
2020-11
Article
0742-3225
http://hdl.handle.net/10342/9688
10.22454/FamMed.2020.615345
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/108972022-07-21T08:32:53Zcom_10342_74com_10342_73col_10342_98
The Potential Effect of Metabolic Alkalosis on Insulin Sensitivity in an Adolescent with New-Onset Type 1 Diabetes
Novotny, William E.
Fiordalisi, Irma
Keel, Cynthia P.
Harris, Glenn D.
insulin sensitivity
metabolic alkalosis
type 1 diabetes
2022-07-20T14:05:17Z
2022-07-20T14:05:17Z
2021
Article
2050-0904
http://hdl.handle.net/10342/10897
10.1002/ccr3.3915
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/117232022-11-10T08:16:26Zcom_10342_74com_10342_73col_10342_98
The ASK-SEAT: A Competency-Based Assessment Scale for Students Majoring in Clinical Medicine
Zheng, Yingying
Competency-based assessment
Medical education
Licensing examination
2022-11-09T13:34:35Z
2022-11-09T13:34:35Z
2022-02-04
Article
1472-6920
http://hdl.handle.net/10342/11723
10.1186/s12909-022-03140-0
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/114992022-10-13T07:15:58Zcom_10342_74com_10342_73col_10342_98
Six-Year Neurodevelopmental Outcomes for Children With Single-Ventricle Physiology
Milazzo, Angelo
Sananes, Renee
Goldberg, Caren S.
Newburger, Jane W.
Hu, Chenwei
Trachtenberg, Felicia
Gaynor, J. William
Mahle, William T.
Miller, Thomas
Uzark, Karen
Mussatto, Kathleen A.
Pizarro, Christian
Jacobs, Jeffrey P.
Cnota, James
Atz, Andrew M.
Lai, Wyman W.
Burns, Kristin M.
Votava-Smith, Jodie
Brosig, Cheryl L.
Neurodevelopmental Outcomes
Single Ventricle Reconstruction
Children
2022-10-12T17:43:41Z
2022-10-12T17:43:41Z
2021
Article
0031-4005
http://hdl.handle.net/10342/11499
10.1542/peds.2020-014589
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/123382023-02-16T08:16:24Zcom_10342_74com_10342_73col_10342_98
Health Care Usage Among Adolescents With Congenital Heart Defects at 5 Sites in the United States, 2011 to 2013
Sarno, Lauren
Lui, George K.
et al
adolescent
heart defects, congenital
prevalence
2023-02-15T19:13:09Z
2023-02-15T19:13:09Z
2022
Article
2047-9980
http://hdl.handle.net/10342/12338
10.1161/JAHA.122.026172
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/33682021-03-03T20:55:08Zcom_10342_74com_10342_73col_10342_98
Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease
Offenbacher, Steven
Beck, James D.
Moss, Kevin
Mendoza, Luisito
Paquette, David W.
Barrow, David A.
Couper, David J.
Steward, Dawn D.
Falkner, Karen L.
Graham, Susan P.
Grossi, Sara
Gunsolley, John C.
Madden, Theresa
Maupome, Gerardo
Trevisan, Maurizio
Van Dyke, Thomas E.
Genco, Robert J.
C-reactive protein
Cardiovascular Diseases
Controlled clinical trials
Obesity
Periodontitis
Prevention
Background- In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. Methods- Subjects were randomized to either community care or protocol provided scaling and root planing to evaluate effects on periodontal status and systemic levels of high-sensitivity Creactive protein (hs-CRP). Results- After 6 months, there was a significant reduction in mean probing depth and extent of 4- or 5-mm pockets. However, there were no significant differences in attachment levels, bleeding upon probing, or extent of subgingival calculus comparing subjects assigned to protocol therapy (n = 151) to those assigned to community care (n = 152). Using intent-to-treat analyses, there was no significant effect on serum hs-CRP levels at 6 months. However, 48% of the subjects randomized to community care received preventive or periodontal treatments. Secondary analyses demonstrated that consideration of any preventive or periodontal care (i.e., any treatment) compared to no treatment showed a significant reduction in the percentage of people with elevated hs-CRP (values >3 mg/l)at 6 months. However, obesity nullified the periodontal treatment effects on hs-CRP reduction. The adjusted odds ratio for hs-CRP levels >3 mg/l at 6 months for any treatment versus no treatment among non-obese individuals was 0.26 (95%confidence interval: 0.09 to 0.72), adjusting for smoking, marital status, and gender. Conclusion- This pilot study demonstrated the critical role of considering obesity as well as rigorous preventive and periodontal care in trials designed to reduce cardiovascular risk. Originally published Journal of Periodontology, Vol. 80, No. 2, Feb 2009
2011-04-15T19:26:50Z
2011-05-17T00:49:05Z
2011-04-15T19:26:50Z
2011-05-17T00:49:05Z
2009-02
Article
Journal of Periodontology; 80:2 p. 190-201
http://hdl.handle.net/10342/3368
PMC2778200
en_US
http://www.joponline.org/doi/abs/10.1902/jop.2009.080007%20?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/123292023-02-15T08:16:29Zcom_10342_74com_10342_73col_10342_98
Energy- and Protein-Enriched Formula Improves Weight Gain in Infants with Malnutrition Due to Cardiac and Noncardiac Etiologies
Sang, Charlie J. Jr.
Goday, Praveen S.
et al
cardiac disease
enteral nutrition
pediatrics
2023-02-14T16:22:02Z
2023-02-14T16:22:02Z
2022
Article
0148-6071
http://hdl.handle.net/10342/12329
10.1002/jpen.2308
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/110762022-09-10T07:16:01Zcom_10342_74com_10342_73col_10342_98
Impact of COVID-19 on Pediatric Primary Care Visits at Four Academic Institutions in the Carolinas
Simeonsson, Kristina
Townsend, John D.
Brown, Callie L.
Montez, Kimberly
Amati, Jane Blakely
Orr, Colin J.
Palakshappa, Deepak
COVID-19
pediatrics
primary care
2022-09-09T13:05:54Z
2022-09-09T13:05:54Z
2021-05-27
Article
1660-4601
http://hdl.handle.net/10342/11076
10.3390/ijerph18115734
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/29962021-03-03T20:54:53Zcom_10342_74com_10342_73col_10342_98
Traces of embryogenesis are the same in monozygotic and dizygotic twins: not compatible with double ovulation
Boklage, Charles E.
Twins
Dizygotic
Chimeras
Double ovulation
Monozygotic
Common knowledge of over a century has it that monozygotic and dizygotic twinning events occur by unrelated mechanisms: monozygotic twinning ‘splits’ embryos, producing anomalously re-arranged embryogenic asymmetries; dizygotic twinning begins with independent ovulations yielding undisturbed parallel embryogeneses with no expectation of departures from singleton outcomes. The anomalies statistically associated with twin births are due to the re-arranged embryos of the monozygotics. Common knowledge further requires that dizygotic pairs are dichorionic; monochorionicity is exclusive to monozygotic pairs. These are fundamental certainties in the literature of twin biology. Multiple observations contradict those common knowledge understandings. The double ovulation hypothesis of dizygotic twinning is untenable. Girl–boy twins differ subtly from all other humans of either sex, absolutely not representative of all dizygotics. Embryogenesis of dizygotic twins differs from singleton development at least as much as monozygotic embryogenesis does, and in the same ways, and the differences between singletons and twins of both zygosities represent a coherent system of re-arranged embryogenic asymmetries. Dizygotic twinning and monozygotic twinning have the same list of consequences of anomalous embryogenesis. Those include an unignorable fraction of dizygotic pairs that are in fact monochorionic, plus many more sharing co-twins’ cells in tissues other than a common chorion. The idea that monozygotic and dizygotic twinning events arise from the same embryogenic mechanism is the only plausible hypothesis that might explain all of the observations. Originally published in Human Reproduction, Vol. 24, No. 6, 2009.
2010-11-08T19:13:19Z
2011-05-17T00:49:06Z
2010-11-08T19:13:19Z
2011-05-17T00:49:06Z
2009-06
Article
Human Reproduction; 24:6 p. 1255-1266
http://hdl.handle.net/10342/2996
PMC2683734
en_US
http://humrep.oxfordjournals.org/content/24/6.toc
Permission granted by author to Kent Nixon Myers to upload this article on 09/27/2010.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/57532021-03-03T21:12:26Zcom_10342_74com_10342_73col_10342_98
Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study
Gipson, Debbie S.
Selewski, David T.
Massengill, Susan F.
Wickman, Larysa
Messer, Kassandra L.
Herreshoff, Emily
Bowers, Corinna
Ferris, Maria E.
Mahan, John D.
Greenbaum, Larry A.
MacHardy, Jackie
Kapur, Gaurav
Chand, Deepa H.
Goebel, Jens
Barletta, Gina Marie
Geary, Denis
Kershaw, David B.
Pan, Cynthia G.
Gbadegesin, Rasheed
Hidalgo, Guillermo
Lane, Jerome C.
Leiser, Jeffrey D.
Plattner, Brett W.
Song, Peter X.
Thissen, David
Liu, Yang
Gross, Heather E.
DeWalt, Darren A.
Patient reported outcomes
Quality of life
Nephrotic syndrome
Pediatrics
Background and objectives
Nephrotic syndrome (NS) represents a common disease in pediatric nephrology typified by a relapsing and remitting course and characterized by the presence of edema that can significantly affect the health-related quality of life in children and adolescents. The PROMIS pediatric measures were constructed to be publically available, efficient, precise, and valid across a variety of diseases to assess patient reports of symptoms and quality of life. This study was designed to evaluate the ability of children and adolescents with NS to complete the PROMIS assessment via computer and to initiate validity assessments of the short forms and full item banks in pediatric NS. Successful measurement of patient reported outcomes will contribute to our understanding of the impact of NS on children and adolescents.
Design
This cross-sectional study included 151 children and adolescents 8-17 years old with NS from 16 participating institutions in North America. The children completed the PROMIS pediatric depression, anxiety, social-peer relationships, pain interference, fatigue, mobility and upper extremity functioning measures using a web-based interface. Responses were compared between patients experiencing active NS (n = 53) defined by the presence of edema and patients with inactive NS (n = 96) defined by the absence of edema.
Results
All 151 children and adolescents were successfully able to complete the PROMIS assessment via computer. As hypothesized, the children and adolescents with active NS were significantly different on 4 self-reported measures (anxiety, pain interference, fatigue, and mobility). Depression, peer relationships, and upper extremity functioning were not different between children with active vs. inactive NS. Multivariate analysis showed that the PROMIS instruments remained sensitive to NS disease activity after adjusting for demographic characteristics.
Conclusions
Children and adolescents with NS were able to successfully complete the PROMIS instrument using a web-based interface. The computer based pediatric PROMIS measurement effectively discriminated between children and adolescents with active and inactive NS. The domain scores found in this study are consistent with previous reports investigating the health-related quality of life in children and adolescents with NS. This study establishes known-group validity and feasibility for PROMIS pediatric measures in children and adolescents with NS.
2016-06-27T16:10:37Z
2016-06-27T16:10:37Z
2013
Article
Health and Quality of Life Outcomes; 11: p. 30-30
1477-7525
http://hdl.handle.net/10342/5753
pmc3599189
10.1186/1477-7525-11-30
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599189/
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/34122021-03-03T20:55:11Zcom_10342_74com_10342_73col_10342_98
Off-label Utilization of Antihypertensive Medications in Children
Yoon, Esther Y.
Dombkowski, Kevin J.
Rocchini, Albert
Lin, Jen-Jar
Davis, Matthew M.
Antihypertensive drugs
Children
Food and Drug Administration
Hypertension
Off label
Objective— To examine off-label utilization and costs of antihypertensive drugs in children using a national sample of prescription claims. Design— Cross-sectional study. Setting— 2002 Medstat MarketScan Database, a national sample of outpatient prescription claims of children ≥18 years old enrolled in private, employer-sponsored health plans. Main Outcome Measures— Off-label use of antihypertensive drugs by patient age and costs of
antihypertensives calculated as mean cost per child per 30-day fill.
Results— One-half of the index antihypertensive prescription claims were off-label, based on minimum age criteria. Boys were more likely (56%) than girls (46%) to be prescribed off-label antihypertensives (p<0.001). Children aged ≥12 years were more likely to be prescribed off-label antihypertensives (53%) compared with children aged ≥5 (46%) and 6–11 years (42%, p<0.001). Off-label use varied significantly by class of antihypertensive drugs (p<0.001). Overall, off-label antihypertensives were significantly more expensive than on-label antihypertensives. Conclusions— Despite availability of often less expensive on-label alternatives for the same class of antihypertensive drugs, off-label antihypertensive drugs were prescribed frequently in children. These findings underscore the potential clinical and economic implications of common off-label prescribing, for children, their parents, physicians and payers. Originally published Ambulatory Pediatrics, Vol. 7, No. 4, July 2007
2011-04-28T18:09:36Z
2011-05-17T00:49:05Z
2011-04-28T18:09:36Z
2011-05-17T00:49:05Z
2007-07
Article
Ambulatory Pediatrics; 7:4 p. 299-303
http://hdl.handle.net/10342/3412
PMC2144799
10.1016/j.ambp.2007.04.005
en_US
http://www.ambulatorypediatrics.org/article/S1530-1567(07)00080-9/abstract
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/30012022-12-14T17:25:07Zcom_10342_74com_10342_73col_10342_98
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
Fuh, Beng
Sobo, M.
Cen, L.
Josiah, D.
Hutzen, B.
Cisek, K.
Bhasin, D.
Regan, N.
Lin, L.
Chan, C.
Caldas, H.
DeAngelis, S.
Li, C.
Li, P-K.
Lin, J.
STAT3
Apoptosis
Glioblastoma
LLL-3
Persistent activation of the signal transducer and activator of transcription 3 (STAT3) signalling has been linked to oncogenesis and the development of chemotherapy resistance in glioblastoma and other cancers. Inhibition of the STAT3 pathway thus represents an attractive therapeutic approach for cancer. In this study, we investigated the inhibitory effects of a small molecule compound known as LLL-3, which is a structural analogue of the earlier reported STAT3 inhibitor, STA-21, on the cell viability of human glioblastoma cells, U87, U373, and U251 expressing constitutively activated STAT3. We also investigated the inhibitory effects of LLL-3 on U87 glioblastoma cell growth in a mouse tumour model as well as the impact it had on the survival time of the treated mice. We observed that LLL-3 inhibited STAT3-dependent transcriptional and DNA binding activities. LLL-3 also inhibited viability of U87, U373, and U251 glioblastoma cells as well as induced apoptosis of these glioblastoma cell lines as evidenced by increased poly (ADP-ribose) polymerase (PARP) and caspase-3 cleavages. Furthermore, the U87 glioblastoma tumour-bearing mice treated with LLL-3 exhibited prolonged survival relative to vehicle-treated mice (28.5 vs 16 days) and had smaller intracranial tumours and no evidence of contralateral invasion. These results suggest that LLL-3 may be a potential therapeutic agent in the treatment of glioblastoma with constitutive STAT3 activation. Originally published in British Journal of Cancer 2009 Vol. 110, No. 1
2010-11-10T15:55:24Z
2011-05-17T00:49:04Z
2010-11-10T15:55:24Z
2011-05-17T00:49:04Z
2009-01-13
Article
British Journal of Cancer; 100:1 p. 106-112
http://hdl.handle.net/10342/3001
PMC2634692
10.1038/sj.bjc.6604793
en_US
http://www.nature.com/bjc/journal/v100/n1/full/6604793a.html
Author notified of opt-out rights by Kent Nixon Myers prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/33512021-03-03T20:54:45Zcom_10342_74com_10342_73col_10342_98
Association of pneumothorax and hypotension with intraventricular haemorrhage
Mehrabani, Dariush
Gowen, C. W. Jr.
Kopelman, Arthur E.
Pneumothorax
Very low birth weight
Intraventricular haemorrhage
To test the hypothesis that acute hyotension resulting from pneumothorax would be associated with severe brain injury (grade 3 or 4 intraventricular haemorrhage), 67 very low birthweight (VLBW) infants of 32 weeks' gestation or less with respiratory distress syndrom and pneumothorax were studies. Thirty six had pneumothorax associated with systemic hypotension and 31 had pneumothorax with normal blood pressure. The groups were similar in gestational age and severity of their respiratory distress syndrome. Thirty two of 36 of infants with pneumothorax associated with hypotension (89%) had grade 3 or 4 intraventricular haemorrhage. This percentage was significantly greater than the percentage for infants with pneumothorax and normal blood pressure (three of 31, 10%). The risk ratio for grade 3 or 4 intraventricular haemorrhage for infants with pneumothorax associated with hypotension was 9-8 compared with neonates with pneumothorax and normal blood pressure. These observations are consistent with the hypothesis that systemic hypotension and cerebral hypoperfusion are important factors leading to intraventricular haemorrhage in VLBW infants. Originally published Archives of Disease in Childhood, Vol. 66, No. 1, Jan 1991
2011-04-15T19:02:16Z
2011-05-17T00:49:07Z
2011-04-15T19:02:16Z
2011-05-17T00:49:07Z
1991-01
Article
Archives of Disease in Childhood; 66:1 Spec No. p. 48-51
http://hdl.handle.net/10342/3351
PMC1590345
10.1136/adc.66.1_Spec_No.48
en_US
http://adc.bmj.com/
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/123932023-03-03T08:16:29Zcom_10342_74com_10342_73col_10342_98
Children’s Unmet Need for Mental Health Care Within and Outside Metropolitan Areas
Pasli, Melisa
Tumin, Dmitry
adolescent
mental health
rural health services
2023-03-02T18:45:35Z
2023-03-02T18:45:35Z
2022-06-22
Article
1875-9572
http://hdl.handle.net/10342/12393
10.1016/j.pedneo.2022.03.018
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/123462023-02-21T08:16:16Zcom_10342_74com_10342_73col_10342_98
Social Determinants of Emergency Department Visits in Mild Compared To Moderate and Severe Asthma
Alachraf, Kamel
Currie, Caroline
Wooten, William
Tumin, Dmitry
Social determinants
emergency department
asthma
2023-02-20T14:11:29Z
2023-02-20T14:11:29Z
2022-03-23
Article
0341-2040
http://hdl.handle.net/10342/12346
10.1007/s00408-022-00524-3
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/115722022-10-22T07:19:01Zcom_10342_74com_10342_73col_10342_98
Impact of Body Mass Index, Socioeconomic Status, and Bedtime Technology Use on Sleep Duration in Adolescents
Stine, Frederick
Collier, David N.
Fang, Xiangming
Dew, Kelsey Ross
Lazorick, Suzanne
sleep
adolescents
obesity
2022-10-21T12:24:20Z
2022-10-21T12:24:20Z
2021
Article
0009-9228
http://hdl.handle.net/10342/11572
10.1177/00099228211047791
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/30642021-03-03T20:55:14Zcom_10342_74com_10342_73col_10342_98
Response to Kuhse
Perkin, R. M.
Resnik, D. B.
Neuromuscular blocking drugs
End of life care
Moral distinctions
In this short paper, we respond to critics of our original paper, The agony of agonal respiration: is the
last gasp necessary?. A common thread in both Hawryluckâ s and Kuhseâ s responses is the difficulties
encountered when using the agentâ s intentions to make moral distinctions between using neuromuscular
blocking drugs to palliate versus using neuromuscular blocking drugs to kill. Although this difficulty does
exist we maintain that the intentions of the physician must matter when providing end-of-life care. Originally published Journal of Medical Ethics, Vol. 28, No. 4, Aug. 2002
2011-01-21T19:25:46Z
2011-05-17T00:49:06Z
2011-01-21T19:25:46Z
2011-05-17T00:49:06Z
2002-08
Article
Journal of Medical Ethics; 28:4 p. 273-274
http://hdl.handle.net/10342/3064
PMC1733602
en_US
http://jme.bmj.com/content/by/year/2002
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/121652023-02-03T08:22:47Zcom_10342_74com_10342_73col_10342_98
Influence of Measles-Mumps-Rubella Vaccine Series Initiation and Completion on Influenza Vaccination Among Adolescents
Cortright, Lindsay
Buckman, Cierra
Tumin, Dmitry
Syed, Salma
Beeninga, F. Trent
Childhood vaccines
MMR
Vaccine hesitancy
2023-02-02T18:49:02Z
2023-02-02T18:49:02Z
2022-03
Article
2352-6467
http://hdl.handle.net/10342/12165
10.1016/j.ijpam.2020.12.001
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/96922022-02-10T08:15:05Zcom_10342_74com_10342_73col_10342_98
Comparison of the Skin-to-Epidural Space Distance at the Thoracic and Lumbar Levels in Children Using Magnetic Resonance Imaging
Tumin, Dmitry
skin‑to‑epidural space
thoracic and lumbar levels
magnetic resonance imaging
2022-02-10T02:02:59Z
2022-02-10T02:02:59Z
2020
Article
1658-354X
http://hdl.handle.net/10342/9692
10.4103/sja.SJA_292_20
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/116522022-10-25T08:35:37Zcom_10342_74com_10342_73col_10342_98
Sharing the Power of White Privilege to Catalyze Positive Change in Academic Medicine
Tumin, Dmitry
RodrÃguez, José E.
Campbell, Kendall M.
Academic medicine
Equity
White privilege
2022-10-24T18:17:55Z
2022-10-24T18:17:55Z
2021
Article
2196-8837
http://hdl.handle.net/10342/11652
10.1007/s40615-020-00947-9
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/124522023-04-03T13:57:04Zcom_10342_74com_10342_73col_10342_98
Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice
Boutlier, Susan B.
et al
genetic etiologies
Epilepsy Treatment
Clinical Practice
2023-04-03T13:57:04Z
2023-04-03T13:57:04Z
2022-10-31
Article
2168-6149
http://hdl.handle.net/10342/12452
10.1001/jamaneurol.2022.3651
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/116922022-11-04T07:16:08Zcom_10342_74com_10342_73col_10342_98
Preparing Faculty to Incorporate Health Systems Science into the Clinical Learning Environment: Factors Associated with Sustained Outcomes
Lazorick, Suzanne
Lawson, Luan
Higginson, Jason
Garris, Jenna
Baxley, Elizabeth G.
Teherani, Arianne
Dekhtyar, Michael
health systems science
quality improvement
medical education
2022-11-03T14:30:17Z
2022-11-03T14:30:17Z
2022
Article
1062-8606
http://hdl.handle.net/10342/11692
10.1097/JMQ.0000000000000028
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/57522021-03-03T21:12:54Zcom_10342_74com_10342_73col_10342_98
Effects of a Behavior-Based Weight Management Program Delivered Through a State Cooperative Extension and Local Public Health Department Network, North Carolina, 2008-2009
MacKenzie Whetstone, Lauren
Kolasa, Kathryn M.
Dunn, Carolyn Kusbit
Jayaratne, K. S. U.
Aggarwal, Surabhi
Vodicka, Sherée
Schneider, Lori
Thomas, Cathy
van Staveren, Meg
Lackey, Carolyn
Introduction
Eat Smart, Move More, Weigh Less (ESMMWL) is an adult weight management program developed in response to North Carolina Obesity Plan recommendations to make weight management interventions accessible to underserved populations. ESMMWL was designed to be delivered through the North Carolina Cooperative Extension and North Carolina Division of Public Health. Program coursework included content on evidence-based eating and physical activity behaviors and incorporated mindful eating concepts. The objectives of this study were to describe participant changes in weight and behaviors and to document the effectiveness of the program.
Methods
In this prospective pilot study, courses were delivered and data collected from January 2008 through June 2009. Instructors provided feedback about implementation. For participants, height, weight, and waist circumference were measured at baseline and completion. Participants completed a questionnaire about changes in their eating and physical activity behaviors, changes in their confidence to engage in weight management behaviors, and their satisfaction with the course.
Results
Seventy-nine instructors delivered 101 ESMMWL courses in 48 North Carolina counties. Most of the 1,162 completers were white women. Approximately 83% reported moving toward or attaining their goal. The average weight loss was 8.4 lb. Approximately 92% reported an increase in confidence to eat healthfully, and 82% reported an increase in confidence to be physically active. Instructors made suggestions for program standardization.
Conclusion
This study demonstrated the effectiveness, diffusion, and implementation of a theoretically based weight management program through a state extension and local public health department network. Study of the sustainability of changes in eating and physical activity behaviors is needed.
2016-06-27T15:41:01Z
2016-06-27T15:41:01Z
2011-07
Article
Preventing Chronic Disease; 8:4 p. 1-9
1545-1151
http://hdl.handle.net/10342/5752
pmc3136981
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136981/
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/123162023-02-11T08:17:36Zcom_10342_74com_10342_73col_10342_98
Development of the PREMature Infant Index (PREMIITM), a Clinician-Reported Outcome Measure Assessing Functional Status of Extremely Preterm Infants
Higginson, Jason
Ward, Robert M.
Clinician-reported outcome measure
extremely premature
functional status
2023-02-10T20:11:14Z
2023-02-10T20:11:14Z
2022
Article
1476-4954
http://hdl.handle.net/10342/12316
10.1080/14767058.2020.1735338
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/33782022-03-14T12:20:30Zcom_10342_74com_10342_73col_10342_98
Bolstering Confidence in Obesity Prevention and Treatment Counseling for Resident and Community Pediatricians
Perrin, Eliana M.
Jacobson Vann, Julie C.
Lazorick, Suzanne
Ammerman, Alice S.
Teplin, Sari
Wegner, Steven E.
Benjamin, John T.
Childhood overweight
Counseling
Residency
Nutrition
Physical activity
Objective- To assess whether equipping resident pediatricians and community pediatricians with both training and practical tools improves their perceived confidence, ease, and frequency of obesity related counseling to patients.
Methods- In 2005-2006, resident pediatricians (n = 49) and community pediatricians (n=18) received training regarding three evidence-based obesity prevention/treatment tools and responded to pre-and post-intervention questionnaires. We analyzed changes in reported mean confidence, ease, and frequency of dietary, physical activity, and weight status counseling.
Results- Baseline scores of confidence, ease, and frequency of counseling were higher in community pediatricians than residents. Mean scores increased significantly in the combined group, among residents only, and trended towards improvement in the community pediatricians following the intervention. Means for "control" questions were unchanged.
Conclusion- Training and tools for residents and community pediatricians improved their confidence, ease, and frequency of obesity-related counseling.
Practice Implications- This study demonstrates that when feasible and appropriate tools and training were provided through a simple intervention, physicians gained confidence and ease and increased their counseling frequency. The results here suggest that widespread implementation of such educational interventions for community practitioners and practitioners in training could change the way physicians counsel patients to prevent the often frustrating problem of childhood obesity. Originally published Patient Education and Counseling, Vol. 73, No. 2, Nov 2008
2011-04-28T14:41:50Z
2011-05-17T00:49:07Z
2011-04-28T14:41:50Z
2011-05-17T00:49:07Z
2008-11
Article
Patient Education and Counseling; 73:2 p. 179-185
http://hdl.handle.net/10342/3378
PMC2700835
10.1016/j.pec.2008.07.025
en_US
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBC-4T9JWCR-2&_user=634873&_coverDate=11%2F30%2F2008&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=52a35874022f050f7e89da44cba68fcd&searchtype=a
Author notified of opt-out rights by Cammie Jennings prior to upload of this article.
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/32442021-03-03T20:55:12Zcom_10342_74com_10342_73col_10342_98
Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?
Burke, Leah W.
Wiley, John E.
Glenn, Christopher C.
Driscoll, Daniel J.
Loud, Kenneth M.
Smith, April J. W.
Kushnick, Theodore
Angelman syndrome
Cryptic translocation
AS gene location
Angelman syndrome (AS) is associated with a loss of maternal genetic information, which typically occurs as a result of a deletion at 15ql1-q13 or paternal uniparental disomy of chromosome 15. We report a patient with AS as a result of an unbalanced cryptic translocation whose breakpoint, at 15q11.2, falls within this region. The proband was diagnosed clinically as having Angelman syndrome, but without a detectable cytogenetic deletion, by using high-resolution G-banding. FISH detected a deletion of D15S11 (IR4-3R), with an intact GABRB3 locus. Subsequent studies of the proband's mother and sister detected a cryptic reciprocal translocation between chromosomes 14 and 15 with the breakpoint being between SNRPN and D15S1O (3-21). The proband was found to have inherited an unbalanced form, being monosomic from 15pter through SNRPN and trisomic for 14pter to 14q11.2. DNA methylation studies showed that the proband had a paternal-only DNA methylation pattern at SNRPN, D15S63 (PW71), and ZNF127. The mother and unaffected sister, both having the balanced translocation, demonstrated normal DNA methylation patterns at all three loci. These data suggest that the gene for AS most likely lies proximal to D15S1O, in contrast to the previously published position, although a less likely possibility is that the maternally inherited imprinting center acts in trans in the unaffected balanced translocation carrier sister. Originally published American Journal of Human Genetics, Vol. 58, No. 4, Apr 1996
2011-02-17T16:00:18Z
2011-05-17T00:49:06Z
2011-02-17T16:00:18Z
2011-05-17T00:49:06Z
1996-04
Article
American Journal of Human Genetics; 58:4 p. 777-784
http://hdl.handle.net/10342/3244
PMC1914665
en_US
http://www.cell.com/AJHG/archive
Author notified of opt-out rights by Cammie Jennings
application/pdf
East Carolina University
oai:TheScholarship.intra.ecu.edu:10342/95732022-02-01T08:15:41Zcom_10342_7351com_10342_6421com_10342_74com_10342_73col_10342_9479col_10342_98
Impact of BMI, Socioeconomic Status and Bedtime Technology Use on Sleep Duration in Adolescents
Stine, Frederick
Collier, David N.
Fang, Xiangming
Dew, Kelsey Ross
Lazorick, Suzanne
sleep
adolescents
obesity
technology use
Factors related to adolescents and sleep are understudied. We evaluate the relationship between bedtime technology use (TU), TV in bedroom, weight, and socioeconomic status in seventh graders (N = 3956) enrolled in a school-based wellness intervention. Sleep quantity was dichotomized to insufficient (<8 hours) or sufficient (?8 hours); high TU before sleep was defined by use “a few nights each week� or “every, or almost every night.� Insufficient sleep (38.7%), having TV in bedroom (72.9%), and high TU (83.1%) were commonly reported. The likelihood of sufficient sleep was lower for those with high TU (odds ratio [OR] = 0.529 [0.463-0.605]), obese students (OR = 0.815 [0.700-0.949]), and those with a TV in the bedroom (OR = 0.817 [0.703-0.950]). Also, attending a school with higher percent low socioeconomic status students was also associated with insufficient sleep (P = .026). Interventions to reduce TU may be important for improving sleep quantity, especially for some vulnerable populations.
ECU Open Access Publishing Support Fund
2022-01-31T16:24:39Z
2022-01-31T16:24:39Z
2021-09-25
Article
http://hdl.handle.net/10342/9573
10.1177/00099228211047791
https://doi.org/10.1177%2F00099228211047791
application/pdf
Sage
oai:TheScholarship.intra.ecu.edu:10342/96832022-02-10T08:15:04Zcom_10342_74com_10342_73col_10342_98
The Role of North Carolina Medical Schools in Producing Primary Care Physicians for the State
Tumin, Dmitry
access to care
underserved communities
primary care
2022-02-10T02:01:32Z
2022-02-10T02:01:32Z
2020-01
Article
2150-1319
http://hdl.handle.net/10342/9683
10.1177/2150132720924263
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/117142022-12-09T19:36:10Zcom_10342_74com_10342_73col_10342_98
Obesity II: Establishing Causal Links Between Chemical Exposures and Obesity
Collier, David N.
Obesogen
Adipocyte differentiation
Obesity
2022-11-08T16:12:22Z
2022-11-08T16:12:22Z
2022-04-05
Article
0006-2952
http://hdl.handle.net/10342/11714
10.1016/j.bcp.2022.115015
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/118232022-12-08T08:17:00Zcom_10342_74com_10342_73col_10342_98
Factors Influencing US Hospital and Medical School Participation in Pediatric COVID-19 Research
Tumin, Dmitry
Sasser, Georgia
Buckman, Cierra
Khanchandani, Ashish
Pediatric COVID-19 Research
US Hospitals Participation
Medical School Participation
2022-12-07T14:56:24Z
2022-12-07T14:56:24Z
2022
Article
2154-1671
http://hdl.handle.net/10342/11823
10.1542/HPEDS.2021-006051
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/96822022-02-10T08:15:04Zcom_10342_74com_10342_73col_10342_98
Heart Rate Changes Following the Administration of Sugammadex to Infants and Children With Comorbid Cardiac, Cardiovascular, and Congenital Heart Diseases
Tumin, Dmitry
Heart Rate Changes
Sugammadex
Infants and Children
2022-02-10T02:01:24Z
2022-02-10T02:01:24Z
2020-10
Article
1923-2829
http://hdl.handle.net/10342/9682
14740/cr1045
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/118292022-12-09T08:16:49Zcom_10342_74com_10342_73col_10342_98
De Novo Pediatric Ulcerative Colitis Triggered by SARS-CoV-2 Infection: a Tale of 2 Sisters
Preziosi, Nicholas A.
Rizvi, Areeba H.
Feerick, John D.
Mandelia, Chetan
Ulcerative Colitis
SARS-CoV-2 Infection
infammatory bowel disease (IBD)
2022-12-08T16:18:00Z
2022-12-08T16:18:00Z
2022-06-28
Article
1078-0998
http://hdl.handle.net/10342/11829
10.1093/ibd/izac142
en_US
application/pdf
oai:TheScholarship.intra.ecu.edu:10342/47902021-03-03T20:56:30Zcom_10342_1com_10342_74com_10342_73col_10342_72col_10342_98
Sugar-Sweetened Beverage Consumption and Food Insecurity in Pediatric Patients with Obesity
Bostick, Kimberly Paige
Collier, David N.
Brody School of Medicine
Obesity
Sugar-sweetened beverages
Pediatrics
Food insecurity
Consumption of sugar sweetened beverages and food insecurity are both thought to contribute to the development of obesity. However, little is known about the quantity and quality of sugar-sweetened beverages consumed, the prevalence of food insecurity, or if these are related, in treatment-seeking patients. A retrospective chart review of obese children and adolescents seeking treatment at ECU's Healthy Weight Clinic was conducted. A validated beverage consumption instrument was employed to assess total calories contributed by beverages, with a focus on those, which are considered sugar-sweetened beverages. Food insecurity was assessed with the USDA short form with two validated questions. Sugar-sweetened beverages are a significant source of excess calories in obese children. Food insecurity appears to be a risk factor for high sugar-sweetened beverage consumption and suggests that financial concerns may be linked to poor nutritional literacy. This study was done in order to find if in fact food insecurity within family units leads to increased consumption of sugar-sweetened beverages. Our hypothesis was that there would be a strong correlation between perceived food insecurity and a high caloric intake from sugar-sweetened beverages. Each patient was given the two validated food insecurity questions from the USDA short form and there were answers of Never True, Sometimes True, or Often True for both questions. Answers of Sometimes True or Often True were deemed as perceived food insecurity. The beverage survey data along with the food insecurity answers were analyzed using the Statistical Package for the Social Sciences (SPSS) software and the results between gender, ethnicity, age, income-based assistance, beverage calories, and food insecurities were compared. Our results show that on average, children in families with perceived food insecurities consumed an excess of one hundred calories from the average sugar-sweetened beverage consumption calories of the cohort.
B.A.
2015-05-05T14:54:37Z
2015-05-05T14:54:37Z
2015-04-30
Honors Thesis
Bostick, Kimberly P. 2015. Sugar-Sweetened Beverage Consumption and Food Insecurity in Pediatric Patients with Obesity. Unpublished Manuscript, Honors College, East Carolina University, Greenville, N.C.
http://hdl.handle.net/10342/4790
en_US
application/vnd.openxmlformats-officedocument.wordprocessingml.document
oai:TheScholarship.intra.ecu.edu:10342/57492021-03-03T21:00:00Zcom_10342_74com_10342_73col_10342_98
Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis
Hoffman, William H.
Passmore, Gregory G.
Hannon, David W.
Talor, Monica V.
Fox, Pam
Brailer, Catherine
Haislip, Dynita
Keel, Cynthia
Harris, Glenn
Rose, Noel R.
Fiordalisi, Irma
Čiháková, Daniela
Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6–12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA.
2016-06-27T15:36:41Z
2016-06-27T15:36:41Z
2013
Article
PLoS ONE; 8:8 p. 1-13
1932-6203
http://hdl.handle.net/10342/5749
pmc3754936
10.1371/journal.pone.0071905
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071905
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oai:TheScholarship.intra.ecu.edu:10342/33022021-03-03T20:54:57Zcom_10342_74com_10342_73col_10342_98
Patterns of Distress in African American Mothers of Preterm Infants
Holditch-Davis, Diane
Miles, Margaret Shandor
Weaver, Mark A.
Black, Beth
Beeber, Linda
Thoyre, Suzanne
Engelke, Stephen C.
Maternal psychological distress
Prematurity
Depression
Anxiety
Stress
Objective: To examine inter-relationships among stress due to infant appearance and behavior in the NICU, parental role alteration stress in the NICU, depressive symptoms, state anxiety, posttraumatic stress symptoms, and daily hassles exhibited by African American mothers of preterm infants and to determine whether there were sub-groups of mothers based on patterns of psychological distress. Method: 177 African American mothers completed questionnaires on their psychological distress at enrollment during infant hospitalization and 2, 6, 12, 18, and 24 months after term. Results: Psychological distress measures were inter-correlated. There were four latent classes of mothers: the low distress class with low scores on all measures; the high NICU-related stress class with high infant appearance and parental role stress and moderate scores on other measures; the high depressive symptoms class with high depressive symptoms and state anxiety and moderately elevated scores on NICU-related stress and post-traumatic stress symptoms; the extreme distress class with the highest means on all measures. Infants in the high stress class were sicker than infants in the other classes. The extreme distress class mothers averaged the lowest educational level. The classes differed on distress measures, worry about the child, and parenting stress through 24 months with the extreme distress class having the highest values. Conclusion: Although different types of maternal psychological distress were substantially related, there were distinct sub-groups of mothers that were identifiable in the NICU. Moreover, these sub-groups continued to differ on trajectories of distress and on their perceptions of the infants and parenting through 24 months after term. Originally published Journal of Developmental and Behavioral Pediatrics, Vol. 30, No. 3, June 2009
2011-03-02T20:07:06Z
2011-05-17T00:49:07Z
2011-03-02T20:07:06Z
2011-05-17T00:49:07Z
2009-06
Article
Journal of Developmental and Behavioral Pediatrics; 30:3 p. 193-205
http://hdl.handle.net/10342/3302
PMC2755596
en_US
http://ovidsp.tx.ovid.com/sp-3.3.1a/ovidweb.cgi?QS2=434f4e1a73d37e8c01e9bb09ab15b39201d3938fc4fac764a087c5187de36f45448c2193a2f98ea8c2ae9b27a5bd6230b115b9ef916083edda9a510ce4f9c16d2e5496e302e395990eeba55beaa9e529520d8a256d67d6707e7c3c09ca3704bfcc2d56c2192e986ada7497942f85c661a009d77ebb6b2e1af88ecdb9f255bf6f279191e563c8648e4a31fdb478174d21a1d0190f80e1647266f40214b4581eb06a1ebd8aa9ed91eeae8d1b6277a78758d6679b82d4d4bcaf3feb23032894b8b3803f61ef08d005495dcf2dbb62e6fa1ec3ef6f331e5c14acc8f204496c59fe19505d2f71252ba501f38920e7ee989dc3
Author notified of opt-out rights by Cammie Jennings.
application/pdf
East Carolina University