Browsing by Author "Abrams, Stephen L."

Now showing items 21-27 of 27

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health 

    Chappell, William H.; Steelman, Linda S.; Long, Jacquelyn M.; Kempf, Ruth C.; Abrams, Stephen L.; Franklin, Richard A.; Bäsecke, Jörg; Stivala, Franca; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Mazzarino, Maria C.; Nicoletti, Ferdinando; Libra, Massimo; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Montalto, Giuseppe; Cervello, Melchiorre; Laidler, Piotr; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Evangelisti, Camilla; Cocco, Lucio; Martelli, Alberto M.; McCubrey, James A. (2011-03-11)
    The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...

  • Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells 

    McCubrey, James A.; Fitzgerald, Timothy L.; Yang, Li V.; Lertpiriyapong, Kvin; Steelman, Linda S.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Neri, Luca M.; Cocco, Lucio; Martelli, Alberto M.; Laidler, Piotr; Dulińska-Litewka, Joanna; Rakus, Dariusz; Gizak, Agnieszka; Nicoletti, Ferdinando; Falzone, Luca; Candido, Saverio; Libra, Massimo (2017-02)
    Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...

  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging 

    Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Kempf, C. Ruth; Long, Jacquelyn M.; Laidler, Piotr; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Stivala, Franca; Mazzarino, Maria C.; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Nicoletti, Ferdinando; Libra, Massimo; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Bäsecke, Jörg; Cocco, Lucio; Evangelisti, Camilla; Martelli, Alberto M.; Montalto, Giuseppe; Cervello, Melchiorre; McCubrey, James A. (2011-03)
    Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ...

  • Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance 

    McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Wong, Ellis W.T.; Chang, Fumin; Lehmann, Brian D.; Terrian, David M.; Milella, Michele; Tafuri, Agostino; Stivala, Franca; Libra, Massimo; Basecke, Jorg; Evangelisti, Camilla; Martelli, Alberto M.; Franklin, Richard A. (East Carolina University, 2007-08)
    Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ...

  • Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells 

    Abrams, Stephen L.; Ruvolo, Peter P.; Ruvolo, Vivian R.; Ligresti, Giovanni; Martelli, Alberto M.; Cocco, Lucio; Ratti, Stefano; Tafuri, Agostino; Steelman, Linda S.; Candido, Saverio; Libra, Massimo; McCubrey, James A. (2017-08-24)
    A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ...

  • Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance 

    McCubrey, James A.; Steelman, Linda S.; Franklin, Richard A.; Abrams, Stephen L.; Chappell, William H.; Wong, Ellis W.T.; Lehmann, Brian D.; Terrian, David M.; Basecke, Jorg; Stivala, Franca; Libra, Massimo; Evangelisti, Camilla; Martelli, Alberto M. (East Carolina University, 2007)

  • Wild Type and Gain of Function Mutant TP53 can Regulate the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutic Drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 Pathway Inhibitors, Nutraceuticals and Alter Metabolic Properties 

    McCubrey, James A.; Meher, Akshaya K.; Akula, Shaw M.; Abrams, Stephen L.; Steelman, Linda S.; LaHair, Michelle M.; Franklin, Richard A.; Martelli, Alberto M.; Ratti, Stefano; Cocco, Lucio; Barbaro, Fulvio; Duda, Przemysław; Gizak, Agnieszka (2022-04-27)