Browsing by Subject "cancer"

Now showing items 21-25 of 25

  • Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer 

    Candido, Saverio; Maestro, Roberta; Polesel, Jerry; Catania, Alessia; Maira, Francesca; Signorelli, Santo S.; McCubrey, James A.; Libra, Massimo (2014-03)
    Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ...

  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging 

    Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Kempf, C. Ruth; Long, Jacquelyn M.; Laidler, Piotr; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Stivala, Franca; Mazzarino, Maria C.; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Nicoletti, Ferdinando; Libra, Massimo; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Bäsecke, Jörg; Cocco, Lucio; Evangelisti, Camilla; Martelli, Alberto M.; Montalto, Giuseppe; Cervello, Melchiorre; McCubrey, James A. (2011-03)
    Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ...

  • A Soft Spot 

    Snyder, Rebecca A. (2022-03-17)

  • The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers 

    Justus, Calvin Richard (East Carolina University, 2017-03-16)
    In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ...

  • Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells 

    Kim, Do Hyung (East Carolina University, 2016-05-03)
    Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...