Browsing by Subject "Molecular biology"
Now showing items 21-40 of 65
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Effects of Exogenous and Autocrine Growth Hormone (hGH) on Prostate Cancer Cell Function
(East Carolina University, 2012)Human growth hormone (hGH) is a major product of the anterior pituitary. In addition to its endocrine activities, hGH overexpression in extra-pituitary tissues has been correlated with the oncogenic behavior of these ... -
The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29.
(East Carolina University, 2013)Hox genes are a subgroup of the large family of homeobox containing genes, known to pattern anterior/posterior and proximal/distal axes during embryonic development. More recently Hox gene research has focused on the role ... -
ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM
(East Carolina University, 2012)Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS, a hetero-tetrameric protein complex is known to be essential for the initiation and progression of ... -
EXPLORING THE BYSTANDER EFFECT FOLLOWING VERY LOW DOSE RADIATION
(East Carolina University, 2010)Bystander effects are defined as the phenomenon in which unirradiated cells respond biologically when their neighbors are irradiated. The exact mechanisms of these cellular responses are still not known, especially in ... -
Fesselin, an intrinsically disordered smooth muscle protein, organizes and stabilizes actin-myosin and myosin
(East Carolina University, 2014)Fesselin is an intrinsically disordered protein that is known to bind a large variety of cytoskeletal proteins. The proteins fesselin is known to bind include: actin (Leinweber et al. 1999), [alpha]-actinin (Pham et al. ... -
A Functional Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2012)MicroRNAs (miRNAs) are a newly discovered class of endogenous post-transcriptional gene regulators that are typically 20-22 nucleotides in length that do not code for proteins. MiRNAs regulate gene expression by either ... -
A Genetic Screen for Mcm10: Interactions Between Mcm10 and Deficiency Regions on the Third Chromosome of Drosophila Melanogaster
(2015)Mis-regulation of the Mcm10 gene has been linked with multiple forms of cancer, including many forms of breast cancer (Thu, Y. 2014). Despite this, the role of Mcm10 in cancer is not yet fully known. One way to study a ... -
Genome-Wide Identification And Expression Analysis Of TCP Transcription Factors In Cotton
(East Carolina University, 2015)TCP proteins are plant-specific transcription factors known to perform a variety of physiological functions during plant growth and development. In the current study, we performed for the first time the comprehensive ... -
Hox Gene Expression During Oreochromis niloticus Pharyngeal Arch Development : Discovering the Hox Code
(East Carolina University, 2010)Hox genes encode transcription factors and have been extensively studied by evolutionary and developmental biologists. Hox genes are responsible for determining specific regional identities along the anterior-posterior and ... -
Human T-cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) Interacts and Inhibits the Acetyltransferase Activity of Multiple Cellular Coactivator Families to Deregulate Transcription
(East Carolina University, 1/13/16)Of the 20 million individuals infected worldwide with the complex retrovirus, Human T-cell Leukemia Virus Type 1, 5% will develop an incurable and fatal form of leukemia known as adult T-cell leukemia (ATL). During the ... -
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2010)microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ... -
An Information-Theoretic Approach to Cellular Decision-Making Strategies: How Rate Distortion Theory Provides an Optimal Method for Describing Binary Cellular Decision-Making Systems
(2014)Rate distortion theory, a branch of information theory, was originally developed to help improve the efficiency of data transmission in telecommunications. It's currently being used as a major modeling method to provide ... -
Interaction and Functional Analysis of Drosophila Mcm10
(East Carolina University, 2010)In eukaryotic cells, DNA replication and the subsequent packaging of DNA into specific chromatin states are essential processes for the transmission of genetic material and genomic stability which may be linked by interactions ... -
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ... -
LOCALIZATION AND CHANGES OF NUCLEAR PROGESTERONE RECEPTORS IN ZEBRAFISH OOCYTES AND ADJACENT FOLLICULAR CELLS
(East Carolina University, 2010)The nuclear progesterone receptor (Pgr) is one of the major mediators for progestin signaling during oocyte ovulation in vertebrates. However, any roles Pgr may play in oocyte growth, and especially in the final oocyte ... -
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
(East Carolina University, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ... -
Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ...