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AGE-DEPENDENT STUDY OF PATHOLOGICAL PROGRESSION OF ALZHEIMER’S DISEASE IN HIPPOCAMPAL AND CORTICAL TISSUE OF HUMAN AND AN AD MOUSE MODEL
(East Carolina University, 2019-05-02)Degeneration of synaptic plasticity plays a critical role in Alzheimer’s disease (AD) pathogenesis. Recent studies have suggested that neuroinflammation may contribute to this degeneration by disrupting the amyloid metabolism ... -
Age-Related Diagnostic Considerations and Neurocognitive Impairment Implications for Insomnia Disorder
(East Carolina University, 2023-12-01)Insomnia affects 10-30% of the U.S. population and can be found across varying stages of life. While it has previously been shown that the addition of quantitative indices would be helpful for distinguishing between sleep ... -
Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
(2000-10-24)An agent of the chemical formula C.sub.7 N.sub.3 H.sub.8 O.sub.2 R.sup.1 R.sup.2 XX.sup.1, wherein X and X.sup.1 are each independently C or N but not simultaneously, R.sup.1 is lower alkyl, alkenyl or alkynyl, halogen or ... -
Ages and Stages Questionnaire: a global screening scale | Ages and Stages Questionnaire: una escala de evaluación global
(2017-01-30)Abstract With standardized screening tools, research studies have shown that developmental disabilities can be detected reliably and with validity in children as young as 4 months of age by using the instruments such as ... -
AGGRESSION, INCIVILITY, FORGIVENESS, AND DEVIANT BEHAVIOR
(East Carolina University, 2014)The purpose of this study was to investigate the incremental validity of forgiveness and experiences of incivility to the prediction of deviant behavior by trait aggression. Participants consisted of 480 undergraduate ... -
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
(East Carolina University, 2000-09-12)Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting ... -
The agony of agonal respiration: is the last gasp necessary?
(East Carolina University, 2002-06)Gasping respiration in the dying patient is the last respiratory pattern prior to terminal apnoea. The duration of the gasping respiration phase varies; it may be as brief as one or two breaths to a prolonged period of ... -
AgRP neuron activity is required for acute exercise-induced feeding
(East Carolina University, 2019-08-13)While much is known about the role of neuropeptide Y/agouti-regulated peptide (NPY/AgRP) and pro-opiomelanocortin (POMC) neurons to regulate energy homeostasis, little is known about how forced energy expenditure, such as ... -
AIM for success with IM
(East Carolina University, 2006)Instant messaging (IM) is a hot topic among libraries today. The past few years have seen a burst of articles in the professional literature describing the technology and the ways in which libraries can incorporate it into ... -
Airway observations during upper endoscopy predicting obstructive sleep apnea
(2016-06-10)Background This pilot study examined airway characteristics during upper endoscopy to determine who is at high risk for obstructive sleep apnea. Methods Patients undergoing routine upper endoscopy were divided into 2 ... -
Akhenaten’s Amarna in New Kingdom Egypt: Relations of Landscape and Ideology
(2016-08)a few years after Pharaoh amenophis iV (ruled ca.1353– 1337 in the Eighteenth dynasty during new Kingdom Egypt) had assumed the highest office in Thebes, he decided to radically reorganize and redirect the Egyptian political ... -
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
(2013-08-24)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ... -
The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy
(2013-09)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ...