Browsing by Author "Cabot, Myles C."
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target
Tan, Su-Fern; Liu, Xin; Fox, Todd E.; Barth, Brian M.; Sharma, Arati; Turner, Stephen D.; Awwad, Andy; Dewey, Alden; Doi, Kenichiro; Spitzer, Barbara; Shah, Mithun Vinod; Morad, Samy A.F.; Desai, Dhimant; Amin, Shantu; Zhu, Junjia; Liao, Jason; Yun, Jong; Kester, Mark; Claxton, David F.; Wang, Hong-Gang; Cabot, Myles C.; Schuchman, Edward H.; Levine, Ross L.; Feith, David J.; Loughran, Thomas P. Jr. (2016-12-13)There is an urgent unmet need for new therapeutics in acute myeloid leukemia (AML) as standard therapy has not changed in the past three decades and outcome remains poor for most patients. Sphingolipid dysregulation through ... -
Alterations in Sphingolipid Composition and Mitochondrial Bioenergetics Represent Synergistic Therapeutic Vulnerabilities Linked to Multidrug Resistance in Leukemia
Fisher-Wellman, Kelsey H.; Hagen, James T.; Nelson, Margaret A. M.; McLaughlin, Kelsey L.; Coalson, Hannah S.; Kassai, Miki; Kao, Li-Pin; Cabot, Myles C. (2022-01) -
Ceramide Nanoliposomes Augment the Efficacy of Venetoclax and Cytarabine in Models of Acute Myeloid Leukemia
Cabot, Myles C.; Khokhlatchev, Andrei V. (2022) -
TARGETING ENZYMES OF SPHINGOLIPID METABOLISM IN TREATMENT OF COLORECTAL CANCER
Pumphrey, Conor Miller (East Carolina University, 2019-05-03)Alterations in sphingolipid (SL) metabolism can contribute to cancer progression as well as chemotherapy resistance. Thus, the enzymes of SL metabolism are exploitable targets for the development of novel therapeutics. ...