Browsing by Author "Funai, Katsuhiko"

Now showing items 1-5 of 5

  • Alternative splicing of UCP1 by non-cell-autonomous action of PEMT 

    Johnson, Jordan M.; Verkerke, Anthony R.P.; Maschek, J. Alan; Ferrara, Patrick J.; Lin, Chien-Te; Kew, Kimberly A.; Neufer, P. Darrell; Lodhi, Irfan J.; Cox, James E.; Funai, Katsuhiko (2019-11-08)
    Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ...

  • Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle 

    Ferrara, Patrick J. (East Carolina University, 2015-12-15)
    Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ...

  • Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice 

    Oh, Jisu; Riek, Amy E.; Darwech, Isra; Funai, Katsuhiko; Shao, JianSu; Chin, Kathleen; Sierra, Oscar L.; Carmeliet, Geert; Ostlund, Richard E.; Bernal-Mizarchi, Carlos (2015)
    Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) ...

  • Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation 

    McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01)

  • Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity 

    Heden, Timothy D.; Johnson, Jordan M.; Ferrara, Patrick J.; Eshima, Hiroaki; Verkerke, Anthony R. P.; Wentzler, Edward J.; Siripoksup, Piyarat; Narowski, Tara M.; Coleman, Chanel B.; Lin, Chien-Te; Ryan, Terence E.; Reidy, Paul T.; Castro Brás, Lisandra E. de; Karner, Courtney M.; Burant, Charles F.; Maschek, J. Alan; Cox, James E.; Mashek, Douglas G.; Kardon, Gabrielle; Boudina, Sihem; Zeczycki, Tonya N.; Rutter, Jared; Shaikh, Saame Raza; Vance, Jean E.; Drummond, Micah J.; Neufer, P. Darrell; Funai, Katsuhiko (2019-09-11)
    Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands induced by contractile activity. ...