Browsing by Author "Galanis, Evanthia"
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Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells
Opyrchal, Mateusz; Salisbury, Jeffrey L.; Zhang, Shuya; McCubrey, James A.; Hawse, John; Goetz, Matthew P.; Lomberk, Gwen A.; Haddad, Tufia; Degnim, Amy; Lange, Carol A.; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2014)Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the ... -
Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
Leontovich, Alexey A.; Salisbury, Jeffrey L.; Veroux, Massimiliano; Tallarita, Tiziano; Billadeau, Daniel; McCubrey, James A.; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2013-05)Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) ... -
Inhibition of Cdk2 kinase activity selectively targets the CD44/CD24 stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
Opyrchal, Mateusz; Salisbury, Jeffrey L.; Iankov, Ianko; Goetz, Matthew P.; McCubrey, James A.; Gambino, Mario W.; Malatino, Lorenzo; Puccia, Giuseppe; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2014-09)Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors ... -
Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells
Opyrchal, Mateusz; Gil, Malgorzata; Salisbury, Jeffrey L.; Goetz, Mathew P.; Suman, Vera; Degnim, Amy; McCubrey, James; Haddad, Tufia; Iankov, Ianko; Kurokawa, Chenye B.; Shumacher, Nicole; Ingle, James N.; Galanis, Evanthia; D’Assoro, Antonino B. (2017-09-01)Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast ... -
NOTCH3 Expression Is Linked to Breast Cancer Seeding and Distant Metastasis
Leontovich, Alexey A.; Jalalirad, Mohammad; Salisbury, Jeffrey L.; Mills, Lisa; Haddox, Candace; Schroeder, Mark; Tuma, Ann; Guicciardi, Maria E.; Zammataro, Luca; Gambino, Mario W.; Amato, Angela; Di Leonardo, Aldo; McCubrey, James; Lange, Carol A.; Liu, Minetta; Haddad, Tufia; Goetz, Matthew; Boughey, Judy C.; Sarkaria, Jann; Wang, Liewei; Ingle, James N.; Galanis, Evanthia; D’Assoro, Antonino B. (2018-09-04)Background: Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. ...