Browsing by Author "Huizar, Isham"
-
Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation
Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane (2013-12)Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ... -
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012)Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP ... -
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
Malur, Anagha; Kavuru, Mani S; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012-06-14)Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher; Barna, Barbara P.; Thomassen, Mary Jane (2013-01-23)Background Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary Jane (2016-07)Background: Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in bronchoalveolar ... -
Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary J. (2016-07-26)Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ...