Browsing by Author "Iankov, Ianko"
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Inhibition of Cdk2 kinase activity selectively targets the CD44/CD24 stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
Opyrchal, Mateusz; Salisbury, Jeffrey L.; Iankov, Ianko; Goetz, Matthew P.; McCubrey, James A.; Gambino, Mario W.; Malatino, Lorenzo; Puccia, Giuseppe; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2014-09)Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors ... -
Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells
Opyrchal, Mateusz; Gil, Malgorzata; Salisbury, Jeffrey L.; Goetz, Mathew P.; Suman, Vera; Degnim, Amy; McCubrey, James; Haddad, Tufia; Iankov, Ianko; Kurokawa, Chenye B.; Shumacher, Nicole; Ingle, James N.; Galanis, Evanthia; D’Assoro, Antonino B. (2017-09-01)Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast ...