Browsing by Author "Interdisciplinary Biological Sciences"
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Changes in zebra finch central nervous system morphology associated with developmental cannabinoid exposure
Gilbert, Marcoita Terreen (East Carolina University, 2012)Adolescent CNS development is a highly organized, coordinated process that is both genetically and environmentally influenced, and is characterized by a period of dynamic, activity-dependent changes in synaptic connectivity. ... -
Evaluating The Essential Functions Of The Replication Factor Mcm10 In Drosophila Melanogaster
Reubens, Michael C. (East Carolina University, 2015)Often referred to as miraculous, life as we know depends not upon miracles but on a series of highly orchestrated and regulated biochemical processes collectively known as the cell cycle. It is through these series of ... -
THE EVOLUTION OFHOX [sic] PARALOG GROUP 2 GENE EXPRESSION AND REGULATION IN THE JAPANESE MEDAKA
Davis, Adam (East Carolina University, 2011)Hox paralog group 2 (PG2) genes are evolutionarily conserved developmental regulatory genes that function to specify rhombomere (r) and pharyngeal arch (PA) identities in animal embryos. Several rounds of whole genome ... -
HIGHER-LEVEL SYSTEMATICS OF THE MILLIPEDES (ARTHROPODA: MYRIAPODA: DIPLOPODA) EVALUATED USING TRANSCRIPTOMIC DATA, MITOCHONDRIAL GENOMICS, AND CLASSIFICATION ANALYSES
Brewer, Michael S. (East Carolina University, 2012)Knowledge of deep level phylogenetic relationships within and between many animal groups is currently lacking. Past attempts to reconstruct these ancient evolutionary relationships once relied chiefly on morphological ... -
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
Cook, Pamela Renee (East Carolina University, 2010)The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ... -
The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response
Rehm, Kristina Elizabeth (East Carolina University, 2010)Poxviruses are large double-stranded DNA viruses with a broad host range and worldwide distribution. The most infamous poxvirus is Variola virus, the causative agent of smallpox, which caused over 500 million deaths in ... -
Recruitment of Estuarine-Dependent Alosines to Roanoke River and Albemarle Sound, North Carolina
Riley, Kenneth Lee Pickrell (East Carolina University, 2012)The deleterious effects of dams on alosine populations are widely documented in many rivers along the Atlantic coast. Alterations to the natural hydrologic regime can disrupt spawning, egg dispersal, and recruitment of ... -
The role of peroxisome proliferator-activated receptor-gamma in surfactant catabolism in the alveolar macrophage
Baker, Anna DeLane (East Carolina University, 2009)Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by surfactant accumulation in the alveolar spaces and alveolar macrophages. Although PAP is rare, surfactant abnormalities occur in many lung diseases ... -
The serine protease from the venom of polistes dominulus contains allergenic epitopes
Fitch, Christina D. (East Carolina University, 2010)The protection introduced by immunotherapy to patients with allergies to paper wasps may be partial depending on the sensitizing species. Partial cross-reactivity between major paper wasp groups may be the reason for ... -
Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
Russell, Amanda Laura (East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ...