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    • Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins 

      Sideridou, Maria; Zakopoulou, Roubini; Evangelou, Konstantinos; Liontos, Michalis; Kotsinas, Athanassios; Rampakakis, Emmanouil; Gagos, Sarantis; Kahata, Kaoru; Grabusic, Kristina; Gkouskou, Kalliopi; Trougakos, Ioannis P.; Kolettas, Evangelos; Georgakilas, Alexandros G.; Volarevic, Sinisa; Eliopoulos, Aristides G.; Zannis-Hadjopoulos, Maria; Moustakas, Aristidis; Gorgoulis, Vassilis G. (2011-12)
      E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent ...