Browsing by Author "Pan, Xiaoping"
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Characterizing Multigenerational Effects of Nicotine-Dependent Behaviors in Caenorhabditis Elegans
Sepic, Lucille Rose (East Carolina University, 2017-05-03)This project aims to investigate the effects nicotine, a highly addictive chemical associated with tobacco smoking, have on offspring (F1 and F2) using the model organism Caenorhabditis elegans (C. elegans). C. elegans is ... -
Comparison of ZnO nanoparticles and ZnCl₂ induced germ cell apoptosis in Caenorhabditis elegans
O'Donnell, Brittany (East Carolina University, 2014)There is inadequate research data available on manufactured ZnO nanoparticles. Manufactured nanoparticles are widely used in various products and production of manufactured nanoparticles is becoming increasingly abundant. ... -
Differential Responses of Wheat (Triticum aestivum L.) and Cotton (Gossypium hirsutum L.) to Nitrogen Deficiency in the Root Morpho-Physiological Characteristics and Potential MicroRNA-Mediated Mechanisms
Oo, Sando; Patterson, Caitlin; Pan, Xiaoping; Zhang, Baohong (2022-06-30) -
Drug-Dependent Behaviors and Nicotinic Acetylcholine Receptor Expressions in Caenorhabditis elegans Following Chronic Nicotine Exposure
Lee, Myon Hee; Polli, Joseph R.; Dobbins, Dorothy L.; Kobet, Robert A.; Farwell, Mary A.; Zhang, Baohong; Pan, Xiaoping (2015-03-01) -
Effects of Nicotine on Caenorhabditis elegans survival, reproduction, and gene expressions : Development of an Invertebrate Animal Model for Drugs of Abuse
Smith, Michael A. (East Carolina University, 2011)Although much is known about the addictive effects of nicotine, the molecular mechanisms of nicotine-induced effects remain largely unclear. Specifically, little is known about the effects of nicotine on gene expression, ... -
EFFECTS OF SODIUM BENOZATE ON FAT DEPOSITION AND GROWTH IN CAENORHABDITIS ELEGANS
Lewis, Leia (East Carolina University, 2019-07-11)Clinical observation has proposed the linkage between the occurrence of obesity and slow weight loss with daily exposure to common food additives such as sodium benzoate. However, well-controlled laboratory experiments on ... -
Effects of Zinc Oxide Nanoparticles on the Pharyngeal Pumping and Neurological Behavior of C. elegans
Lish, Luke R. (East Carolina University, 2018-08-02)Cogent data regarding the effects of manufactured zinc oxide nanoparticles (ZnO-NPs) on human health and other organisms is limited. With the prominence of manufactured ZnO - NPs increasing rapidly in recent years, the ... -
Environmental Development of the External Genitalia
Maurizio, Ciro (East Carolina University, 2018-07-24)Hypospadias is one of the most common birth defects in the world. The incidence of hypospadias has nearly doubled over the past 50 years and now occurs on average in 1 in 125 male newborns each year. Hypospadias is a ... -
Impacts of environmentally relevant levels of the perfluorooctanoic acid (PFOA) replacement compound GenX (Hexafluoropropylene Oxide Dimer Acid) on feeding behavior, mitochondrial ROS, and gene expression in Caenorhabditis elegans
Cash, Storm (East Carolina University, 2023-08-03)Per- and polyfluoroalkyl substances (PFAS) are commercially manufactured chemicals known for widespread usage in different industries. Past research indicating negative health impacts and bioaccumulation in humans and the ... -
Investigating the Effects of Sodium Benzoate on Fat Deposition and Pharyngeal Pumping and Related Genetic Mechanism in Caenorhabditis elegans
Vang, Jerry Xai (East Carolina University, 2022-07-18)Sodium benzoate is a widely used food preservative common in many household products due to its antibacterial and antifungal activities. However, many of its side effects other than as a preservative has been under research ... -
Investigating the role microRNAs play in the root-knot nematode Meloidogyne incognita’s viability, reproduction, and parasitism in cotton
Shepherd, Jennings (East Carolina University, 2023-04-25)Functions of four microRNAs (miRNAs), min-miR1, min-miR71, min-miR100a, and min-miR-124, were investigated in the parasitic nematode Meloidogyne incognita’s (M. incognita’s) overall behavior and mortality. M. incognita is ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
Kobet, Robert A.; Pan, Xiaoping; Zhang, Baohong; Pak, Stephen C.; Asch, Adam S.; Lee, Myon-Hee (2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ... -
Neurological Effects Of A Single Low Level Blast Overpressure Exposure : Behavior And Micro RNA Mechanisms Of Mild Traumatic Brain Injury In A Rodent Model
Dobbins, Dorothy L. (East Carolina University, 2015)The increased use of explosive devices within warfare and acts of terrorism has allowed blast overpressure exposure (BOE) to become a significant concern. The most common wound sustained by BOE is blast-induced mild traumatic ... -
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
Kobet, Robert A. (2015-05)Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ... -
Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs
Taki, Faten A.; Pan, Xiaoping; Lee, Myon-Hee; Zhang, Baohong (2014-12-17)Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular ... -
Nicotine exposure caused significant transgenerational heritable behavioral changes in Caenorhabditis elegans
Taki, Faten A; Pan, Xiaoping; Zhang, Baohong (2013-09)Passive and active exposure to tobacco smoking among youth is directly associated with immediate as well as long-term health deterioration. Despite all public health policies and efforts, the percentage of teenage smokers ... -
Potassium deficiency had a significant effect on the growth, development and microRNA-mediated mechanism in wheat (Triticum aestivum L.)
Thornburg, Thomas (East Carolina University, 2020-11-19)Potassium is a crucial nutrient in the growth and development of plants and lack of available potassium was found to have significant affects in altering the morphology and gene expression of wheat. Wheat plants were grown ... -
RDX and miRNA Expression: Zhang and Pan Respond
Zhang, Baohong; Pan, Xiaoping (East Carolina University, 2009-03) -
RDX Induces Aberrant Expression of MicroRNAs in Mouse Brain and Liver
Zhang, Baohong; Pan, Xiaoping (East Carolina University, 2009-02)Background: Although microRNAs (miRNAs) have been found to play an important role in many biological and metabolic processes, their functions in animal response to environmental toxicant exposure are largely unknown. ... -
Reproductive Toxicity of Crude oil-Dispersant Mixture in Caenorhabditis elegans
Zhang, Yanqiong (East Carolina University, 2016-05-05)As crude oil remains a vital natural resource for the energy need of the world, environmental crude oil spills continue to be a health risk to human beings and ecological systems. During clean-up efforts, surfactant-like ...